Bromo adjacent homology domain-containing 1 protein (Protein name
), BAHD1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
BAHD1(KIAA0945);
Protein name:
Bromo adjacent homology domain-containing 1 protein(BAH domain-containing protein 1);
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CBX5 (HP1 alpha), HDAC5, MBD1 and SP1. Forms a transcription silencing complex with at least CBX3 (HP1 gamma), HDAC1, HDAC2 and TRIM28. Interacts with L.monocytogenes LntA; this interaction, occurring at a late Listeria infection stage, relieves transcription repression, mostly that of interferon-stimulated genes.
Function:
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IL28A, IL28B and IL29.
Subcellular Location:
Nucleus
Chromosome
Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27'.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT LYS-298
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS HIS-182 AND LYS-298
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-780 (ISOFORM 3);VARIANT LYS-298
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;DOMAIN BAH;INTERACTION WITH CBX5; HDAC5; MBD1 AND SP1
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-121 AND SER-184;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND SER-184;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN LISTERIA INFECTION;INTERACTION WITH LNTA;IDENTIFICATION IN A COMPLEX WITH CBX3; HDAC1; HDAC2 AND TRIM28
Vaild Sequence:
