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Index > Protein center > TNFAIP1(Gene name) > Human
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  • TNFAIP1 (Gene name),
  • BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (Protein name ),  BACD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFAIP1(BACURD2;EDP1);
    Protein name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2(hBACURD2);
    Alternative:
    Protein B12;BTB/POZ domain-containing protein TNFAIP1;Tumor necrosis factor, alpha-induced protein 1, endothelial;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BCR(BACURD2) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B.
    Function:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
    Subcellular Location:
    Cytoplasm Nucleus Endosome Colocalizes with RHOB in endosomes.
    Protein Attributes:
    Sequence length:
    316
    Sequence:
    50:
    MSGDTCLCPA | SGAKPKLSGF | KGGGLGNKYV | QLNVGGSLYY | TTVRALTRHD | 
    100:
    TMLKAMFSGR | MEVLTDKEGW | ILIDRCGKHF | GTILNYLRDD | TITLPQNRQE | 
    150:
    IKELMAEAKY | YLIQGLVNMC | QSALQDKKDS | YQPVCNIPII | TSLKEEERLI | 
    200:
    ESSTKPVVKL | LYNRSNNKYS | YTSNSDDHLL | KNIELFDKLS | LRFNGRVLFI | 
    250:
    KDVIGDEICC | WSFYGQGRKL | AEVCCTSIVY | ATEKKQTKVE | FPEARIYEET | 
    300:
    LNVLLYETPR | VPDNSLLEAT | SRSRSQASPS | EDEETFELRD | RVRRIHVKRY | 
    316:
    STYDDRQLGH | QSTHRD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human hBACURD2
    ELISA Kit for Human hBACURD2
    ELISA Kit for Human hBACURD2
    ELISA Kit for Human hBACURD2
    CLIA Kit for Human hBACURD2
    CLIA Kit for Human hBACURD2
    CLIA Kit for Human hBACURD2
    CLIA Kit for Human hBACURD2
    Polyclonal Antibody for Human hBACURD2
    Polyclonal Antibody for Human hBACURD2
    Polyclonal Antibody for Human hBACURD2
    Polyclonal Antibody for Human hBACURD2
    Monoclonal Antibody for Human hBACURD2
    Monoclonal Antibody for Human hBACURD2
    Monoclonal Antibody for Human hBACURD2
    Monoclonal Antibody for Human hBACURD2
    Protein for Human hBACURD2
    Protein for Human hBACURD2
    Protein for Human hBACURD2
    Protein for Human hBACURD2

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    Precision
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    Linearity
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    References
    1. 1.
      "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene."
      Wolf F.W. , Marks R.M. , Sarma V. , Byers M.G. , Katz R.W. , Shows T.B. , Dixit V.M.
      J. Biol. Chem.267:1317-1326(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Endothelial cell.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Amygdala.
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278 AND SER-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells."
      Kim D.M. , Chung K.S. , Choi S.J. , Jung Y.J. , Park S.K. , Han G.H. , Ha J.S. , Song K.B. , Choi N.S. , Kim H.M. , Won M. , Seo Y.S.
      Int. J. Cancer125:2520-2527(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RHOB
    10. 11.
      "CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA."
      Yang L. , Liu N. , Hu X. , Zhang W. , Wang T. , Li H. , Zhang B. , Xiang S. , Zhou J. , Zhang J.
      Mol. Biol. Rep.37:2967-2973(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK2B AND PCNA;PHOSPHORYLATION AT SER-280;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-142; THR-237; SER-265; SER-278 AND SER-280
    11. 12.
      "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement."
      Chen Y. , Yang Z. , Meng M. , Zhao Y. , Dong N. , Yan H. , Liu L. , Ding M. , Peng H.B. , Shao F.
      Mol. Cell35:841-855(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX;INTERACTION WITH RHOA;MUTAGENESIS OF 71-ILE--ILE-73
    12. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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