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Index > Protein center > Atf6(Gene name) > Rat
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  • Atf6 (Gene name),
  • Cyclic AMP-dependent transcription factor ATF-6 alpha (Protein name ),  ATF6A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Atf6;
    Protein name:
    Cyclic AMP-dependent transcription factor ATF-6 alpha(cAMP-dependent transcription factor ATF-6 alpha);
    Alternative:
    Activating transcription factor 6 alpha(ATF6-alpha);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF. Interacts (via lumenal domain) with THBS1. Interacts with THBS4 (via EGF-like 3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation.
    Function:
    Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
    Subcellular Location:
    Cyclic AMP-dependent transcription factor ATF-6 alpha Nucleus Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.
    Protein Attributes:
    Sequence length:
    656
    Sequence:
    50:
    MESPFSPVLP | HGPGEDWEST | LFAELGYFTD | TDDVQFDAAH | ETYENNFDHL | 
    100:
    NFDLDLMPWE | SDIWSPSSHF | CSDIKAEPQP | LSPASSSCSV | SSPRSTDSCS | 
    150:
    STQHVPEELD | LLSSSQSPLS | LYGDSCHSPS | SAEPLKEEKP | VTGPGNKTEH | 
    200:
    GLTPKKKIQM | SSKPSVQPKP | LLLPAAPKTP | ANASVPAKTI | IIQTLPALMP | 
    250:
    LAKQQSIISI | QPAPTKGQTV | LLSQPAVVQL | QTPGVLPSAQ | PVLAVTGGAT | 
    300:
    QLPNHVVNVV | PAPVVNSPVN | GKLCVTKPVL | QSSTRSTGSD | IAVLRRQQRM | 
    350:
    IKNRESACQS | RKKKKEYMLG | LEARLKAALS | ENEQLKKENG | SLKRQLDQVV | 
    400:
    SENQRLKVPS | PKRRAVCVMI | VLAFIMLNYG | PMSMLEQDSR | RVKPSVSPAN | 
    450:
    QRRHLLEFSA | KEVKDTSDGD | NQKNSYRYDH | SVSNDKALMV | LSEEPLLYIP | 
    500:
    PPPCQPLINT | TESLRLNHEL | RGWVHRHEVE | RTKSRRMTNS | QQKTRILQGA | 
    550:
    LEQGSNSQLM | AVQYTETTSI | SRNSGSELQV | YYASPGSYQG | FFDAIRRRGD | 
    600:
    TFYVVSFRRD | HLLLPATTHN | KTTRPKMSIV | LPAININDNV | INGQDYEVMM | 
    650:
    QIDCQVMDTR | ILHIKSSSVP | PYLRDHQRNQ | TSTFFGSPPT | ATETTHVVST | 
    656:
    LPESVQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    ELISA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    ELISA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    CLIA Kit for Rat cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Polyclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Monoclonal Antibody for Rat cAMP-dependent transcription factor ATF-6 alpha
    Protein for Rat cAMP-dependent transcription factor ATF-6 alpha
    Protein for Rat cAMP-dependent transcription factor ATF-6 alpha
    Protein for Rat cAMP-dependent transcription factor ATF-6 alpha

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    Precision
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
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