Gene name:
AGTRAP (ATRAP) ;
Protein name:
Type-1 angiotensin II receptor-associated protein ;
Alternative:
AT1 receptor-associated protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Golgi apparatus membrane
Multi-pass membrane protein
Cytoplasmic vesicle membrane
Multi-pass membrane protein
Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Protein Attributes:
50:
MELPAVNLKV | ILLGHWLLTT | WGCIVFSGSY | AWANFTILAL | GVWAVAQRDS |
100:
IDAISMFLGG | LLATIFLDIV | HISIFYPRVS | LTDTGRFGVG | MAILSLLLKP |
150:
LSCCFVYHMY | RERGGELLVH | TGFLGSSQDR | SAYQTIDSAE | APADPFAVPE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
Protein for Human Type-1 angiotensin II receptor-associated protein
Protein for Human Type-1 angiotensin II receptor-associated protein
Protein for Human Type-1 angiotensin II receptor-associated protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH GNB2L1 AND AGTR1
tissue :
Fetal brain .
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Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Kidney .
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Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue :
Pancreas islet cell .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-143
5.
"The DNA sequence and biological annotation of human chromosome 1."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5)
tissue :
Colon .
tissue :
Eye .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AGTR1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]