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Index > Protein center > AGTRAP(Gene name) > Human
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  • AGTRAP (Gene name),
  • Type-1 angiotensin II receptor-associated protein (Protein name ),  ATRAP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AGTRAP(ATRAP);
    Protein name:
    Type-1 angiotensin II receptor-associated protein;
    Alternative:
    AT1 receptor-associated protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
    Function:
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cytoplasmic vesicle membrane Multi-pass membrane protein Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
    Protein Attributes:
    Sequence length:
    159
    Sequence:
    50:
    MELPAVNLKV | ILLGHWLLTT | WGCIVFSGSY | AWANFTILAL | GVWAVAQRDS | 
    100:
    IDAISMFLGG | LLATIFLDIV | HISIFYPRVS | LTDTGRFGVG | MAILSLLLKP | 
    150:
    LSCCFVYHMY | RERGGELLVH | TGFLGSSQDR | SAYQTIDSAE | APADPFAVPE | 
    159:
    GRSQDARGY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
    ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
    ELISA Kit for Human Type-1 angiotensin II receptor-associated protein
    CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
    CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
    CLIA Kit for Human Type-1 angiotensin II receptor-associated protein
    Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Polyclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Monoclonal Antibody for Human Type-1 angiotensin II receptor-associated protein
    Protein for Human Type-1 angiotensin II receptor-associated protein
    Protein for Human Type-1 angiotensin II receptor-associated protein
    Protein for Human Type-1 angiotensin II receptor-associated protein

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."
      Wang W. , Huang Y. , Zhou Z. , Tang R. , Zhao W. , Zeng L. , Xu M. , Cheng C. , Gu S. , Ying K. , Xie Y. , Mao Y.
      Int. J. Biochem. Cell Biol.34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH GNB2L1 AND AGTR1
      tissue: Fetal brain.
    2. 2.
      Ye R.D. , He R.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Kidney.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Pancreas islet cell.
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-143
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5)
      tissue: Colon.
      tissue: Eye.
    8. 8.
      "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."
      Lopez-Ilasaca M. , Liu X. , Tamura K. , Dzau V.J.
      Mol. Biol. Cell14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH AGTR1
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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