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Index > Protein center > KCTD13(Gene name) > Human
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  • KCTD13 (Gene name),
  • BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (Protein name ),  BACD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KCTD13(FKSG86;PP6832;BACURD1;PDIP1;POLDIP1);
    Protein name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1(hBACURD1);
    Alternative:
    Polymerase delta-interacting protein 1;BTB/POZ domain-containing protein KCTD13;TNFAIP1-like protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with POLD2 and PCNA.
    Function:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    329
    Sequence:
    50:
    MSAEASGPAA | AAAPSLEAPK | PSGLEPGPAA | YGLKPLTPNS | KYVKLNVGGS | 
    100:
    LHYTTLRTLT | GQDTMLKAMF | SGRVEVLTDA | GGWVLIDRSG | RHFGTILNYL | 
    150:
    RDGSVPLPES | TRELGELLGE | ARYYLVQGLI | EDCQLALQQK | RETLSPLCLI | 
    200:
    PMVTSPREEQ | QLLASTSKPV | VKLLHNRSNN | KYSYTSTSDD | NLLKNIELFD | 
    250:
    KLALRFHGRL | LFLKDVLGDE | ICCWSFYGQG | RKIAEVCCTS | IVYATEKKQT | 
    300:
    KVEFPEARIF | EETLNILIYE | TPRGPDPALL | EATGGAAGAG | GAGRGEDEEN | 
    329:
    REHRVRRIHV | RRHITHDERP | HGQQIVFKD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human hBACURD1
    ELISA Kit for Human hBACURD1
    ELISA Kit for Human hBACURD1
    CLIA Kit for Human hBACURD1
    CLIA Kit for Human hBACURD1
    CLIA Kit for Human hBACURD1
    Polyclonal Antibody for Human hBACURD1
    Polyclonal Antibody for Human hBACURD1
    Polyclonal Antibody for Human hBACURD1
    Monoclonal Antibody for Human hBACURD1
    Monoclonal Antibody for Human hBACURD1
    Monoclonal Antibody for Human hBACURD1
    Protein for Human hBACURD1
    Protein for Human hBACURD1
    Protein for Human hBACURD1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen."
      He H. , Tan C.-K. , Downey K.M. , So A.G.
      Proc. Natl. Acad. Sci. U.S.A.98:11979-11984(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INTERACTION WITH PCNA AND POLD2;TISSUE SPECIFICITY;INDUCTION
    2. 2.
      He H. , Tan C.-K. , Downey K.M. , So A.G.
      Submitted (2006-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Cloning and characterization of FKSG86, a novel gene encoding a TNFAIP1-like protein."
      Wang Y.-G. , Gong L.
      Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Amygdala.
    6. 6.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    9. 9.
      "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement."
      Chen Y. , Yang Z. , Meng M. , Zhao Y. , Dong N. , Yan H. , Liu L. , Ding M. , Peng H.B. , Shao F.
      Mol. Cell35:841-855(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX;INTERACTION WITH RHOA;MUTAGENESIS OF 84-VAL--ILE-86
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