Batf ELISA Kit for Mouse(Mus musculus) | EIAab.comBatf ELISA Kit for Mouse(Mus musculus)

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Batf (Gene name),

Basic leucine zipper transcriptional factor ATF-like (Protein name ), BATF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Batf;

Protein name:

Basic leucine zipper transcriptional factor ATF-like;

Alternative:

B-cell-activating transcription factor(B-ATF);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms heterodimers with JUN, JUNB and JUND. Also interacts with IFI35.

Function:

Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP-responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), but are transcriptionally inert.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

125

Sequence:

50:

100:

125:

PSPPEVVYSA | HAFHQPHISS | PRFQP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.6672

Pfam:

PF00170

String:

O35284

KEGG:

mmu:53314

SMR:

O35284

Uniprot:

O35284

FOR

ELISA Kit for Mouse Basic leucine zipper transcriptional factor ATF-like

CLIA Kit for Mouse Basic leucine zipper transcriptional factor ATF-like

Polyclonal Antibody for Mouse Basic leucine zipper transcriptional factor ATF-like

Monoclonal Antibody for Mouse Basic leucine zipper transcriptional factor ATF-like

Protein for Mouse Basic leucine zipper transcriptional factor ATF-like

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus."
Williams K.L. , Nanda I. , Lyons G.E. , Kuo C.T. , Schmid M. , Leiden J.M. , Kaplan M.H. , Taparowsky E.J.
Eur. J. Immunol.31:1620-1627(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Cecum.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
4.

"Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells."
Senga T. , Iwamoto T. , Humphrey S.E. , Yokota T. , Taparowsky E.J. , Hamaguchi M.
Oncogene21:8186-8191(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY STAT3
5.

"Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation."
Deppmann C.D. , Thornton T.M. , Utama F.E. , Taparowsky E.J.
Biochem. J.374:423-431(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DNA-BINDING;INTERACTION WITH JUNB;PHOSPHORYLATION AT SER-43 AND THR-48;MUTAGENESIS OF SER-43 AND THR-48
6.

"BATF transgenic mice reveal a role for activator protein-1 in NKT cell development."
Williams K.L. , Zullo A.J. , Kaplan M.H. , Brutkiewicz R.R. , Deppmann C.D. , Vinson C. , Taparowsky E.J.
J. Immunol.170:2417-2426(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"The AP-1 transcription factor Batf controls T(H)17 differentiation."
Schraml B.U. , Hildner K. , Ise W. , Lee W.L. , Smith W.A. , Solomon B. , Sahota G. , Sim J. , Mukasa R. , Cemerski S. , Hatton R.D. , Stormo G.D. , Weaver C.T. , Russell J.H. , Murphy T.L. , Murphy K.M.
Nature460:405-409(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE;INTERACTION WITH JUNB
8.

"Batf coordinates multiple aspects of B and T cell function required for normal antibody responses."
Betz B.C. , Jordan-Williams K.L. , Wang C. , Kang S.G. , Liao J. , Logan M.R. , Kim C.H. , Taparowsky E.J.
J. Exp. Med.207:933-942(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
9.

"The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells."
Ise W. , Kohyama M. , Schraml B.U. , Zhang T. , Schwer B. , Basu U. , Alt F.W. , Tang J. , Oltz E.M. , Murphy T.L. , Murphy K.M.
Nat. Immunol.12:536-543(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;DISRUPTION PHENOTYPE
10.

"Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells."
Rutz S. , Noubade R. , Eidenschenk C. , Ota N. , Zeng W. , Zheng Y. , Hackney J. , Ding J. , Singh H. , Ouyang W.
Nat. Immunol.12:1238-1245(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression."
Kuroda S. , Yamazaki M. , Abe M. , Sakimura K. , Takayanagi H. , Iwai Y.
Proc. Natl. Acad. Sci. U.S.A.108:14885-14889(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;INDUCTION
12.

"A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage."
Wang J. , Sun Q. , Morita Y. , Jiang H. , Gross A. , Lechel A. , Hildner K. , Guachalla L.M. , Gompf A. , Hartmann D. , Schambach A. , Wuestefeld T. , Dauch D. , Schrezenmeier H. , Hofmann W.K. , Nakauchi H. , Ju Z. , Kestler H.A. , more...
Cell148:1001-1014(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY STAT3
13.

"A validated regulatory network for Th17 cell specification."
Ciofani M. , Madar A. , Galan C. , Sellars M. , Mace K. , Pauli F. , Agarwal A. , Huang W. , Parkurst C.N. , Muratet M. , Newberry K.M. , Meadows S. , Greenfield A. , Yang Y. , Jain P. , Kirigin F.K. , Birchmeier C. , Wagner E.F. , more...
Cell151:289-303(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function."
Nurieva R.I. , Podd A. , Chen Y. , Alekseev A.M. , Yu M. , Qi X. , Huang H. , Wen R. , Wang J. , Li H.S. , Watowich S.S. , Qi H. , Dong C. , Wang D.
J. Biol. Chem.287:11234-11239(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY STAT5
15.

"Compensatory dendritic cell development mediated by BATF-IRF interactions."
Tussiwand R. , Lee W.L. , Murphy T.L. , Mashayekhi M. , Kc W. , Albring J.C. , Satpathy A.T. , Rotondo J.A. , Edelson B.T. , Kretzer N.M. , Wu X. , Weiss L.A. , Glasmacher E. , Li P. , Liao W. , Behnke M. , Lam S.S. , Aurthur C.T. , more...
Nature490:502-507(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH IRF4; IRF8 AND JUNB;MUTAGENESIS OF HIS-55; LEU-56; LYS-63; 69-ARG-LYS-70 AND GLU-77
16.

"BATF-JUN is critical for IRF4-mediated transcription in T cells."
Li P. , Spolski R. , Liao W. , Wang L. , Murphy T.L. , Murphy K.M. , Leonard W.J.
Nature490:543-546(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH IRF4 AND JUNB
17.

"A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes."
Glasmacher E. , Agrawal S. , Chang A.B. , Murphy T.L. , Zeng W. , Vander Lugt B. , Khan A.A. , Ciofani M. , Spooner C. , Rutz S. , Hackney J. , Nurieva R. , Escalante C.R. , Ouyang W. , Littman D.R. , Murphy K.M. , Singh H.
Science338:975-980(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH IRF4 AND JUNB;MUTAGENESIS OF HIS-55 AND GLU-77

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