Aurkc ELISA Kit for Mouse(Mus musculus) | EIAab.comAurkc ELISA Kit for Mouse(Mus musculus)

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Aurkc (Gene name),

Aurora kinase C (Protein name ), AURKC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aurkc(Aie1;Aik3;Airk3;Ark3;Stk13);

Protein name:

Aurora kinase C;

Alternative:

Aurora/IPL1-related kinase 3(ARK-3;Aurora-related kinase 3);Aurora 3;Serine/threonine-protein kinase 13;Aurora/IPL1/Eg2 protein 1;Serine/threonine-protein kinase aurora-C;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP (By similarity). Interacts with TACC1.

Function:

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Subcellular Location:

Nucleus Chromosome Chromosome centromere Cytoplasm cytoskeleton spindle Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Protein Attributes:

Sequence length:

282

Sequence:

50:

100:

150:

200:

250:

282:

PSERLSLAQV | LKHPWVREHS | RRVLPPCVHG | AS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00069

String:

O88445

SMR:

O88445

UniGene:

Mm.261572

Uniprot:

O88445

FOR

ELISA Kit for Mouse Aurora kinase C

CLIA Kit for Mouse Aurora kinase C

Polyclonal Antibody for Mouse Aurora kinase C

Monoclonal Antibody for Mouse Aurora kinase C

Protein for Mouse Aurora kinase C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."
Tseng T.-C. , Chen S.-H. , Hsu Y.-P.P. , Tang T.K.
DNA Cell Biol.17:823-833(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
2.

"Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1."
Hu H.M. , Chuang C.K. , Lee M.J. , Tseng T.C. , Tang T.K.
DNA Cell Biol.19:679-688(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129.
3.

"Mutational analysis of the phosphorylation sites of the Aie1 (Aurora-C) kinase in vitro."
Chen S.H. , Tang T.K.
DNA Cell Biol.21:41-46(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF THR-171 AND THR-175;PHOSPHORYLATION AT THR-171 BY PKA
4.

"Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development."
Fernandez-Miranda G. , Trakala M. , Martin J. , Escobar B. , Gonzalez A. , Ghyselinck N.B. , Ortega S. , Canamero M. , de Castro I.P. , Malumbres M.
Development138:2661-2672(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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