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Index > Protein center > ACOT7(Gene name) > Human
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  • ACOT7 (Gene name),
  • Cytosolic acyl coenzyme A thioester hydrolase (Protein name ),  BACH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ACOT7(BACH);
    Protein name:
    Cytosolic acyl coenzyme A thioester hydrolase;
    Alternative:
    Brain acyl-CoA hydrolase(BACH);Acyl-CoA thioesterase 7;Long chain acyl-CoA thioester hydrolase;CTE-IIa(CTE-II);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homohexamer.
    Function:
    Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
    Subcellular Location:
    Isoform 5 Mitochondrion
    Protein Attributes:
    Sequence length:
    380
    Sequence:
    50:
    MKLLARALRL | CEFGRQASSR | RLVAGQGCVG | PRRGCCAPVQ | VVGPRADLPP | 
    100:
    CGACITGRIM | RPDDANVAGN | VHGGTILKMI | EEAGAIISTR | HCNSQNGERC | 
    150:
    VAALARVERT | DFLSPMCIGE | VAHVSAEITY | TSKHSVEVQV | NVMSENILTG | 
    200:
    AKKLTNKATL | WYVPLSLKNV | DKVLEVPPVV | YSRQEQEEEG | RKRYEAQKLE | 
    250:
    RMETKWRNGD | IVQPVLNPEP | NTVSYSQSSL | IHLVGPSDCT | LHGFVHGGVT | 
    300:
    MKLMDEVAGI | VAARHCKTNI | VTASVDAINF | HDKIRKGCVI | TISGRMTFTS | 
    350:
    NKSMEIEVLV | DADPVVDSSQ | KRYRAASAFF | TYVSLSQEGR | SLPVPQLVPE | 
    380:
    TEDEKKRFEE | GKGRYLQMKA | KRQGHAEPQP | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    E14518m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    U14518r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Cat.:
    P14518Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Monoclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Monoclonal Antibody for Human Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Human Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Human Cytosolic acyl coenzyme A thioester hydrolase
    Protein for Human Cytosolic acyl coenzyme A thioester hydrolase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase."
      Yamada J. , Kurata A. , Hirata M. , Taniguchi T. , Takama H. , Furihata T. , Shiratori K. , Iida N. , Takagi-Sakuma M. , Watanabe T. , Kurosaki K. , Endo T. , Suga T.
      J. Biochem.126:1013-1019(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);CHARACTERIZATION
      tissue: Brain.
    2. 2.
      "Human brain acyl-CoA hydrolase isoforms encoded by a single gene."
      Yamada J. , Kuramochi Y. , Takagi M. , Watanabe T. , Suga T.
      Biochem. Biophys. Res. Commun.299:49-56(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 5 AND 6);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Brain.
    3. 3.
      Hajra A.K. , Uhler M.D. , Larkins L.K.
      Submitted (1997-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
      tissue: Hippocampus.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 5; 6 AND 7)
      tissue: Cerebellum.
      tissue: Colon.
      tissue: Placenta.
      tissue: Stomach.
      tissue: Subthalamic nucleus.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Brain.
    9. 9.
      Lubec G. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 79-90;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Fetal brain.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-168; LYS-198 AND LYS-283;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Human acyl-CoA thioesterase 7."
      Structural genomics consortium (SGC)
      Submitted (2007-08) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 209-378
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