ATG3 ELISA Kit for Human(Homo sapiens) | EIAab.comATG3 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ATG3 (Gene name),

Ubiquitin-like-conjugating enzyme ATG3 (Protein name ), ATG3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ATG3(APG3;APG3L);

Protein name:

Ubiquitin-like-conjugating enzyme ATG3;

Alternative:

Protein PC3-96;Autophagy-related protein 3(APG3-like;hApg3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.

Function:

E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

314

Sequence:

50:

MQNVINTVKG | KALEVAEYLT | PVLKESKFKE | TGVITPEEFV | AAGDHLVHHC |

100:

PTWQWATGEE | LKVKAYLPTG | KQFLVTKNVP | CYKRCKQMEY | SDELEAIIEE |

150:

DDGDGGWVDT | YHNTGITGIT | EAVKEITLEN | KDNIRLQDCS | ALCEEEEDED |

200:

EGEAADMEEY | EESGLLETDE | ATLDTRKIVE | ACKAKTDAGG | EDAILQTRTY |

250:

DLYITYDKYY | QTPRLWLFGY | DEQRQPLTVE | HMYEDISQDH | VKKTVTIENH |

300:

PHLPPPPMCS | VHPCRHAEVM | KKIIETVAEG | GGELGVHMYL | LIFLKFVQAV |

314:

IPTIEYDYTR | HFTM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

SMR:

Pfam:

String:

KEGG:

UniGene:

STRING:

9606.ENSP00000283290

Uniprot:

FOR

ELISA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

ELISA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

ELISA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

ELISA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

CLIA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

CLIA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

CLIA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

CLIA Kit for Human Ubiquitin-like-conjugating enzyme ATG3

Polyclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Polyclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Polyclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Polyclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Monoclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Monoclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Monoclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Monoclonal Antibody for Human Ubiquitin-like-conjugating enzyme ATG3

Protein for Human Ubiquitin-like-conjugating enzyme ATG3

Protein for Human Ubiquitin-like-conjugating enzyme ATG3

Protein for Human Ubiquitin-like-conjugating enzyme ATG3

Protein for Human Ubiquitin-like-conjugating enzyme ATG3

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
Tanida I. , Tanida-Miyake E. , Komatsu M. , Ueno T. , Kominami E.
J. Biol. Chem.277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;MUTAGENESIS OF CYS-264;SUBCELLULAR LOCATION;FUNCTION;ACTIVE SITE;INTERACTION WITH ATG7 AND ATG12
tissue: Brain.
2.

"Cloning and characterization of human PC3-96 gene."
Wu B.X. , Li Y. , Laser M. , Crosson C.E. , Hazard E.S. III , Ma J.X.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Retina.
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Lung.
tissue: Lymph.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-314 (ISOFORM 2)
6.

"Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing."
Tanida I. , Nishitani T. , Nemoto T. , Ueno T. , Kominami E.
Biochem. Biophys. Res. Commun.296:1164-1170(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THE ATG12-ATG5 CONJUGATE
7.

"The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification."
Nemoto T. , Tanida I. , Tanida-Miyake E. , Minematsu-Ikeguchi N. , Yokota M. , Ohsumi M. , Ueno T. , Kominami E.
J. Biol. Chem.278:39517-39526(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
9.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3."
Tanida I. , Sou Y.S. , Minematsu-Ikeguchi N. , Ueno T. , Kominami E.
FEBS J.273:2553-2562(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy."
Huett A. , Ng A. , Cao Z. , Kuballa P. , Komatsu M. , Daly M.J. , Podolsky D.K. , Xavier R.J.
J. Immunol.182:4917-4930(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FNBP1L
13.

"ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death."
Radoshevich L. , Murrow L. , Chen N. , Fernandez E. , Roy S. , Fung C. , Debnath J.
Cell142:590-600(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ATG12
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death."
Oral O. , Oz-Arslan D. , Itah Z. , Naghavi A. , Deveci R. , Karacali S. , Gozuacik D.
Apoptosis17:810-820(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;CLEAVAGE BY CASP8
16.

"The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation."
Tanida I. , Yamasaki M. , Komatsu M. , Ueno T.
Autophagy8:88-97(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3 AND ATG12
17.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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