Gene name:
ATG14 (KIAA0831) ;
Protein name:
Beclin 1-associated autophagy-related key regulator (Barkor) ;
Alternative:
Autophagy-related protein 14-like protein (Atg14L) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy (By similarity). Interacts with PIK3CB.
Function:
Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.
Subcellular Location:
Cytoplasm
Endoplasmic reticulum
Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes.
Protein Attributes:
50:
MASPSGKGAR | ALEAPGCGPR | PLARDLVDSV | DDAEGLYVAV | ERCPLCNTTR |
100:
RRLTCAKCVQ | SGDFVYFDGR | DRERFIDKKE | RLSRLKSKQE | EFQKEVLKAM |
150:
EGKWITDQLR | WKIMSCKMRI | EQLKQTICKG | NEEMEKNSEG | LLKTKEKNQK |
200:
LYSRAQRHQE | KKEKIQRHNR | KLGDLVEKKT | IDLRSHYERL | ANLRRSHILE |
250:
LTSVIFPIEE | VKTGVRDPAD | VSSESDSAMT | SSTVSKLAEA | RRTTYLSGRW |
300:
VCDDHNGDTS | ISITGPWISL | PNNGDYSAYY | SWVEEKKTTQ | GPDMEQSNPA |
350:
YTISAALCYA | TQLVNILSHI | LDVNLPKKLC | NSEFCGENLS | KQKFTRAVKK |
400:
LNANILYLCF | SQHVNLDQLQ | PLHTLRNLMY | LVSPSSEHLG | RSGPFEVRAD |
450:
LEESMEFVDP | GVAGESDESG | DERVSDEETD | LGTDWENLPS | PRFCDIPSQS |
492:
VEVSQSQSTQ | ASPPIASSSA | GGMISSAAAS | VTSWFKAYTG | HR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human Barkor
ELISA Kit for Human Barkor
ELISA Kit for Human Barkor
CLIA Kit for Human Barkor
CLIA Kit for Human Barkor
CLIA Kit for Human Barkor
Polyclonal Antibody for Human Barkor
Polyclonal Antibody for Human Barkor
Polyclonal Antibody for Human Barkor
Monoclonal Antibody for Human Barkor
Monoclonal Antibody for Human Barkor
Monoclonal Antibody for Human Barkor
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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