BCR ELISA Kit for Human(Homo sapiens) | EIAab.comBCR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BCR(Gene name) > Human

BCR (Gene name),

Breakpoint cluster region protein (Protein name ), BCR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

BCR(BCR1;D22S11);

Protein name:

Breakpoint cluster region protein;

Alternative:

Renal carcinoma antigen NY-REN-26;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2.

Function:

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1271

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1271:

QLEAIPAPDS | KRQSILFSTE | V

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P11274

KEGG:

hsa:613

SMR:

P11274

MIM:

151410

UniGene:

Hs.517461

Pfam:

PF09036

STRING:

9606.ENSP00000303507

Uniprot:

P11274

FOR

ELISA Kit for Human Breakpoint cluster region protein

CLIA Kit for Human Breakpoint cluster region protein

Polyclonal Antibody for Human Breakpoint cluster region protein

Monoclonal Antibody for Human Breakpoint cluster region protein

Protein for Human Breakpoint cluster region protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"bcr genes and transcripts."
Lifshitz B. , Fainstein E. , Marcelle C. , Shtivelman E. , Amson R. , Gale R.P. , Canaani E.
Oncogene2:113-117(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT SER-796
2.

"Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation."
Chissoe S.L. , Bodenteich A. , Wang Y.-F. , Wang Y.-P. , Burian D. , Clifton S.W. , Crabtree J. , Freeman A. , Iyer K. , Jian L. , Ma Y. , McLaury H.-J. , Pan H.-Q. , Sarhan O.H. , Toth S. , Wang Z. , Zhang G. , Heisterkamp N. , more...
Genomics27:67-82(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-796
tissue: Brain.
4.

"cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia."
Hariharan I.K. , Adams J.M.
EMBO J.6:115-119(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-872;VARIANT SER-796
5.

"Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome."
Mes-Masson A.-M. , McLaughlin J. , Daley G.Q. , Paskind M. , Witte O.N.
Proc. Natl. Acad. Sci. U.S.A.83:9768-9772(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-693
6.

Mes-Masson A.M. , McLaughlin J. , Daley G.Q. , Paskind M. , Witte O.N.
Proc. Natl. Acad. Sci. U.S.A.84:2507-2507(1987)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
7.

"Structural organization of the bcr gene and its role in the Ph' translocation."
Heisterkamp N. , Stam K. , Groffen J. , de Klein A. , Grosveld G.
Nature315:758-761(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 683-1271 (ISOFORM 1)
8.

"Unique organization of the human BCR gene promoter."
Zhu Q.S. , Heisterkamp N. , Groffen J.
Nucleic Acids Res.18:7119-7125(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46 AND 275-426
9.

"A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia."
Fainstein E. , Marcelle C. , Rosner A. , Canaani E. , Gale R.P. , Dreazen O. , Smith S.D. , Croce C.M.
Nature330:386-388(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-426
10.

"Alternative 5' end of the bcr-abl transcript in chronic myelogenous leukemia."
Romero P. , Beran M. , Shtalrid M. , Andersson B. , Talpaz M. , Blick M.
Oncogene4:93-98(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 362-438;ALTERNATIVE SPLICING
11.

"Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript."
Selleri L. , von Lindern M. , Hermans A. , Meijer D. , Torelli G. , Grosveld G.
Blood75:1146-1153(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 670-842;VARIANT SER-796
12.

"Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines."
Shah N.P. , Witte O.N. , Denny C.T.
Mol. Cell. Biol.11:1854-1860(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4
13.

"Bcr encodes a GTPase-activating protein for p21rac."
Diekmann D. , Brill S. , Garrett M.D. , Totty N. , Hsuan J. , Monfries C. , Hall C. , Lim L. , Hall A.
Nature351:400-402(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner."
Pendergast A.M. , Muller A.J. , Havlik M.H. , Maru Y. , Witte O.N.
Cell66:161-171(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ABL1 SH2-DOMAIN
15.

"The BCR gene encodes a novel serine/threonine kinase activity within a single exon."
Maru Y. , Witte O.N.
Cell67:459-468(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PROTEIN KINASE
16.

"The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr."
Warmuth M. , Bergmann M. , Priess A. , Hauslmann K. , Emmerich B. , Hallek M.
J. Biol. Chem.272:33260-33270(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-177 BY HCK;MUTAGENESIS OF TYR-177;INTERACTION WITH HCK AND GRB2
17.

"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN
tissue: Renal cell carcinoma.
18.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1264;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner."
Laurent C.E. , Smithgall T.E.
Exp. Cell Res.299:188-198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FES/FPS; ABL1; PIK3R1 AND GRB2;MUTAGENESIS OF TYR-177;PHOSPHORYLATION AT TYR-246
20.

"Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3."
Malmberg E.K. , Andersson C.X. , Gentzsch M. , Chen J.H. , Mengos A. , Cui L. , Hansson G.C. , Riordan J.R.
J. Cell Sci.117:5535-5541(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDZK1;MUTAGENESIS OF 1269-THR--GLU-1271 AND VAL-1271
21.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
23.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-459;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-177; SER-459 AND SER-1264;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
25.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-215 AND SER-459;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"Structure of the Bcr-Abl oncoprotein oligomerization domain."
Zhao X. , Ghaffari S. , Lodish H. , Malashkevich V.N. , Kim P.S.
Nat. Struct. Biol.9:117-120(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 3-72;HOMOTETRAMERIZATION
29.

"src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP."
Gray E.J. , Petsalaki E. , James D.A. , Bagshaw R.D. , Stacey M.M. , Rocks O. , Gingras A.C. , Pawson T.
J. Biol. Chem.0:0-0(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2D5
30.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-400; MET-413; GLU-752; SER-796; CYS-910; ILE-949; LYS-1037; MET-1091; ALA-1096; GLY-1104; ASN-1106; THR-1149; LYS-1161; GLU-1187; MET-1189; GLY-1204 AND ARG-1235

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