BAZ2A ELISA Kit for Human(Homo sapiens) | EIAab.comBAZ2A ELISA Kit for Human(Homo sapiens) | EIAab.com

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BAZ2A (Gene name),

Bromodomain adjacent to zinc finger domain protein 2A (Protein name ), BAZ2A_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

BAZ2A(KIAA0314;TIP5);

Protein name:

Bromodomain adjacent to zinc finger domain protein 2A;

Alternative:

hWALp3;Transcription termination factor I-interacting protein 5(TTF-I-interacting protein 5;Tip5);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1; required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A.

Function:

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing.

Subcellular Location:

Nucleus nucleolus Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.

Protein Attributes:

Sequence length:

1905

Sequence:

50:

MEMEANDHFN | FTGLPPAPAA | SGLKPSPSSG | EGLYTNGSPM | NFPQQGKSLN |

100:

GDVNVNGLST | VSHTTTSGIL | NSAPHSSSTS | HLHHPSVAYD | CLWNYSQYPS |

150:

ANPGSNLKDP | PLLSQFSGGQ | YPLNGILGGS | RQPSSPSHNT | NLRAGSQEFW |

200:

ANGTQSPMGL | NFDSQELYDS | FPDQNFEVMP | NGPPSFFTSP | QTSPMLGSSI |

250:

QTFAPSQEVG | SGIHPDEAAE | KEMTSVVAEN | GTGLVGSLEL | EEEQPELKMC |

300:

GYNGSVPSVE | SLHQEVSVLV | PDPTVSCLDD | PSHLPDQLED | TPILSEDSLE |

350:

PFNSLAPEPV | SGGLYGIDDT | ELMGAEDKLP | LEDSPVISAL | DCPSLNNATA |

400:

FSLLADDSQT | STSIFASPTS | PPVLGESVLQ | DNSFDLNNGS | DAEQEEMETQ |

450:

SSDFPPSLTQ | PAPDQSSTIQ | LHPATSPAVS | PTTSPAVSLV | VSPAASPEIS |

500:

PEVCPAASTV | VSPAVFSVVS | PASSAVLPAV | SLEVPLTASV | TSPKASPVTS |

550:

PAAAFPTASP | ANKDVSSFLE | TTADVEEITG | EGLTASGSGD | VMRRRIATPE |

600:

EVRLPLQHGW | RREVRIKKGS | HRWQGETWYY | GPCGKRMKQF | PEVIKYLSRN |

650:

VVHSVRREHF | SFSPRMPVGD | FFEERDTPEG | LQWVQLSAEE | IPSRIQAITG |

700:

KRGRPRNTEK | AKTKEVPKVK | RGRGRPPKVK | ITELLNKTDN | RPLKKLEAQE |

750:

TLNEEDKAKI | AKSKKKMRQK | VQRGECQTTI | QGQARNKRKQ | ETKSLKQKEA |

800:

KKKSKAEKEK | GKTKQEKLKE | KVKREKKEKV | KMKEKEEVTK | AKPACKADKT |

850:

LATQRRLEER | QRQQMILEEM | KKPTEDMCLT | DHQPLPDFSR | VPGLTLPSGA |

900:

FSDCLTIVEF | LHSFGKVLGF | DPAKDVPSLG | VLQEGLLCQG | DSLGEVQDLL |

950:

VRLLKAALHD | PGFPSYCQSL | KILGEKVSEI | PLTRDNVSEI | LRCFLMAYGV |

1000:

EPALCDRLRT | QPFQAQPPQQ | KAAVLAFLVH | ELNGSTLIIN | EIDKTLESMS |

1050:

SYRKNKWIVE | GRLRRLKTVL | AKRTGRSEVE | MEGPEECLGR | RRSSRIMEET |

1100:

SGMEEEEEEE | SIAAVPGRRG | RRDGEVDATA | SSIPELERQI | EKLSKRQLFF |

1150:

RKKLLHSSQM | LRAVSLGQDR | YRRRYWVLPY | LAGIFVEGTE | GNLVPEEVIK |

1200:

