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Index > Protein center > B3GNT5(Gene name) > Human
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  • B3GNT5 (Gene name),
  • UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (Protein name ),  B3GN5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    B3GNT5;
    Protein name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5(BGnT-5;Beta-1,3-Gn-T5;Beta-1,3-N-acetylglucosaminyltransferase 5;Beta3Gn-T5);
    Alternative:
    UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5(BGnT-5);Lactotriaosylceramide synthase(Lc(3)Cer synthase;Lc3 synthase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
    Subcellular Location:
    Golgi apparatus membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    378
    Sequence:
    50:
    MRMLVSGRRV | KKWQLIIQLF | ATCFLASLMF | FWEPIDNHIV | SHMKSYSYRY | 
    100:
    LINSYDFVND | TLSLKHTSAG | PRYQYLINHK | EKCQAQDVLL | LLFVKTAPEN | 
    150:
    YDRRSGIRRT | WGNENYVRSQ | LNANIKTLFA | LGTPNPLEGE | ELQRKLAWED | 
    200:
    QRYNDIIQQD | FVDSFYNLTL | KLLMQFSWAN | TYCPHAKFLM | TADDDIFIHM | 
    250:
    PNLIEYLQSL | EQIGVQDFWI | GRVHRGAPPI | RDKSSKYYVS | YEMYQWPAYP | 
    300:
    DYTAGAAYVI | SGDVAAKVYE | ASQTLNSSLY | IDDVFMGLCA | NKIGIVPQDH | 
    350:
    VFFSGEGKTP | YHPCIYEKMM | TSHGHLEDLQ | DLWKNATDPK | VKTISKGFFG | 
    378:
    QIYCRLMKII | LLCKISYVDT | YPCRAAFI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human BGnT-5
    ELISA Kit for Human BGnT-5
    ELISA Kit for Human BGnT-5
    ELISA Kit for Human BGnT-5
    CLIA Kit for Human BGnT-5
    CLIA Kit for Human BGnT-5
    CLIA Kit for Human BGnT-5
    CLIA Kit for Human BGnT-5
    Polyclonal Antibody for Human BGnT-5
    Polyclonal Antibody for Human BGnT-5
    Polyclonal Antibody for Human BGnT-5
    Polyclonal Antibody for Human BGnT-5
    Monoclonal Antibody for Human BGnT-5
    Monoclonal Antibody for Human BGnT-5
    Monoclonal Antibody for Human BGnT-5
    Monoclonal Antibody for Human BGnT-5
    Protein for Human BGnT-5
    Protein for Human BGnT-5
    Protein for Human BGnT-5
    Protein for Human BGnT-5

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids."
      Togayachi A. , Akashima T. , Ookubo R. , Kudo T. , Nishihara S. , Iwasaki H. , Natsume A. , Mio H. , Inokuchi J. , Irimura T. , Sasaki K. , Narimatsu H.
      J. Biol. Chem.276:22032-22040(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;TISSUE SPECIFICITY;INDUCTION
    2. 2.
      "Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis."
      Henion T.R. , Zhou D. , Wolfer D.P. , Jungalwala F.B. , Hennet T.
      J. Biol. Chem.276:30261-30269(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      Bennett E.P.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
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