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Index > Protein center > ATG14(Gene name) > Human
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  • ATG14 (Gene name),
  • Beclin 1-associated autophagy-related key regulator (Protein name ),  BAKOR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATG14(KIAA0831);
    Protein name:
    Beclin 1-associated autophagy-related key regulator(Barkor);
    Alternative:
    Autophagy-related protein 14-like protein(Atg14L);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy (By similarity). Interacts with PIK3CB.
    Function:
    Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner.
    Subcellular Location:
    Cytoplasm Endoplasmic reticulum Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes.
    Protein Attributes:
    Sequence length:
    492
    Sequence:
    50:
    MASPSGKGAR | ALEAPGCGPR | PLARDLVDSV | DDAEGLYVAV | ERCPLCNTTR | 
    100:
    RRLTCAKCVQ | SGDFVYFDGR | DRERFIDKKE | RLSRLKSKQE | EFQKEVLKAM | 
    150:
    EGKWITDQLR | WKIMSCKMRI | EQLKQTICKG | NEEMEKNSEG | LLKTKEKNQK | 
    200:
    LYSRAQRHQE | KKEKIQRHNR | KLGDLVEKKT | IDLRSHYERL | ANLRRSHILE | 
    250:
    LTSVIFPIEE | VKTGVRDPAD | VSSESDSAMT | SSTVSKLAEA | RRTTYLSGRW | 
    300:
    VCDDHNGDTS | ISITGPWISL | PNNGDYSAYY | SWVEEKKTTQ | GPDMEQSNPA | 
    350:
    YTISAALCYA | TQLVNILSHI | LDVNLPKKLC | NSEFCGENLS | KQKFTRAVKK | 
    400:
    LNANILYLCF | SQHVNLDQLQ | PLHTLRNLMY | LVSPSSEHLG | RSGPFEVRAD | 
    450:
    LEESMEFVDP | GVAGESDESG | DERVSDEETD | LGTDWENLPS | PRFCDIPSQS | 
    492:
    VEVSQSQSTQ | ASPPIASSSA | GGMISSAAAS | VTSWFKAYTG | HR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    MIM:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Barkor
    ELISA Kit for Human Barkor
    ELISA Kit for Human Barkor
    CLIA Kit for Human Barkor
    CLIA Kit for Human Barkor
    CLIA Kit for Human Barkor
    Polyclonal Antibody for Human Barkor
    Polyclonal Antibody for Human Barkor
    Polyclonal Antibody for Human Barkor
    Monoclonal Antibody for Human Barkor
    Monoclonal Antibody for Human Barkor
    Monoclonal Antibody for Human Barkor
    Protein for Human Barkor
    Protein for Human Barkor
    Protein for Human Barkor

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    Precision
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    Recovery
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    Linearity
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    References
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hippocampus.
      tissue: Trachea.
    3. 3.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
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    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG."
      Itakura E. , Kishi C. , Inoue K. , Mizushima N.
      Mol. Biol. Cell19:5360-5372(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;FUNCTION;INTERACTION WITH BECN1; PIK3C3 AND PIK3R4;SUBCELLULAR LOCATION
    7. 7.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."
      Sun Q. , Fan W. , Chen K. , Ding X. , Chen S. , Zhong Q.
      Proc. Natl. Acad. Sci. U.S.A.105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BECN1;SUBCELLULAR LOCATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-416 AND THR-429;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."
      Matsunaga K. , Saitoh T. , Tabata K. , Omori H. , Satoh T. , Kurotori N. , Maejima I. , Shirahama-Noda K. , Ichimura T. , Isobe T. , Akira S. , Noda T. , Yoshimori T.
      Nat. Cell Biol.11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BECN1; PIK3C3 AND PIK3R4;SUBCELLULAR LOCATION
    11. 11.
      "Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L."
      Matsunaga K. , Morita E. , Saitoh T. , Akira S. , Ktistakis N.T. , Izumi T. , Noda T. , Yoshimori T.
      J. Cell Biol.190:511-521(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DOMAIN;MUTAGENESIS OF CYS-43; CYS-46; CYS-55 AND CYS-58
    12. 12.
      "Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG."
      Li X. , He L. , Che K.H. , Funderburk S.F. , Pan L. , Pan N. , Zhang M. , Yue Z. , Zhao Y.
      Nat. Commun.3:662-662(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BECN1;SUBCELLULAR LOCATION
    13. 13.
      "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
      He C. , Wei Y. , Sun K. , Li B. , Dong X. , Zou Z. , Liu Y. , Kinch L.N. , Khan S. , Sinha S. , Xavier R.J. , Grishin N.V. , Xiao G. , Eskelinen E.L. , Scherer P.E. , Whistler J.L. , Levine B.
      Cell154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BECN1P1/BECN2
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