AURKA ELISA Kit for Human(Homo sapiens) | EIAab.comAURKA ELISA Kit for Human(Homo sapiens)

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AURKA (Gene name),

Aurora kinase A (Protein name ), AURKA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

AURKA(AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6);

Protein name:

Aurora kinase A;

Alternative:

Aurora/IPL1-related kinase 1(ARK-1;Aurora-related kinase 1;hARK1);Aurora 2;Serine/threonine-protein kinase 15;Breast tumor-amplified kinase;Serine/threonine-protein kinase aurora-A;Serine/threonine-protein kinase 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1.

Function:

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity.

Subcellular Location:

Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle pole Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles.

Protein Attributes:

Sequence length:

403

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

403:

KQS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O14965

KEGG:

hsa:6790

STRING:

9606.ENSP00000216911

MIM:

603072

UniGene:

Hs.250822

Pfam:

PF00069

String:

O14965

Uniprot:

O14965

FOR

ELISA Kit for Human Aurora kinase A

CLIA Kit for Human Aurora kinase A

Polyclonal Antibody for Human Aurora kinase A

Monoclonal Antibody for Human Aurora kinase A

Protein for Human Aurora kinase A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1."
Kimura M. , Kotani S. , Hattori T. , Sumi N. , Yoshioka T. , Todokoro K. , Okano Y.
J. Biol. Chem.272:13766-13771(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;SUBCELLULAR LOCATION
tissue: Blood.
2.

"cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2."
Shindo M. , Nakano H. , Kuroyanagi H. , Shirasawa T. , Mihara M. , Gilbert D.J. , Jenkins N.A. , Copeland N.G. , Yagita H. , Okumura K.
Biochem. Biophys. Res. Commun.244:285-292(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ILE-57
3.

"Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation."
Zhou H. , Kuang J. , Zhong L. , Kuo W.-L. , Gray J.W. , Sahin A. , Brinkley B.R. , Sen S.
Nat. Genet.20:189-193(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ILE-31
tissue: Mammary gland.
4.

"Mutational analysis of the STK15 gene in human tumors."
Wang L. , Thibodeau S.N.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Cervix.
tissue: Colon.
tissue: Kidney.
tissue: Muscle.
8.

"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers."
Bischoff J.R. , Anderson L. , Zhu Y. , Mossie K. , Ng L. , Souza B. , Schryver B. , Flanagan P. , Clairvoyant F. , Ginther C. , Chan C.S. , Novotny M. , Slamon D.J. , Plowman G.D.
EMBO J.17:3052-3065(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;FUNCTION;SUBCELLULAR LOCATION
9.

"Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway."
Honda K. , Mihara H. , Kato Y. , Yamaguchi A. , Tanaka H. , Yasuda H. , Furukawa K. , Urano T.
Oncogene19:2812-2819(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;PROTEASOMAL DEGRADATION;MUTAGENESIS OF ARG-205
10.

"The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation."
Walter A.O. , Seghezzi W. , Korver W. , Sheung J. , Lees E.
Oncogene19:4906-4916(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-288;MUTAGENESIS OF THR-288;UBIQUITINATION;ENZYME REGULATION
11.

"Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle."
Katayama H. , Zhou H. , Li Q. , Tatsuka M. , Sen S.
J. Biol. Chem.276:46219-46224(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1CA; PPP1CB AND PPP1CC;MUTAGENESIS OF PHE-165 AND PHE-346;PHOSPHORYLATION
12.

"Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalpha."
Sugimoto K. , Urano T. , Zushi H. , Inoue K. , Tasaka H. , Tachibana M. , Dotsu M.
Cell Struct. Funct.27:457-467(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
13.

"Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells."
Marumoto T. , Hirota T. , Morisaki T. , Kunitoku N. , Zhang D. , Ichikawa Y. , Sasayama T. , Kuninaka S. , Mimori T. , Tamaki N. , Kimura M. , Okano Y. , Saya H.
Genes Cells7:1173-1182(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;PHOSPHORYLATION;ENZYME REGULATION
14.

"Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1."
Tanaka M. , Ueda A. , Kanamori H. , Ideguchi H. , Yang J. , Kitajima S. , Ishigatsubo Y.
J. Biol. Chem.277:10719-10726(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
15.

"Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells."
Hirota T. , Kunitoku N. , Sasayama T. , Marumoto T. , Zhang D. , Nitta M. , Hatakeyama K. , Saya H.
Cell114:585-598(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-288
16.

"Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells."
Marumoto T. , Honda S. , Hara T. , Nitta M. , Hirota T. , Kohmura E. , Saya H.
J. Biol. Chem.278:51786-51795(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"TACC1-chTOG-Aurora A protein complex in breast cancer."
Conte N. , Delaval B. , Ginestier C. , Ferrand A. , Isnardon D. , Larroque C. , Prigent C. , Seraphin B. , Jacquemier J. , Birnbaum D.
Oncogene22:8102-8116(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TACC1
18.

"The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase."
Toji S. , Yabuta N. , Hosomi T. , Nishihara S. , Kobayashi T. , Suzuki S. , Tamai K. , Nojima H.
Genes Cells9:383-397(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition."
Ouchi M. , Fujiuchi N. , Sasai K. , Katayama H. , Minamishima Y.A. , Ongusaha P.P. , Deng C. , Sen S. , Lee S.W. , Ouchi T.
J. Biol. Chem.279:19643-19648(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRCA1;PHOSPHORYLATION AT THR-288;MUTAGENESIS OF LYS-162
20.

"Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."
Dutertre S. , Cazales M. , Quaranta M. , Froment C. , Trabut V. , Dozier C. , Mirey G. , Bouche J.P. , Theis-Febvre N. , Schmitt E. , Monsarrat B. , Prigent C. , Ducommun B.
J. Cell Sci.117:2523-2531(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53."
Katayama H. , Sasai K. , Kawai H. , Yuan Z.M. , Bondaruk J. , Suzuki F. , Fujii S. , Arlinghaus R.B. , Czerniak B.A. , Sen S.
Nat. Genet.36:55-62(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-162;INTERACTION WITH TP53
22.

"Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1."
Sasayama T. , Marumoto T. , Kunitoku N. , Zhang D. , Tamaki N. , Kohmura E. , Saya H. , Hirota T.
Genes Cells10:627-638(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CPEB1
23.

"The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A."
Zhao Z.S. , Lim J.P. , Ng Y.W. , Lim L. , Manser E.
Mol. Cell20:237-249(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-288 AND SER-342
24.

"Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A."
Yu C.T. , Hsu J.M. , Lee Y.C. , Tsou A.P. , Chou C.K. , Huang C.Y.
Mol. Cell. Biol.25:5789-5800(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;FUNCTION
25.

"Mitotic activation of the kinase Aurora-A requires its binding partner Bora."
Hutterer A. , Berdnik D. , Wirtz-Peitz F. , Zigman M. , Schleiffer A. , Knoblich J.A.
Dev. Cell11:147-157(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BORA
26.

"Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation."
Sankaran S. , Crone D.E. , Palazzo R.E. , Parvin J.D.
Cancer Res.67:11186-11194(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"HEF1-dependent Aurora A activation induces disassembly of the primary cilium."
Pugacheva E.N. , Jablonski S.A. , Hartman T.R. , Henske E.P. , Golemis E.A.
Cell129:1351-1363(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases."
Birkenfeld J. , Nalbant P. , Bohl B.P. , Pertz O. , Hahn K.M. , Bokoch G.M.
Dev. Cell12:699-712(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF2
29.

"Functional interaction of Aurora-A and PP2A during mitosis."
Horn V. , Thelu J. , Garcia A. , Albiges-Rizo C. , Block M.R. , Viallet J.
Mol. Biol. Cell18:1233-1241(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PPP2CA;PHOSPHORYLATION AT SER-51
30.

"Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis."
North B.J. , Verdin E.
PLoS ONE2:E784-E784(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT2;SUBCELLULAR LOCATION
31.

"Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase."
Manfredi M.G. , Ecsedy J.A. , Meetze K.A. , Balani S.K. , Burenkova O. , Chen W. , Galvin K.M. , Hoar K.M. , Huck J.J. , LeRoy P.J. , Ray E.T. , Sells T.B. , Stringer B. , Stroud S.G. , Vos T.J. , Weatherhead G.S. , Wysong D.R. , Zhang M. , more...
Proc. Natl. Acad. Sci. U.S.A.104:4106-4111(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
32.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
33.

"Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery."
Macurek L. , Lindqvist A. , Lim D. , Lampson M.A. , Klompmaker R. , Freire R. , Clouin C. , Taylor S.S. , Yaffe M.B. , Medema R.H.
Nature455:119-123(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
34.

"Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora A and regulates its function in neuronal polarity."
Khazaei M.R. , Puschel A.W.
J. Biol. Chem.284:33571-33579(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION;INTERACTION WITH PARD3
35.

"Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a."
Jang C.Y. , Coppinger J.A. , Seki A. , Yates J.R. III , Fang G.
J. Cell Sci.122:1334-1341(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KIF2A
36.

"An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics."
Mori D. , Yamada M. , Mimori-Kiyosue Y. , Shirai Y. , Suzuki A. , Ohno S. , Saya H. , Wynshaw-Boris A. , Hirotsune S.
Nat. Cell Biol.11:1057-1068(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TPX2;PHOSPHORYLATION AT THR-287 AND THR-288;MUTAGENESIS OF THR-287
37.

"A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function."
Fu J. , Bian M. , Liu J. , Jiang Q. , Zhang C.
Proc. Natl. Acad. Sci. U.S.A.106:6939-6944(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TPX2;MUTAGENESIS OF GLY-198;SUBCELLULAR LOCATION;FUNCTION
38.

"Pitchfork regulates primary cilia disassembly and left-right asymmetry."
Kinzel D. , Boldt K. , Davis E.E. , Burtscher I. , Trumbach D. , Diplas B. , Attie-Bitach T. , Wurst W. , Katsanis N. , Ueffing M. , Lickert H.
Dev. Cell19:66-77(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIFO;ACTIVATION BY PIFO
39.

"Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation."
Lieu A.S. , Cheng T.S. , Chou C.H. , Wu C.H. , Hsu C.Y. , Huang C.Y. , Chang L.K. , Loh J.K. , Chang C.S. , Hsu C.M. , Howng S.L. , Hong Y.R.
Int. J. Oncol.37:429-436(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AUNIP
40.

"Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase."
Sanchez R. , Pantoja-Uceda D. , Prieto J. , Diercks T. , Marcaida M.J. , Montoya G. , Campos-Olivas R. , Blanco F.J.
J. Biol. Chem.285:22196-22201(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GADD45A
41.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
42.

"PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
Platica M. , Ionescu A. , Ivan E. , Holland J.F. , Mandeli J. , Platica O.
Int. J. Oncol.38:777-785(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH JTB
43.

"The cellular geography of aurora kinases."
Carmena M. , Earnshaw W.C.
Nat. Rev. Mol. Cell Biol.4:842-854(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
44.

"Aurora A, centrosome structure, and the centrosome cycle."
Lukasiewicz K.B. , Lingle W.L.
Environ. Mol. Mutagen.50:602-619(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
45.

"SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."
Kim H.S. , Vassilopoulos A. , Wang R.H. , Lahusen T. , Xiao Z. , Xu X. , Li C. , Veenstra T.D. , Li B. , Yu H. , Ji J. , Wang X.W. , Park S.H. , Cha Y.I. , Gius D. , Deng C.X.
Cancer Cell20:487-499(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT2;SUBCELLULAR LOCATION
46.

"Furry protein promotes Aurora A-mediated polo-like kinase 1 activation."
Ikeda M. , Chiba S. , Ohashi K. , Mizuno K.
J. Biol. Chem.287:27670-27681(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRY
47.

"Crystal structure of aurora-2, an oncogenic serine/threonine kinase."
Cheetham G.M. , Knegtel R.M. , Coll J.T. , Renwick S.B. , Swenson L. , Weber P. , Lippke J.A. , Austen D.A.
J. Biol. Chem.277:42419-42422(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 107-403 IN COMPLEX WITH ADENOSINE;CATALYTIC ACTIVITY
48.

"Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography."
Nowakowski J. , Cronin C.N. , McRee D.E. , Knuth M.W. , Nelson C.G. , Pavletich N.P. , Rogers J. , Sang B.C. , Scheibe D.N. , Swanson R.V. , Thompson D.A.
Structure10:1659-1667(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 125-391 IN COMPLEX WITH ADP
49.

"Structural basis of Aurora-A activation by TPX2 at the mitotic spindle."
Bayliss R. , Sardon T. , Vernos I. , Conti E.
Mol. Cell12:851-862(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 122-403 IN COMPLEX WITH TPX2;MUTAGENESIS OF ASP-274;ACTIVE SITE;PHOSPHORYLATION AT THR-287 AND THR-288
50.

"SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors."
Heron N.M. , Anderson M. , Blowers D.P. , Breed J. , Eden J.M. , Green S. , Hill G.B. , Johnson T. , Jung F.H. , McMiken H.H. , Mortlock A.A. , Pannifer A.D. , Pauptit R.A. , Pink J. , Roberts N.J. , Rowsell S.
Bioorg. Med. Chem. Lett.16:1320-1323(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 123-401 IN COMPLEXES WITH ADPNP AND 5-AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR;CATALYTIC ACTIVITY
51.

"1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile."
Fancelli D. , Moll J. , Varasi M. , Bravo R. , Artico R. , Berta D. , Bindi S. , Cameron A. , Candiani I. , Cappella P. , Carpinelli P. , Croci W. , Forte B. , Giorgini M.L. , Klapwijk J. , Marsiglio A. , Pesenti E. , Rocchetti M. , more...
J. Med. Chem.49:7247-7251(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 100-403 IN COMPLEXES WITH SYNTHETIC INHIBITORS;FUNCTION
52.

"Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2."
Zhao B. , Smallwood A. , Yang J. , Koretke K. , Nurse K. , Calamari A. , Kirkpatrick R.B. , Lai Z.
Protein Sci.17:1791-1797(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 125-391 IN COMPLEX WITH VX-680 AND TPX2;PHOSPHORYLATION AT THR-288;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT
53.

"A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2."
Bibby R.A. , Tang C. , Faisal A. , Drosopoulos K. , Lubbe S. , Houlston R. , Bayliss R. , Linardopoulos S.
J. Biol. Chem.284:33177-33184(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 127-388 IN COMPLEX WITH ADP;CHARACTERIZATION OF VARIANTS ARG-155 AND MET-174;INTERACTION WITH TPX2
54.

"Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity."
Coumar M.S. , Leou J.S. , Shukla P. , Wu J.S. , Dixit A.K. , Lin W.H. , Chang C.Y. , Lien T.W. , Tan U.K. , Chen C.H. , Hsu J.T. , Chao Y.S. , Wu S.Y. , Hsieh H.P.
J. Med. Chem.52:1050-1062(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 123-401 IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY
55.

"A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B."
Aliagas-Martin I. , Burdick D. , Corson L. , Dotson J. , Drummond J. , Fields C. , Huang O.W. , Hunsaker T. , Kleinheinz T. , Krueger E. , Liang J. , Moffat J. , Phillips G. , Pulk R. , Rawson T.E. , Ultsch M. , Walker L. , Wiesmann C. , more...
J. Med. Chem.52:3300-3307(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 125-391 IN COMPLEX WITH SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY
56.

"Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk."
Kimura M.T. , Mori T. , Conroy J. , Nowak N.J. , Satomi S. , Tamai K. , Nagase H.
Cancer Res.65:3548-3554(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-31 AND ILE-57
57.

"Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese."
Chen L. , Ao X. , Ren Q. , Wang Z.N. , Lu C. , Xu Y. , Jiang L. , Luo Y. , Xu H.M. , Zhang X.
Yi Chuan Xue Bao32:331-336(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-31 AND ILE-57
58.

"Aurora kinases A and B and familial breast cancer risk."
Tchatchou S. , Wirtenberger M. , Hemminki K. , Sutter C. , Meindl A. , Wappenschmidt B. , Kiechle M. , Bugert P. , Schmutzler R.K. , Bartram C.R. , Burwinkel B.
Cancer Lett.247:266-272(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-31
59.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-31; LEU-50; ILE-57; ARG-155; MET-174 AND VAL-373

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