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Index > Protein center > Atp5a1(Gene name) > Mouse
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  • Atp5a1 (Gene name),
  • ATP synthase subunit alpha, mitochondrial (Protein name ),  ATPA_MOUSE from NCBI database.
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  • Gene name:
    Atp5a1;
    Protein name:
    ATP synthase subunit alpha, mitochondrial;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin.
    Function:
    Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.
    Subcellular Location:
    Mitochondrion inner membrane Cell membrane Peripheral membrane protein Extracellular side Colocalizes with HRG on the cell surface of T-cells.
    Protein Attributes:
    Sequence length:
    553
    Sequence:
    50:
    MLSVRVAAAV | ARALPRRAGL | VSKNALGSSF | VGARNLHASN | TRLQKTGTAE | 
    100:
    MSSILEERIL | GADTSVDLEE | TGRVLSIGDG | IARVHGLRNV | QAEEMVEFSS | 
    150:
    GLKGMSLNLE | PDNVGVVVFG | NDKLIKEGDV | VKRTGAIVDV | PVGEELLGRV | 
    200:
    VDALGNAIDG | KGPIGSKTRR | RVGLKAPGII | PRISVREPMQ | TGIKAVDSLV | 
    250:
    PIGRGQRELI | IGDRQTGKTS | IAIDTIINQK | RFNDGTDEKK | KLYCIYVAIG | 
    300:
    QKRSTVAQLV | KRLTDADAMK | YTIVVSATAS | DAAPLQYLAP | YSGCSMGEYF | 
    350:
    RDNGKHALII | YDDLSKQAVA | YRQMSLLLRR | PPGREAYPGD | VFYLHSRLLE | 
    400:
    RAAKMNDSFG | GGSLTALPVI | ETQAGDVSAY | IPTNVISITD | GQIFLETELF | 
    450:
    YKGIRPAINV | GLSVSRVGSA | AQTRAMKQVA | GTMKLELAQY | REVAAFAQFG | 
    500:
    SDLDAATQQL | LSRGVRLTEL | LKQGQYSPMA | IEEQVAVIYA | GVRGYLDKLE | 
    550:
    PSKITKFENA | FLSHVISQHQ | SLLGNIRSDG | KISEQSDAKL | KEIVTNFLAG | 
    553:
    FEP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial
    Protein for Mouse ATP synthase subunit alpha, mitochondrial

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    References
    1. 1.
      "Cloning and functional expression analysis of the alpha subunit of mouse ATP synthase."
      Yotov W.V. , St Arnaud R.
      Biochem. Biophys. Res. Commun.191:142-148(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: BALB/c.
      strain: C57BL/6J.
      strain: NOD.
      tissue: Heart.
      tissue: Hippocampus.
      tissue: Liver.
      tissue: Spinal cord.
      tissue: Spleen.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    4. 4.
      Lubec G. , Kang S.U. , Klug S. , Yang J.W. , Zigmond M. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-42; 46-83; 89-123; 133-161; 176-182; 195-204; 208-214; 219-230; 241-252; 254-261; 263-270; 306-316; 323-329; 335-347; 403-416; 435-463; 467-503; 507-527 AND 540-553
      strain: C57BL/6.
      strain: OF1.
      tissue: Brain.
      tissue: Hippocampus.
    5. 5.
      "Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol."
      Vosseller K. , Hansen K.C. , Chalkley R.J. , Trinidad J.C. , Wells L. , Hart G.W. , Burlingame A.L.
      Proteomics5:388-398(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-498; LYS-531 AND LYS-539;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-161; LYS-167; LYS-230; LYS-239; LYS-261; LYS-305; LYS-427; LYS-498; LYS-506; LYS-531 AND LYS-539;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
      tissue: Liver.
    7. 7.
      "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123; LYS-126; LYS-132; LYS-161; LYS-167; LYS-230; LYS-239; LYS-240; LYS-261; LYS-305; LYS-427; LYS-434; LYS-498; LYS-506; LYS-531; LYS-539 AND LYS-541;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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