Protein name:
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) ;
Alternative:
Activating transcription factor 4 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Interacts with the N-terminal region of CEP290. Forms a heterodimer with TXLNG in osteoblasts (By similarity). Interacts with NEK6.
Function:
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.
Subcellular Location:
Cytoplasm
Cell membrane
Nucleus
Cytoplasm
cytoskeleton
centrosome
Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Co-localizes with NEK6 in the centrosome.
Protein Attributes:
50:
MAEMSFLSSE | VLGGDFVSPF | DQLGLGAEES | LGLLDDNLEV | AKHFKHHGFS |
100:
CDKAKAGSSE | WLAVDWLVSD | NSKEDAFSGT | DWMVEKMDLK | EFDFDILFSK |
150:
DDLETMPDEL | LATLDDTCDL | FQPLVQETNK | EPPQIVNPIG | HLPEGLPTID |
200:
QGAPFTFFQP | LPPSPGTLSS | TPDHSFSLEL | CSEVVIPEGD | SKPDSTTTGF |
250:
PQCIKEEDAP | SDNDSGICMS | PDSSLGSPQD | SPSTSRGSPN | KSLLSPGALS |
300:
GSSRPKPYDP | PGEKMVAAKV | KGEKLDKKLK | KMEQNKTAAT | RYRQKKRAEQ |
348:
EALTGECKEL | EKKNEALKEK | ADSLAKEIQY | LKDQIEEVRK | AREKKRVL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
Rat
ELISA Kit for Bovine cAMP-dependent transcription factor ATF-4
ELISA Kit for Bovine cAMP-dependent transcription factor ATF-4
ELISA Kit for Bovine cAMP-dependent transcription factor ATF-4
ELISA Kit for Bovine cAMP-dependent transcription factor ATF-4
CLIA Kit for Bovine cAMP-dependent transcription factor ATF-4
CLIA Kit for Bovine cAMP-dependent transcription factor ATF-4
CLIA Kit for Bovine cAMP-dependent transcription factor ATF-4
CLIA Kit for Bovine cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Bovine cAMP-dependent transcription factor ATF-4
Protein for Bovine cAMP-dependent transcription factor ATF-4
Protein for Bovine cAMP-dependent transcription factor ATF-4
Protein for Bovine cAMP-dependent transcription factor ATF-4
Protein for Bovine cAMP-dependent transcription factor ATF-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Mammary gland .
2.
"The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4."
Sayer J.A.
,
Otto E.A.
,
O'toole J.F.
,
Nurnberg G.
,
Kennedy M.A.
,
Becker C.
,
Hennies H.C.
,
Helou J.
,
Attanasio M.
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Fausett B.V.
,
Utsch B.
,
Khanna H.
,
Liu Y.
,
Drummond I.
,
Kawakami I.
,
Kusakabe T.
,
Tsuda M.
,
Ma L.
,
Lee H.
,
Larson R.G.
,
Allen S.J.
,
Wilkinson C.J.
,
Nigg E.A.
,
Shou C.
,
Lillo C.
,
Williams D.S.
,
Hoppe B.
,
Kemper M.J.
,
Neuhaus T.
,
Parisi M.A.
,
Glass I.A.
,
Petry M.
,
Kispert A.
,
Gloy J.
,
Ganner A.
,
Walz G.
,
Zhu X.
,
Goldman D.
,
Nurnberg P.
,
Swaroop A.
,
Leroux M.R.
,
Hildebrandt F.
more...
Nat. Genet.38:674-681(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CEP290