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Index > Protein center > ATP2B2(Gene name) > Human
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  • ATP2B2 (Gene name),
  • Plasma membrane calcium-transporting ATPase 2 (Protein name ),  AT2B2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    ATP2B2(PMCA2);
    Protein name:
    Plasma membrane calcium-transporting ATPase 2(PMCA2);
    Alternative:
    Plasma membrane calcium pump isoform 2;Plasma membrane calcium ATPase isoform 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1243
    Sequence:
    50:
    MGDMTNSDFY | SKNQRNESSH | GGEFGCTMEE | LRSLMELRGT | EAVVKIKETY | 
    100:
    GDTEAICRRL | KTSPVEGLPG | TAPDLEKRKQ | IFGQNFIPPK | KPKTFLQLVW | 
    150:
    EALQDVTLII | LEIAAIISLG | LSFYHPPGEG | NEGCATAQGG | AEDEGEAEAG | 
    200:
    WIEGAAILLS | VICVVLVTAF | NDWSKEKQFR | GLQSRIEQEQ | KFTVVRAGQV | 
    250:
    VQIPVAEIVV | GDIAQVKYGD | LLPADGLFIQ | GNDLKIDESS | LTGESDQVRK | 
    300:
    SVDKDPMLLS | GTHVMEGSGR | MLVTAVGVNS | QTGIIFTLLG | AGGEEEEKKD | 
    350:
    KKGVKKGDGL | QLPAADGAAA | SNAADSANAS | LVNGKMQDGN | VDASQSKAKQ | 
    400:
    QDGAAAMEMQ | PLKSAEGGDA | DDRKKASMHK | KEKSVLQGKL | TKLAVQIGKA | 
    450:
    GLVMSAITVI | ILVLYFTVDT | FVVNKKPWLP | ECTPVYVQYF | VKFFIIGVTV | 
    500:
    LVVAVPEGLP | LAVTISLAYS | VKKMMKDNNL | VRHLDACETM | GNATAICSDK | 
    550:
    TGTLTTNRMT | VVQAYVGDVH | YKEIPDPSSI | NTKTMELLIN | AIAINSAYTT | 
    600:
    KILPPEKEGA | LPRQVGNKTE | CGLLGFVLDL | KQDYEPVRSQ | MPEEKLYKVY | 
    650:
    TFNSVRKSMS | TVIKLPDESF | RMYSKGASEI | VLKKCCKILN | GAGEPRVFRP | 
    700:
    RDRDEMVKKV | IEPMACDGLR | TICVAYRDFP | SSPEPDWDNE | NDILNELTCI | 
    750:
    CVVGIEDPVR | PEVPEAIRKC | QRAGITVRMV | TGDNINTARA | IAIKCGIIHP | 
    800:
    GEDFLCLEGK | EFNRRIRNEK | GEIEQERIDK | IWPKLRVLAR | SSPTDKHTLV | 
    850:
    KGIIDSTHTE | QRQVVAVTGD | GTNDGPALKK | ADVGFAMGIA | GTDVAKEASD | 
    900:
    IILTDDNFSS | IVKAVMWGRN | VYDSISKFLQ | FQLTVNVVAV | IVAFTGACIT | 
    950:
    QDSPLKAVQM | LWVNLIMDTF | ASLALATEPP | TETLLLRKPY | GRNKPLISRT | 
    1000:
    MMKNILGHAV | YQLALIFTLL | FVGEKMFQID | SGRNAPLHSP | PSEHYTIIFN | 
    1050:
    TFVMMQLFNE | INARKIHGER | NVFDGIFRNP | IFCTIVLGTF | AIQIVIVQFG | 
    1100:
    GKPFSCSPLQ | LDQWMWCIFI | GLGELVWGQV | IATIPTSRLK | FLKEAGRLTQ | 
    1150:
    KEEIPEEELN | EDVEEIDHAE | RELRRGQILW | FRGLNRIQTQ | IRVVKAFRSS | 
    1200:
    LYEGLEKPES | RTSIHNFMAH | PEFRIEDSQP | HIPLIDDTDL | EEDAALKQNS | 
    1243:
    SPPSSLNKNN | SAIDSGINLT | TDTSKSATSS | SPGSPIHSLE | TSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human PMCA2
    Cat.:
    E12578m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PMCA2
    Cat.:
    E12578r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PMCA2
    Cat.:
    E12578h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PMCA2
    Cat.:
    U12578r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PMCA2
    Cat.:
    U12578m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PMCA2
    Cat.:
    U12578h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PMCA2
    Cat.:
    P12578Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PMCA2
    Cat.:
    P12578Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PMCA2
    Cat.:
    P12578Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PMCA2
    Monoclonal Antibody for Human PMCA2
    Monoclonal Antibody for Human PMCA2
    Protein for Human PMCA2
    Protein for Human PMCA2
    Protein for Human PMCA2

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    References
    1. 1.
      "Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2."
      Brandt P. , Ibrahim E. , Bruns G.A.P. , Neve R.L.
      Genomics14:484-487(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB)
      tissue: Brain.
    2. 2.
      "von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region."
      Latif F. , Duh F.-M. , Gnarra J. , Tory K. , Kuzmin I. , Yao M. , Stackhouse T. , Modi W. , Geil L. , Schmidt L. , Li H. , Orcutt M.L. , Maher E. , Richards F. , Phipps M. , Ferguson-Smith M. , le Paslier D. , Linehan W.M. , more...
      Cancer Res.53:861-867(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZB);ALTERNATIVE SPLICING
    3. 3.
      "Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region."
      Heim R. , Hug M. , Iwata T. , Strehler E.E. , Carafoli E.
      Eur. J. Biochem.205:333-340(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM WB);ALTERNATIVE SPLICING
      tissue: Brain.
      tissue: Skeletal muscle.
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."
      Stauffer T.P. , Hilfiker H. , Carafoli E. , Strehler E.E.
      J. Biol. Chem.268:25993-26003(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS WA/YA/ZA)
      tissue: Brain cortex.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants."
      Goellner G.M. , DeMarco S.J. , Strehler E.E.
      Ann. N. Y. Acad. Sci.986:461-471(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDZD11
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177 (ISOFORM WA);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146 (ISOFORM XA);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1163 (ISOFORM YA);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1132 (ISOFORM ZA);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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