Gene name:
KCTD13 (FKSG86;PP6832;BACURD1;PDIP1;POLDIP1) ;
Protein name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) ;
Alternative:
Polymerase delta-interacting protein 1 ;BTB/POZ domain-containing protein KCTD13 ;TNFAIP1-like protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with POLD2 and PCNA.
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSAEASGPAA | AAAPSLEAPK | PSGLEPGPAA | YGLKPLTPNS | KYVKLNVGGS |
100:
LHYTTLRTLT | GQDTMLKAMF | SGRVEVLTDA | GGWVLIDRSG | RHFGTILNYL |
150:
RDGSVPLPES | TRELGELLGE | ARYYLVQGLI | EDCQLALQQK | RETLSPLCLI |
200:
PMVTSPREEQ | QLLASTSKPV | VKLLHNRSNN | KYSYTSTSDD | NLLKNIELFD |
250:
KLALRFHGRL | LFLKDVLGDE | ICCWSFYGQG | RKIAEVCCTS | IVYATEKKQT |
300:
KVEFPEARIF | EETLNILIYE | TPRGPDPALL | EATGGAAGAG | GAGRGEDEEN |
329:
REHRVRRIHV | RRHITHDERP | HGQQIVFKD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
ELISA Kit for Human hBACURD1
ELISA Kit for Human hBACURD1
ELISA Kit for Human hBACURD1
CLIA Kit for Human hBACURD1
CLIA Kit for Human hBACURD1
CLIA Kit for Human hBACURD1
Polyclonal Antibody for Human hBACURD1
Polyclonal Antibody for Human hBACURD1
Polyclonal Antibody for Human hBACURD1
Monoclonal Antibody for Human hBACURD1
Monoclonal Antibody for Human hBACURD1
Monoclonal Antibody for Human hBACURD1
Protein for Human hBACURD1
Protein for Human hBACURD1
Protein for Human hBACURD1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Brain .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX;INTERACTION WITH RHOA;MUTAGENESIS OF 84-VAL--ILE-86