Protein name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (BGnT-5;Beta-1,3-Gn-T5;Beta-1,3-N-acetylglucosaminyltransferase 5;Beta3Gn-T5) ;
Alternative:
UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5 (BGnT-5) ;Lactotriaosylceramide synthase (Lc(3)Cer synthase;Lc3 synthase) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Subcellular Location:
Golgi apparatus membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MRMLVSGRRV | KKWQLIIQLF | ATCFLASLMF | FWEPIDNHIV | SHMKSYSYRY |
100:
LINSYDFVND | TLSLKHTSAG | PRYQYLINHK | EKCQAQDVLL | LLFVKTAPEN |
150:
YDRRSGIRRT | WGNENYVRSQ | LNANIKTLFA | LGTPNPLEGE | ELQRKLAWED |
200:
QRYNDIIQQD | FVDSFYNLTL | KLLMQFSWAN | TYCPHAKFLM | TADDDIFIHM |
250:
PNLIEYLQSL | EQIGVQDFWI | GRVHRGAPPI | RDKSSKYYVS | YEMYQWPAYP |
300:
DYTAGAAYVI | SGDVAAKVYE | ASQTLNSSLY | IDDVFMGLCA | NKIGIVPQDH |
350:
VFFSGEGKTP | YHPCIYEKMM | TSHGHLEDLQ | DLWKNATDPK | VKTISKGFFG |
378:
QIYCRLMKII | LLCKISYVDT | YPCRAAFI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
ELISA Kit for Human BGnT-5
ELISA Kit for Human BGnT-5
ELISA Kit for Human BGnT-5
ELISA Kit for Human BGnT-5
CLIA Kit for Human BGnT-5
CLIA Kit for Human BGnT-5
CLIA Kit for Human BGnT-5
CLIA Kit for Human BGnT-5
Polyclonal Antibody for Human BGnT-5
Polyclonal Antibody for Human BGnT-5
Polyclonal Antibody for Human BGnT-5
Polyclonal Antibody for Human BGnT-5
Monoclonal Antibody for Human BGnT-5
Monoclonal Antibody for Human BGnT-5
Monoclonal Antibody for Human BGnT-5
Monoclonal Antibody for Human BGnT-5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids."
Togayachi A.
,
Akashima T.
,
Ookubo R.
,
Kudo T.
,
Nishihara S.
,
Iwasaki H.
,
Natsume A.
,
Mio H.
,
Inokuchi J.
,
Irimura T.
,
Sasaki K.
,
Narimatsu H.
J. Biol. Chem.276:22032-22040(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;TISSUE SPECIFICITY;INDUCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
Bennett E.P.
Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
5.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .