Protein name:
ATP synthase subunit alpha, mitochondrial ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin.
Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.
Subcellular Location:
Mitochondrion inner membrane
Cell membrane
Peripheral membrane protein
Extracellular side
Colocalizes with HRG on the cell surface of T-cells.
Protein Attributes:
50:
MLSVRVAAAV | ARALPRRAGL | VSKNALGSSF | VGARNLHASN | TRLQKTGTAE |
100:
MSSILEERIL | GADTSVDLEE | TGRVLSIGDG | IARVHGLRNV | QAEEMVEFSS |
150:
GLKGMSLNLE | PDNVGVVVFG | NDKLIKEGDV | VKRTGAIVDV | PVGEELLGRV |
200:
VDALGNAIDG | KGPIGSKTRR | RVGLKAPGII | PRISVREPMQ | TGIKAVDSLV |
250:
PIGRGQRELI | IGDRQTGKTS | IAIDTIINQK | RFNDGTDEKK | KLYCIYVAIG |
300:
QKRSTVAQLV | KRLTDADAMK | YTIVVSATAS | DAAPLQYLAP | YSGCSMGEYF |
350:
RDNGKHALII | YDDLSKQAVA | YRQMSLLLRR | PPGREAYPGD | VFYLHSRLLE |
400:
RAAKMNDSFG | GGSLTALPVI | ETQAGDVSAY | IPTNVISITD | GQIFLETELF |
450:
YKGIRPAINV | GLSVSRVGSA | AQTRAMKQVA | GTMKLELAQY | REVAAFAQFG |
500:
SDLDAATQQL | LSRGVRLTEL | LKQGQYSPMA | IEEQVAVIYA | GVRGYLDKLE |
550:
PSKITKFENA | FLSHVISQHQ | SLLGNIRSDG | KISEQSDAKL | KEIVTNFLAG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Pig
Bovine
Pig
Mouse
Human
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
ELISA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
CLIA Kit for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Polyclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Monoclonal Antibody for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
Protein for Mouse ATP synthase subunit alpha, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
BALB/c .
strain :
C57BL/6J .
strain :
NOD .
tissue :
Heart .
tissue :
Hippocampus .
tissue :
Liver .
tissue :
Spinal cord .
tissue :
Spleen .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-42; 46-83; 89-123; 133-161; 176-182; 195-204; 208-214; 219-230; 241-252; 254-261; 263-270; 306-316; 323-329; 335-347; 403-416; 435-463; 467-503; 507-527 AND 540-553
strain :
C57BL/6 .
strain :
OF1 .
tissue :
Brain .
tissue :
Hippocampus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
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,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-498; LYS-531 AND LYS-539;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-161; LYS-167; LYS-230; LYS-239; LYS-261; LYS-305; LYS-427; LYS-498; LYS-506; LYS-531 AND LYS-539;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
tissue :
Liver .
7.
"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J.
,
Newman J.C.
,
Held J.M.
,
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,
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,
Li B.
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,
Mooney S.D.
,
Kahn C.R.
,
Verdin E.
,
Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123; LYS-126; LYS-132; LYS-161; LYS-167; LYS-230; LYS-239; LYS-240; LYS-261; LYS-305; LYS-427; LYS-434; LYS-498; LYS-506; LYS-531; LYS-539 AND LYS-541;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .