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Index > Protein center > ATP2A1(Gene name) > Rabbit
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  • ATP2A1 (Gene name),
  • Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Protein name ),  AT2A1_RABIT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATP2A1;
    Protein name:
    Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(SERCA1;SR Ca(2+)-ATPase 1);
    Alternative:
    Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform;Calcium pump 1;Endoplasmic reticulum class 1/2 Ca(2+) ATPase;
    Organism:
    Rabbit (Oryctolagus cuniculus). 
    General Annotation
    Sub Unit:
    Associated with sarcolipin (SLN) (By similarity) and phospholamban (PLN).
    Function:
    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Sarcoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1001
    Sequence:
    50:
    MEAAHSKSTE | ECLAYFGVSE | TTGLTPDQVK | RHLEKYGHNE | LPAEEGKSLW | 
    100:
    ELVIEQFEDL | LVRILLLAAC | ISFVLAWFEE | GEETITAFVE | PFVILLILIA | 
    150:
    NAIVGVWQER | NAENAIEALK | EYEPEMGKVY | RADRKSVQRI | KARDIVPGDI | 
    200:
    VEVAVGDKVP | ADIRILSIKS | TTLRVDQSIL | TGESVSVIKH | TEPVPDPRAV | 
    250:
    NQDKKNMLFS | GTNIAAGKAL | GIVATTGVST | EIGKIRDQMA | ATEQDKTPLQ | 
    300:
    QKLDEFGEQL | SKVISLICVA | VWLINIGHFN | DPVHGGSWIR | GAIYYFKIAV | 
    350:
    ALAVAAIPEG | LPAVITTCLA | LGTRRMAKKN | AIVRSLPSVE | TLGCTSVICS | 
    400:
    DKTGTLTTNQ | MSVCKMFIID | KVDGDFCSLN | EFSITGSTYA | PEGEVLKNDK | 
    450:
    PIRSGQFDGL | VELATICALC | NDSSLDFNET | KGVYEKVGEA | TETALTTLVE | 
    500:
    KMNVFNTEVR | NLSKVERANA | CNSVIRQLMK | KEFTLEFSRD | RKSMSVYCSP | 
    550:
    AKSSRAAVGN | KMFVKGAPEG | VIDRCNYVRV | GTTRVPMTGP | VKEKILSVIK | 
    600:
    EWGTGRDTLR | CLALATRDTP | PKREEMVLDD | SSRFMEYETD | LTFVGVVGML | 
    650:
    DPPRKEVMGS | IQLCRDAGIR | VIMITGDNKG | TAIAICRRIG | IFGENEEVAD | 
    700:
    RAYTGREFDD | LPLAEQREAC | RRACCFARVE | PSHKSKIVEY | LQSYDEITAM | 
    750:
    TGDGVNDAPA | LKKAEIGIAM | GSGTAVAKTA | SEMVLADDNF | STIVAAVEEG | 
    800:
    RAIYNNMKQF | IRYLISSNVG | EVVCIFLTAA | LGLPEALIPV | QLLWVNLVTD | 
    850:
    GLPATALGFN | PPDLDIMDRP | PRSPKEPLIS | GWLFFRYMAI | GGYVGAATVG | 
    900:
    AAAWWFMYAE | DGPGVTYHQL | THFMQCTEDH | PHFEGLDCEI | FEAPEPMTMA | 
    950:
    LSVLVTIEMC | NALNSLSENQ | SLMRMPPWVN | IWLLGSICLS | MSLHFLILYV | 
    1000:
    DPLPMIFKLK | ALDLTQWLMV | LKISLPVIGL | DEILKFIARN | YLEDPEDERR | 
    1001:
    K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
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    ELISA Kit for Rabbit SERCA1
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    CLIA Kit for Rabbit SERCA1
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    CLIA Kit for Rabbit SERCA1
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    CLIA Kit for Rabbit SERCA1
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    U15014h
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    CLIA Kit for Rabbit SERCA1
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    Polyclonal Antibody for Rabbit SERCA1
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    P15014Rb-m
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    Polyclonal Antibody for Rabbit SERCA1
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    Polyclonal Antibody for Rabbit SERCA1
    Polyclonal Antibody for Rabbit SERCA1
    Polyclonal Antibody for Rabbit SERCA1
    Polyclonal Antibody for Rabbit SERCA1
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    Packing:
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    Monoclonal Antibody for Rabbit SERCA1
    Monoclonal Antibody for Rabbit SERCA1
    Monoclonal Antibody for Rabbit SERCA1
    Monoclonal Antibody for Rabbit SERCA1
    Monoclonal Antibody for Rabbit SERCA1
    Monoclonal Antibody for Rabbit SERCA1
    Protein for Rabbit SERCA1
    Protein for Rabbit SERCA1
    Protein for Rabbit SERCA1
    Protein for Rabbit SERCA1
    Protein for Rabbit SERCA1
    Protein for Rabbit SERCA1

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    References
    1. 1.
      "Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequences."
      Brandl C.J. , Green N.M. , Korczak B. , McLennan D.H.
      Cell44:597-607(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SERCA1B)
    2. 2.
      "Involvement of an arginyl residue in the nucleotide-binding site of Ca(2+)-ATPase from sarcoplasmic reticulum as seen by reaction with phenylglyoxal."
      Corbalan-Garcia S. , Teruel J.A. , Gomez-Fernandez J.C.
      Biochem. J.318:179-185(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 134-140 AND 490-495
    3. 3.
      "Localization of E1-E2 conformational transitions of sarcoplasmic reticulum Ca-ATPase by tryptic cleavage and hydrophobic labeling."
      Andersen J.P. , Vilsen B. , Collins J.H. , Jorgensen P.L.
      J. Membr. Biol.93:85-92(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 199-212; 335-348 AND 506-519
    4. 4.
      "Chemical modification of the Ca(2+)-ATPase of rabbit skeletal muscle sarcoplasmic reticulum: identification of sites labeled with aryl isothiocyanates and thiol-directed conformational probes."
      Wawrzynow A. , Collins J.H.
      Biochim. Biophys. Acta1203:60-70(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 335-365; 468-476; 493-502; 513-529; 606-615; 630-637 AND 668-671
    5. 5.
      "Interaction of 4-azido-2-nitrophenyl phosphate, a pseudosubstrate, with the sarcoplasmic reticulum Ca-ATPase."
      Lacapere J.J. , Garin J.
      Biochemistry33:2586-2593(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 506-513 AND 584-591
    6. 6.
      "Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle."
      Brandl C.J. , Deleon S. , Martin D.R. , McLennan D.H.
      J. Biol. Chem.262:3768-3774(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 973-1001 (ISOFORMS SERCA1A AND SERCA1B);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    7. 7.
      "Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution."
      Toyoshima C. , Nakasako M. , Nomura H. , Ogawa H.
      Nature405:647-655(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF ISOFORM SERCA1A
    8. 8.
      "Identification of regions in the Ca(2+)-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban."
      Toyofuku T. , Kurzydlowski K. , Tada M. , McLennan D.H.
      J. Biol. Chem.268:2809-2815(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHOSPHOLAMBAN
    9. 9.
      "Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sites."
      Asahi M. , Kimura Y. , Kurzydlowski K. , Tada M. , McLennan D.H.
      J. Biol. Chem.274:32855-32862(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHOSPHOLAMBAN
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