Bax ELISA Kit for Mouse(Mus musculus) | EIAab.comBax ELISA Kit for Mouse(Mus musculus)

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Bax (Gene name),

Apoptosis regulator BAX (Protein name ), BAX_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Bax;

Protein name:

Apoptosis regulator BAX;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells.

Function:

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.

Subcellular Location:

Isoform Gamma Cytoplasm

Protein Attributes:

Sequence length:

192

Sequence:

50:

100:

150:

192:

WIQDQGGWEG | LLSYFGTPTW | QTVTIFVAGV | LTASLTIWKK | MG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.19904

SMR:

Q07813

KEGG:

mmu:12028

String:

Q07813

Pfam:

PF00452

Uniprot:

Q07813

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ELISA Kit for Mouse Apoptosis regulator BAX

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E1343h

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96T

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ELISA Kit for Mouse Apoptosis regulator BAX

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E1343m

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96T

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ELISA Kit for Mouse Apoptosis regulator BAX

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E1343r

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ELISA Kit for Mouse Apoptosis regulator BAX

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E1343b

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96T

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CLIA Kit for Mouse Apoptosis regulator BAX

Cat.:

U1343r

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96T

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CLIA Kit for Mouse Apoptosis regulator BAX

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U1343m

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Looking for manual.

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96T

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CLIA Kit for Mouse Apoptosis regulator BAX

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U1343h

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96T

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CLIA Kit for Mouse Apoptosis regulator BAX

Cat.:

U1343b

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96T

Polyclonal Antibody for Mouse Apoptosis regulator BAX

Cat.:

P1343Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Apoptosis regulator BAX

Cat.:

P1343Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Apoptosis regulator BAX

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P1343Rb-m

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Polyclonal Antibody for Mouse Apoptosis regulator BAX

Monoclonal Antibody for Mouse Apoptosis regulator BAX

Protein for Mouse Apoptosis regulator BAX

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration"

Ke Wang, Jia Xiao, Bo Peng, et al.

From:Scientific Reports

References

1.

"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death."
Oltvai Z.N. , Milliman C.L. , Korsmeyer S.J.
Cell74:609-619(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH BCL2;FUNCTION
strain: C57BL/6 X DBA/2.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N-3.
tissue: Mammary tumor.
3.

"Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX."
Ku B. , Liang C. , Jung J.U. , Oh B.H.
Cell Res.21:627-641(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 52-82 IN COMPLEX WITH BCL2;FUNCTION;INTERACTION WITH BCL2 AND BCL2L2

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