AURKC ELISA Kit for Human(Homo sapiens) | EIAab.comAURKC ELISA Kit for Human(Homo sapiens) | EIAab.com

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AURKC (Gene name),

Aurora kinase C (Protein name ), AURKC_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

AURKC(AIE2;AIK3;AIRK3;ARK3;STK13);

Protein name:

Aurora kinase C;

Alternative:

Aurora/IPL1-related kinase 3(ARK-3;Aurora-related kinase 3);Aurora 3;Serine/threonine-protein kinase 13;Aurora/IPL1/Eg2 protein 2;Serine/threonine-protein kinase aurora-C;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

Function:

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Subcellular Location:

Nucleus Chromosome Chromosome centromere Cytoplasm cytoskeleton spindle Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Protein Attributes:

Sequence length:

309

Sequence:

50:

MSSPRAVVQL | GKAQPAGEEL | ATANQTAQQP | SSPAMRRLTV | DDFEIGRPLG |

100:

KGKFGNVYLA | RLKESHFIVA | LKVLFKSQIE | KEGLEHQLRR | EIEIQAHLQH |

150:

PNILRLYNYF | HDARRVYLIL | EYAPRGELYK | ELQKSEKLDE | QRTATIIEEL |

200:

ADALTYCHDK | KVIHRDIKPE | NLLLGFRGEV | KIADFGWSVH | TPSLRRKTMC |

250:

GTLDYLPPEM | IEGRTYDEKV | DLWCIGVLCY | ELLVGYPPFE | SASHSETYRR |

300:

ILKVDVRFPL | SMPLGARDLI | SRLLRYQPLE | RLPLAQILKH | PWVQAHSRRV |

309:

LPPCAQMAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

UniGene:

SMR:

KEGG:

STRING:

9606.ENSP00000302898

Pfam:

String:

Uniprot:

FOR

ELISA Kit for Human Aurora kinase C

ELISA Kit for Human Aurora kinase C

CLIA Kit for Human Aurora kinase C

CLIA Kit for Human Aurora kinase C

Polyclonal Antibody for Human Aurora kinase C

Polyclonal Antibody for Human Aurora kinase C

Monoclonal Antibody for Human Aurora kinase C

Monoclonal Antibody for Human Aurora kinase C

Protein for Human Aurora kinase C

Protein for Human Aurora kinase C

R&D Technical Data

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Precision

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."
Tseng T.-C. , Chen S.-H. , Hsu Y.-P.P. , Tang T.K.
DNA Cell Biol.17:823-833(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
tissue: Testis.
2.

"Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter."
Bernard M. , Sanseau P. , Henry C. , Couturier A. , Prigent C.
Genomics53:406-409(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Placenta.
3.

"Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3."
Kimura M. , Matsuda Y. , Yoshioka T. , Okano Y.
J. Biol. Chem.274:7334-7340(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;SUBCELLULAR LOCATION
tissue: Testis.
4.

"Cloning and characterization of a novel human Aurora C splicing variant."
Yan X. , Wu Y. , Li Q. , Cao L. , Liu X. , Saiyin H. , Yu L.
Biochem. Biophys. Res. Commun.328:353-361(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY;FUNCTION;MUTAGENESIS OF THR-198;SUBCELLULAR LOCATION
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
8.

"Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells."
Sasai K. , Katayama H. , Stenoien D.L. , Fujii S. , Honda R. , Kimura M. , Okano Y. , Tatsuka M. , Suzuki F. , Nigg E.A. , Earnshaw W.C. , Brinkley W.R. , Sen S.
Cell Motil. Cytoskeleton59:249-263(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH INCENP;MUTAGENESIS OF LYS-72
9.

"Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C."
Li X. , Sakashita G. , Matsuzaki H. , Sugimoto K. , Kimura K. , Hanaoka F. , Taniguchi H. , Furukawa K. , Urano T.
J. Biol. Chem.279:47201-47211(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CDC COMPLEX;SUBCELLULAR LOCATION;ENZYME REGULATION;FUNCTION;MUTAGENESIS OF LYS-72 AND THR-198
10.

"Aurora C is directly associated with Survivin and required for cytokinesis."
Yan X. , Cao L. , Li Q. , Wu Y. , Zhang H. , Saiyin H. , Liu X. , Zhang X. , Shi Q. , Yu L.
Genes Cells10:617-626(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CDC COMPLEX;INTERACTION WITH BIRC5;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF ASP-166
11.

"Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility."
Dieterich K. , Soto Rifo R. , Faure A.K. , Hennebicq S. , Ben Amar B. , Zahi M. , Perrin J. , Martinez D. , Sele B. , Jouk P.-S. , Ohlmann T. , Rousseaux S. , Lunardi J. , Ray P.F.
Nat. Genet.39:661-665(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SPGF5
12.

"Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein."
Gabillard J.C. , Ulisse S. , Baldini E. , Sorrenti S. , Cremet J.Y. , Coccaro C. , Prigent C. , D'Armiento M. , Arlot-Bonnemains Y.
Biochem. Biophys. Res. Commun.408:647-653(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TACC1
13.

"A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development."
Avo Santos M. , van de Werken C. , de Vries M. , Jahr H. , Vromans M.J. , Laven J.S. , Fauser B.C. , Kops G.J. , Lens S.M. , Baart E.B.
Hum. Reprod.26:1868-1881(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
14.

"A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis."
Ben Khelifa M. , Zouari R. , Harbuz R. , Halouani L. , Arnoult C. , Lunardi J. , Ray P.F.
Mol. Hum. Reprod.17:762-768(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SPGF5
15.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-52; GLN-148 AND GLN-244

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