Gene name:
TNFAIP1 (BACURD2;EDP1) ;
Protein name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) ;
Alternative:
Protein B12 ;BTB/POZ domain-containing protein TNFAIP1 ;Tumor necrosis factor, alpha-induced protein 1, endothelial ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the BCR(BACURD2) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B.
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Subcellular Location:
Cytoplasm
Nucleus
Endosome
Colocalizes with RHOB in endosomes.
Protein Attributes:
50:
MSGDTCLCPA | SGAKPKLSGF | KGGGLGNKYV | QLNVGGSLYY | TTVRALTRHD |
100:
TMLKAMFSGR | MEVLTDKEGW | ILIDRCGKHF | GTILNYLRDD | TITLPQNRQE |
150:
IKELMAEAKY | YLIQGLVNMC | QSALQDKKDS | YQPVCNIPII | TSLKEEERLI |
200:
ESSTKPVVKL | LYNRSNNKYS | YTSNSDDHLL | KNIELFDKLS | LRFNGRVLFI |
250:
KDVIGDEICC | WSFYGQGRKL | AEVCCTSIVY | ATEKKQTKVE | FPEARIYEET |
300:
LNVLLYETPR | VPDNSLLEAT | SRSRSQASPS | EDEETFELRD | RVRRIHVKRY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Rat
Human
ELISA Kit for Human hBACURD2
ELISA Kit for Human hBACURD2
ELISA Kit for Human hBACURD2
ELISA Kit for Human hBACURD2
CLIA Kit for Human hBACURD2
CLIA Kit for Human hBACURD2
CLIA Kit for Human hBACURD2
CLIA Kit for Human hBACURD2
Polyclonal Antibody for Human hBACURD2
Polyclonal Antibody for Human hBACURD2
Polyclonal Antibody for Human hBACURD2
Polyclonal Antibody for Human hBACURD2
Monoclonal Antibody for Human hBACURD2
Monoclonal Antibody for Human hBACURD2
Monoclonal Antibody for Human hBACURD2
Monoclonal Antibody for Human hBACURD2
Protein for Human hBACURD2
Protein for Human hBACURD2
Protein for Human hBACURD2
Protein for Human hBACURD2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CSNK2B AND PCNA;PHOSPHORYLATION AT SER-280;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-142; THR-237; SER-265; SER-278 AND SER-280
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Sci. Signal.3:RA3-RA3(2010)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .