Bax ELISA Kit for Rat(Rattus norvegicus) | EIAab.comBax ELISA Kit for Rat(Rattus norvegicus)

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Bax (Gene name),

Apoptosis regulator BAX (Protein name ), BAX_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (5)

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Gene name:

Bax;

Protein name:

Apoptosis regulator BAX;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells.

Function:

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Subcellular Location:

Isoform Gamma Cytoplasm

Protein Attributes:

Sequence length:

192

Sequence:

50:

100:

150:

192:

WIQDQGGWDG | LLSYFGTPTW | QTVTIFVAGV | LTASLTIWKK | MG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:24887

String:

Q63690

UniGene:

Rn.10668

SMR:

Q63690

Pfam:

PF00452

Uniprot:

Q63690

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ELISA Kit for Rat Apoptosis regulator BAX

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E1343h

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96T

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ELISA Kit for Rat Apoptosis regulator BAX

Cat.:

E1343m

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96T

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ELISA Kit for Rat Apoptosis regulator BAX

Cat.:

E1343r

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ELISA Kit for Rat Apoptosis regulator BAX

Cat.:

E1343b

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96T

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CLIA Kit for Rat Apoptosis regulator BAX

Cat.:

U1343r

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96T

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CLIA Kit for Rat Apoptosis regulator BAX

Cat.:

U1343m

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Looking for manual.

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Packing:

96T

Range:

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CLIA Kit for Rat Apoptosis regulator BAX

Cat.:

U1343h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Rat Apoptosis regulator BAX

Cat.:

U1343b

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Packing:

96T

Polyclonal Antibody for Rat Apoptosis regulator BAX

Cat.:

P1343Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator BAX

Cat.:

P1343Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator BAX

Cat.:

P1343Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator BAX

Monoclonal Antibody for Rat Apoptosis regulator BAX

Protein for Rat Apoptosis regulator BAX

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis"

R N Abd-Ellatif, I I Hegab, M M Atef, et al.

From:Chemico-Biological Interactions

[2].

"Mechanistic insights into the effects of quercetin and/or GLP-1 analogue liraglutide on high-fat diet/streptozotocin-induced type 2 diabetes in rats"

H H. Gaballah, S S. Zakaria, S E. Mwafy, et al.

From:Biomedicine & Pharmacotherapy

[3].

"Role of Pigment Epithelium-Derived Factor (PEDF) in Arsenic-Induced Cell Apoptosis of Liver and Brain in a Rat Model"

Wei Zhang, Hongqi Feng, Yanhui Gao, Liyan Sun, Jing Wang, Yuanyuan Li, Cheng Wang, Lijun Zhao, Xinxin Hu, Huixin Sun, Yudan Wei, Dianjun Sun

From:Biological Trace Element Research

[4].

"Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: Impact on NOX-1, inflammation and apoptosis"

Reem N. EI-Naga

From:Toxicology and applied pharmacology

[5].

"Vitamin D ameliorates hepatic ischemic/reperfusion injury in rats"

AA Seif , DM Abdelwahed

From:J Physiol Biochem

References

1.

"The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein."
Han J. , Sabbatini P. , Perez D. , Rao L. , Modha D. , White E.
Genes Dev.10:461-477(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of the 3' end of rat bax-alpha and corresponding developmental down-regulation in differentiating primary, cultured oligodendrocytes."
Madison D.L. , Pfeiffer S.E.
Neurosci. Lett.220:183-186(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-192
tissue: Brain.
3.

"Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels."
Tilly J.L. , Tilly K.I. , Kenton M.L. , Johnson A.L.
Endocrinology136:232-241(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-169
strain: Sprague-Dawley.
tissue: Ovary.

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