KETDSLKVAA | HASLNPALFS | MKMELAGSNT | TASSPARARG | RPRKTKPGSM |

1250:

QPRHLKSPVR | GQDSEQPQAQ | LQPEAQLHAP | AQPQPQLQLQ | LQSHKGFLEQ |

1300:

EGSPLSLGQS | QHDLSQSAFL | SWLSQTQSHS | SLLSSSVLTP | DSSPGKLDPA |

1350:

PSQPPEEPEP | DEAESSPDPQ | ALWFNISAQM | PCNAAPTPPP | AVSEDQPTPS |

1400:

PQQLASSKPM | NRPSAANPCS | PVQFSSTPLA | GLAPKRRAGD | PGEMPQSPTG |

1450:

LGQPKRRGRP | PSKFFKQMEQ | RYLTQLTAQP | VPPEMCSGWW | WIRDPEMLDA |

1500:

MLKALHPRGI | REKALHKHLN | KHRDFLQEVC | LRPSADPIFE | PRQLPAFQEG |

1550:

IMSWSPKEKT | YETDLAVLQW | VEELEQRVIM | SDLQIRGWTC | PSPDSTREDL |

1600:

AYCEHLSDSQ | EDITWRGRGR | EGLAPQRKTT | NPLDLAVMRL | AALEQNVERR |

1650:

YLREPLWPTH | EVVLEKALLS | TPNGAPEGTT | TEISYEITPR | IRVWRQTLER |

1700:

CRSAAQVCLC | LGQLERSIAW | EKSVNKVTCL | VCRKGDNDEF | LLLCDGCDRG |

1750:

CHIYCHRPKM | EAVPEGDWFC | TVCLAQQVEG | EFTQKPGFPK | RGQKRKSGYS |

1800:

LNFSEGDGRR | RRVLLRGRES | PAAGPRYSEE | GLSPSKRRRL | SMRNHHSDLT |

1850:

FCEIILMEME | SHDAAWPFLE | PVNPRLVSGY | RRIIKNPMDF | STMRERLLRG |

1900:

GYTSSEEFAA | DALLVFDNCQ | TFNEDDSEVG | KAGHIMRRFF | ESRWEEFYQG |

1905:

KQANL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Pfam:

MIM:

String:

KEGG:

UniGene:

STRING:

9606.ENSP00000368754

Uniprot:

FOR

ELISA Kit for Human Bromodomain adjacent to zinc finger domain protein 2A

ELISA Kit for Human Bromodomain adjacent to zinc finger domain protein 2A

CLIA Kit for Human Bromodomain adjacent to zinc finger domain protein 2A

CLIA Kit for Human Bromodomain adjacent to zinc finger domain protein 2A

Polyclonal Antibody for Human Bromodomain adjacent to zinc finger domain protein 2A

Polyclonal Antibody for Human Bromodomain adjacent to zinc finger domain protein 2A

Monoclonal Antibody for Human Bromodomain adjacent to zinc finger domain protein 2A

Monoclonal Antibody for Human Bromodomain adjacent to zinc finger domain protein 2A

Protein for Human Bromodomain adjacent to zinc finger domain protein 2A

Protein for Human Bromodomain adjacent to zinc finger domain protein 2A

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"A novel family of bromodomain genes."
Jones M.H. , Hamana N. , Nezu J. , Shimane M.
Genomics63:40-45(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Testis.
2.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Fetal kidney.
3.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-1905 (ISOFORM 2)
tissue: Brain.
5.

Ohara O. , Nagase T. , Kikuno R. , Nomura N.
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-1905 (ISOFORMS 1/2)
tissue: Placenta.
7.

Jansa P. , Grummt I.
Submitted (1997-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 359-753
tissue: Lung.
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1905
tissue: Lymph.
9.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1559;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1747; SER-1770 AND SER-1783;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing."
Zhou Y. , Schmitz K.M. , Mayer C. , Yuan X. , Akhtar A. , Grummt I.
Nat. Cell Biol.11:1010-1016(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-680
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1397 AND SER-1783;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509; SER-1397; SER-1770 AND SER-1783;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-509; SER-1397; SER-1783 AND SER-1785;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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