Pik3ap1 ELISA Kit for Mouse(Mus musculus) | EIAab.comPik3ap1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Pik3ap1 (Gene name),

Phosphoinositide 3-kinase adapter protein 1 (Protein name ), BCAP_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Pik3ap1(Bcap);

Protein name:

Phosphoinositide 3-kinase adapter protein 1;

Alternative:

B-cell phosphoinositide 3-kinase adapter protein 1;B-cell adapter for phosphoinositide 3-kinase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Self-associates (Probable). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain). Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1.

Function:

Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation. May be involved in the survival of mature B cells via activation of REL.

Subcellular Location:

Cytoplasm Cell membrane

Protein Attributes:

Sequence length:

811

Sequence:

50:

MAASGWGRGC | DILIFYSPDA | EEWCQYLQDL | FVSCRQVRSQ | KTQTYRLVPD |

100:

ASFSAQDLWV | FRDARCVLVL | LSAGLVGCFG | QPGLLPMLQR | ACHPPQRVVR |

150:

LLCGVQPGDE | DFQAFFPDWA | HWQEMTCDDE | PETYLAAVRK | AISEDSGCDS |

200:

VTDTEPEDER | ELPFSKQTNL | PPEISPGNLM | VVQPDRIRCG | AETTVYIIVR |

250:

CKLDEKVSTE | AEFSPEDSPS | IRVEGTLENE | YTVSVKAPDL | SSGNVSLKVY |

300:

SGDLVVCETT | VSYYTDMEEI | GNLLSSAANP | VEFMCQAFKI | VPYNTETLDK |

350:

LLTESLKNNI | PASGLHLFGI | NQLEEDDMMT | NQRDEELPTL | LHFAAKYGLK |

400:

NLTALLLTCP | GALQAYSVAN | KHGHYPNTIA | EKHGFRDLRQ | FIDEYVETVD |

450:

MLKTHIKEEL | MQGEEADDVY | ESMAHLSTDL | LMKCSLNPGC | DDELYESMAA |

500:

FAPAATEDLY | VEMLQASAGN | PVSGESFSRP | TKDSMIRKFL | EGNSVKPASW |

550:

EREQHHPYGE | ELYHIVDEDE | TFSVDLANRP | PVPVPRPEAS | APGPPPPPDN |

600:

EPYISKVFAE | KSQERLGNFY | VSSESIRKEP | LVRPWRDRPP | SSIYDPFAGM |

650:

KTPGQRQLIT | LQEQVKLGIV | NVDEAVLHFK | EWQLNQKKRS | ESFRFQQENL |

700:

KRLRESITRR | RKEKPKSGKH | TDLEITVPIR | HSQHLPEKVE | FGVYESGPRK |

750:

SVLPARTELR | RGDWKTDSMS | STASSTSNRS | STRSLLSVSS | GMEGDNEDNE |

800:

IPEITRSRGP | GPTQVDGAPV | VTGTPVGTLE | RPPRVPPRAA | SQRPLTRESF |

811:

HPPPPVPPRG | R

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

UniGene:

KEGG:

Pfam:

SMR:

String:

STRING:

10090.ENSMUSP00000112202

Uniprot:

FOR

ELISA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

ELISA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

ELISA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

CLIA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

CLIA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

CLIA Kit for Mouse Phosphoinositide 3-kinase adapter protein 1

Polyclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Polyclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Polyclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Monoclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Monoclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Monoclonal Antibody for Mouse Phosphoinositide 3-kinase adapter protein 1

Protein for Mouse Phosphoinositide 3-kinase adapter protein 1

Protein for Mouse Phosphoinositide 3-kinase adapter protein 1

Protein for Mouse Phosphoinositide 3-kinase adapter protein 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation."
Okada T. , Maeda A. , Iwamatsu A. , Gotoh K. , Kurosaki T.
Immunity13:817-827(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH PIK3R1;PHOSPHORYLATION AT TYR-264; TYR-420; TYR-445 AND TYR-460
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain: C57BL/6J.
strain: NOD.
tissue: Bone marrow.
tissue: Ovary.
tissue: Spleen.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement."
Inabe K. , Kurosaki T.
Blood99:584-589(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TYROSINE PHOSPHORYLATION (ISOFORMS 1 AND 2)
5.

"Essential immunoregulatory role for BCAP in B cell development and function."
Yamazaki T. , Takeda K. , Gotoh K. , Takeshima H. , Akira S. , Kurosaki T.
J. Exp. Med.195:535-545(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
6.

"Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP."
Battersby A. , Csiszar A. , Leptin M. , Wilson R.
J. Mol. Biol.329:479-493(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMOOLIGOMERIZATION;DBB DOMAIN
7.

"Contribution of BCAP to maintenance of mature B cells through c-Rel."
Yamazaki T. , Kurosaki T.
Nat. Immunol.4:780-786(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase."
Aiba Y. , Kameyama M. , Yamazaki T. , Tedder T.F. , Kurosaki T.
Blood111:1497-1503(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIK3R1;PHOSPHORYLATION AT TYR-264; TYR-420; TYR-445 AND TYR-460;MUTAGENESIS OF TYR-264; TYR-420; TYR-445 AND TYR-460;DISRUPTION PHENOTYPE
9.

"Enhanced NK cell development and function in BCAP-deficient mice."
Macfarlane A.W. IV , Yamazaki T. , Fang M. , Sigal L.J. , Kurosaki T. , Campbell K.S.
Blood112:131-140(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
10.

"Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics."
Matsumura T. , Oyama M. , Kozuka-Hata H. , Ishikawa K. , Inoue T. , Muta T. , Semba K. , Inoue J.
Biochem. Biophys. Res. Commun.400:265-270(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING (ISOFORMS 1 AND 2);PHOSPHORYLATION AT TYR-420; TYR-445 AND TYR-460 BY SYK
11.

"B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K."
Ni M. , MacFarlane A.W. IV , Toft M. , Lowell C.A. , Campbell K.S. , Hamerman J.A.
Proc. Natl. Acad. Sci. U.S.A.109:267-272(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING;DISRUPTION PHENOTYPE;PHOSPHORYLATION;SUBCELLULAR LOCATION
12.

"Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt."
Troutman T.D. , Hu W. , Fulenchek S. , Yamazaki T. , Kurosaki T. , Bazan J.F. , Pasare C.
Proc. Natl. Acad. Sci. U.S.A.109:273-278(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TOLL-LIKE RECEPTOR SIGNALING;INTERACTION WITH MYD88 AND TIRAP;PHOSPHORYLATION

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