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Index > Protein center > Tnfaip1(Gene name) > Mouse
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  • Tnfaip1 (Gene name),
  • BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (Protein name ),  BACD2_MOUSE from NCBI database.
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  • Gene name:
    Tnfaip1(Edp1);
    Protein name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2;
    Alternative:
    Tumor necrosis factor, alpha-induced protein 1, endothelial;BTB/POZ domain-containing protein TNFAIP1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the BCR(BACURD2) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B.
    Function:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
    Subcellular Location:
    Cytoplasm Nucleus Endosome Colocalizes with RHOB in endosomes.
    Protein Attributes:
    Sequence length:
    316
    Sequence:
    50:
    MSGDTCLCPA | SGAKPKISGF | KGGGLGNKYV | QLNVGGSLYY | TTVRALTRHD | 
    100:
    TMLKAMFSGR | MEVLTDKEGW | ILIDRCGKHF | GTILNYLRDD | TITLPQSRQE | 
    150:
    IQELMAEAKY | YLIQGLVSTC | QTALQDKKDS | YQPVCNIPII | TSLREEDRLI | 
    200:
    ESSTKPVVKL | LYNRSNNKYS | YTSNSDDHLL | KNIELFDKLS | LRFNGRVLFI | 
    250:
    KDVIGDEICC | WSFYGQGRKL | AEVCCTSIVY | ATEKKQTKVE | FPEARIYEET | 
    300:
    LNVLLYETPR | VPDNSLLEAT | SRSRSQASPS | EDEDTFELRD | RVRRIHVKRY | 
    316:
    STYDDRQLGH | QSTHRD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    ELISA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    ELISA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    ELISA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    CLIA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    CLIA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    CLIA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    CLIA Kit for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Polyclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Polyclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Polyclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Polyclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Monoclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Monoclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Monoclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Monoclonal Antibody for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Protein for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Protein for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Protein for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Protein for Mouse BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse."
      Swift S. , Blackburn C. , Morahan G. , Ashworth A.
      Biochim. Biophys. Acta1442:394-398(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Amnion.
      tissue: Diencephalon.
      tissue: Lung.
      tissue: Thymus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
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