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Index > Protein center > BAG4(Gene name) > Human
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  • BAG4 (Gene name),
  • BAG family molecular chaperone regulator 4 (Protein name ),  BAG4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    BAG4(SODD);
    Protein name:
    BAG family molecular chaperone regulator 4(BAG-4);
    Alternative:
    Silencer of death domains;Bcl-2-associated athanogene 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12.
    Function:
    Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    457
    Sequence:
    50:
    MSALRRSGYG | PSDGPSYGRY | YGPGGGDVPV | HPPPPLYPLR | PEPPQPPISW | 
    100:
    RVRGGGPAET | TWLGEGGGGD | GYYPSGGAWP | EPGRAGGSHQ | EQPPYPSYNS | 
    150:
    NYWNSTARSR | APYPSTYPVR | PELQGQSLNS | YTNGAYGPTY | PPGPGANTAS | 
    200:
    YSGAYYAPGY | TQTSYSTEVP | STYRSSGNSP | TPVSRWIYPQ | QDCQTEAPPL | 
    250:
    RGQVPGYPPS | QNPGMTLPHY | PYGDGNRSVP | QSGPTVRPQE | DAWASPGAYG | 
    300:
    MGGRYPWPSS | APSAPPGNLY | MTESTSPWPS | SGSPQSPPSP | PVQQPKDSSY | 
    350:
    PYSQSDQSMN | RHNFPCSVHQ | YESSGTVNND | DSDLLDSQVQ | YSAEPQLYGN | 
    400:
    ATSDHPNNQD | QSSSLPEECV | PSDESTPPSI | KKIIHVLEKV | QYLEQEVEEF | 
    450:
    VGKKTDKAYW | LLEEMLTKEL | LELDSVETGG | QDSVRQARKE | AVCKIQAILE | 
    457:
    KLEKKGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human BAG-4
    ELISA Kit for Human BAG-4
    CLIA Kit for Human BAG-4
    CLIA Kit for Human BAG-4
    Polyclonal Antibody for Human BAG-4
    Polyclonal Antibody for Human BAG-4
    Monoclonal Antibody for Human BAG-4
    Monoclonal Antibody for Human BAG-4
    Protein for Human BAG-4
    Protein for Human BAG-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
      Takayama S. , Xie Z. , Reed J.C.
      J. Biol. Chem.274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Leukemic T-cell.
    2. 2.
      "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."
      Jiang Y. , Woronicz J.D. , Liu W. , Goeddel D.V.
      Science283:543-546(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH TNFRSF1A AND TNFRSF12
      tissue: Leukemic T-cell.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Trachea.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 7.
      "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."
      Hasson S.A. , Kane L.A. , Yamano K. , Huang C.H. , Sliter D.A. , Buehler E. , Wang C. , Heman-Ackah S.M. , Hessa T. , Guha R. , Martin S.E. , Youle R.J.
      Nature504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PARK2
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 376-457;INTERACTION WITH HSP70;MUTAGENESIS OF GLU-414; ASP-424; 438-ARG-LYS-439 AND GLN-446
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