BAIAP2 ELISA Kit for Human(Homo sapiens) | EIAab.comBAIAP2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BAIAP2(Gene name) > Human

BAIAP2 (Gene name),

Brain-specific angiogenesis inhibitor 1-associated protein 2 (Protein name ), BAIP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BAIAP2;

Protein name:

Brain-specific angiogenesis inhibitor 1-associated protein 2(BAI-associated protein 2;BAI1-associated protein 2;Protein BAP2);

Alternative:

Insulin receptor substrate p53/p58(IRS-58;IRSp53/58);Fas ligand-associated factor 3(FLAF3);Insulin receptor substrate protein of 53 kDa(IRSp53;Insulin receptor substrate p53);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli EspF-like protein encoded on prophage U (via PXXP motifs).

Function:

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Cell projection filopodium Cell projection ruffle Cytoplasm cytoskeleton Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Protein Attributes:

Sequence length:

552

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

552:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

605475

KEGG:

hsa:10458

SMR:

Q9UQB8

STRING:

9606.ENSP00000316338

UniGene:

Hs.128316

Pfam:

PF08397

String:

Q9UQB8

Uniprot:

Q9UQB8

FOR

ELISA Kit for Human BAI-associated protein 2

CLIA Kit for Human BAI-associated protein 2

Polyclonal Antibody for Human BAI-associated protein 2

Monoclonal Antibody for Human BAI-associated protein 2

Protein for Human BAI-associated protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1."
Oda K. , Shiratsuchi T. , Nishimori H. , Inazawa J. , Yoshikawa H. , Taketani Y. , Nakamura Y. , Tokino T.
Cytogenet. Cell Genet.84:75-82(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5);INTERACTION WITH BAI1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Fetal brain.
2.

"Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate."
Okamura-Oho Y. , Miyashita T. , Ohmi K. , Yamada M.
Hum. Mol. Genet.8:947-957(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4);PHOSPHORYLATION AT TYROSINE RESIDUES;SUBCELLULAR LOCATION;INTERACTION WITH ATN1;TISSUE SPECIFICITY
tissue: Fetal brain.
3.

"Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein."
Miyahara A. , Okumura-Oho Y. , Miyashita T. , Hoshika A. , Yamada M.
J. Hum. Genet.48:410-414(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 4 AND 5)
4.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
tissue: Brain.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6)
tissue: Brain.
tissue: Duodenum.
6.

"A Fas-ligand associated factor 3, FLAF3, potentiates Fas-ligand stability."
Hachiya T. , Kobayasi A. , Touji S. , Tamai K.
Submitted (1996-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-328
tissue: Placenta.
7.

"IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."
Miki H. , Yamaguchi H. , Suetsugu S. , Takenawa T.
Nature408:732-735(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAC1; CDC42; WASF1 AND WASF2
8.

"Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex."
Krugmann S. , Jordens I. , Gevaert K. , Driessens M. , Vandekerckhove J. , Hall A.
Curr. Biol.11:1645-1655(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDC42 AND ENAH;MUTAGENESIS OF PHE-427 AND PRO-428
9.

"Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin."
Govind S. , Kozma R. , Monfries C. , Lim L. , Ahmed S.
J. Cell Biol.152:579-594(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC42;MUTAGENESIS OF ILE-267;TISSUE SPECIFICITY
10.

"The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
Soltau M. , Richter D. , Kreienkamp H.-J.
Mol. Cell. Neurosci.21:575-583(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHANK1; SHANK2; SHANK3 AND CDC42;SUBCELLULAR LOCATION
11.

"IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness."
Funato Y. , Terabayashi T. , Suenaga N. , Seiki M. , Takenawa T. , Miki H.
Cancer Res.64:5237-5244(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPS8;SUBCELLULAR LOCATION
12.

"A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein."
Yamagishi A. , Masuda M. , Ohki T. , Onishi H. , Mochizuki N.
J. Biol. Chem.279:14929-14936(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;FUNCTION
13.

"Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
Disanza A. , Mantoani S. , Hertzog M. , Gerboth S. , Frittoli E. , Steffen A. , Berhoerster K. , Kreienkamp H.J. , Milanesi F. , Di Fiore P.P. , Ciliberto A. , Stradal T.E. , Scita G.
Nat. Cell Biol.8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPS8;MUTAGENESIS OF TRP-413
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-296; SER-323; SER-325; SER-346 AND SER-366;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation."
Weiss S.M. , Ladwein M. , Schmidt D. , Ehinger J. , Lommel S. , Stading K. , Beutling U. , Disanza A. , Frank R. , Jansch L. , Scita G. , Gunzer F. , Rottner K. , Stradal T.E.
Cell Host Microbe5:244-258(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH E.COLI EFFECTOR PROTEIN ESPF(U) AND WITH E.COLI INTIMIN RECEPTOR TIR
17.

"Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation."
Vingadassalom D. , Kazlauskas A. , Skehan B. , Cheng H.C. , Magoun L. , Robbins D. , Rosen M.K. , Saksela K. , Leong J.M.
Proc. Natl. Acad. Sci. U.S.A.106:6754-6759(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH E.COLI EFFECTOR PROTEIN ESPF(U);SUBCELLULAR LOCATION
18.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-340;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53."
Millard T.H. , Bompard G. , Heung M.Y. , Dafforn T.R. , Scott D.J. , Machesky L.M. , Fuetterer K.
EMBO J.24:240-250(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-250;MUTAGENESIS OF LYS-142; LYS-143; LYS-146 AND LYS-147
22.

"Crystal structure of RCB domain of IRSP53."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 1-228

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