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Index > Protein center > Arfgef1(Gene name) > Mouse
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  • Arfgef1 (Gene name),
  • Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Protein name ),  BIG1_MOUSE from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    Arfgef1;
    Protein name:
    Brefeldin A-inhibited guanine nucleotide-exchange protein 1(BIG1);
    Alternative:
    ADP-ribosylation factor guanine nucleotide-exchange factor 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with BIG1; both proteins are probably part of the same or very similar macromolecular complexes. Interacts with FKBP2, DPY30, MYO9B, PRKAR1A, PRKAR2A, PPP1CC and PDE3A. Interacts with KANK1; however, colocalization cannot be experimentally confirmed. Interacts with NCL, FBL, NUP62 and U3 small nucleolar RNA.
    Function:
    Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.
    Subcellular Location:
    Cytoplasm Cytoplasm Perinuclear region Golgi apparatus Golgi apparatus Trans-Golgi network Nucleus Nucleus Nucleolus Nucleus matrix Membrane Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
    Protein Attributes:
    Sequence length:
    1846
    Sequence:
    50:
    MYEGKKTKNM | FLTRALEKIL | ADKEVKKAHH | SQLRKACEVA | LEEIKVETEK | 
    100:
    QSPPHGEAKA | GSGTLPPVKS | KTNFIEADKY | FLPFELACQS | KCPRIVSTSL | 
    150:
    DCLQKLIAYG | HLTGRAPDST | TPGKKLIDRI | IETICGCFQG | PQTDEGVQLQ | 
    200:
    IIKALLTAVT | SQHIEIHEGT | VLQAVRTCYN | IYLASKNLIN | QTTAKATLTQ | 
    250:
    MLNVIFARME | NQALQEAKQM | ERERHRQQQH | LLQSPVSHHE | PESPHLRYLP | 
    300:
    PQTVDHINQE | HEGDLEPQTH | DVDKSLQDDT | EPENGSDISS | AENEQTEADQ | 
    350:
    ATAAETLSKN | DILYDGDYEE | KPLDIVQSIV | EEMVNIIVGD | MGEGMAISAS | 
    400:
    TEGNTGTVED | GSDSENIQAN | GIPGTPISVA | YTPSLPDDRL | SVSSNDTQES | 
    450:
    GNSSGPSPGA | KFSHILQKDA | FLVFRSLCKL | SMKPLSDGPP | DPKSHELRSK | 
    500:
    ILSLQLLLSI | LQNAGPVFRT | NEMFINAIKQ | YLCVALSKNG | VSSVPEVFEL | 
    550:
    SLSIFLTLLS | NFKTHLKMQI | EVFFKEIFLY | ILETSTSSFD | HKWMVIQTLT | 
    600:
    RICADAQSVV | DIYVNYDCDL | NAANIFERLV | NDLSKIAQGR | GSQELGMSNV | 
    650:
    QELSLRKKGL | ECLVSILKCM | VEWSKDQYVN | PNSQTTLGQE | KPSEQEISEV | 
    700:
    KHPETINRYG | SLNSLESTSS | SGIGSYSTQM | SGTDNPEQFE | VLKQQKEIIE | 
    750:
    QGIDLFNKKP | KRGIQYLQEQ | GMLGTTPEDI | AQFLHQEERL | DSTQVGEFLG | 
    800:
    DNDKFNKEVM | YAYVDQHDFS | GKDFVSALRL | FLEGFRLPGE | AQKIDRLMEK | 
    850:
    FAARYLECNQ | GQTLFASADT | AYVLAYSIIM | LTTDLHSPQV | KNKMTKEQYI | 
    900:
    KMNRGINDSK | DLPEEYLSAI | YNEIAGKKIS | MKETKELTIP | TKSTKQNVAS | 
    950:
    EKQRRLLYNL | EMEQMAKTAK | ALMEAVSHVQ | APFTSATHLE | HVRPMFKLAW | 
    1000:
    TPFLAAFSVG | LQDCDDTEVA | SLCLEGIRCA | IRIACIFSIQ | LERDAYVQAL | 
    1050:
    ARFTLLTVSS | GITEMKQKNI | DTIKTLITVA | HTDGNYLGNS | WHEILKCISQ | 
    1100:
    LELAQLIGTG | VKPRYISGTV | RGREGSLTGT | KDQAPDEFVG | LGLVGGNVDW | 
    1150:
    KQIASIQESI | GETSSQSVVV | AVDRIFTGST | RLDGNAIVDF | VRWLCAVSMD | 
    1200:
    ELLSTTHPRM | FSLQKIVEIS | YYNMGRIRLQ | WSRIWEVIGD | HFNKVGCNPN | 
    1250:
    EDVAIFAVDS | LRQLSMKFLE | KGELANFRFQ | KDFLRPFEHI | MKRNRSPTIR | 
    1300:
    DMVVRCIAQM | VNSQAANIRS | GWKNIFSVFH | LAASDQDESI | VELAFQTTGH | 
    1350:
    IVTLVFEKHF | PATIDSFQDA | VKCLSEFACN | AAFPDTSMEA | IRLIRHCAKY | 
    1400:
    VSDRPQAFKE | YTSDDMSVAP | EDRVWVRGWF | PILFELSCII | NRCKLDVRTR | 
    1450:
    GLTVMFEIMK | TYGHTYEKHW | WQDLFRIVFR | IFDNMKLPEQ | QTEKAEWMTT | 
    1500:
    TCNHALYAIC | DVFTQYLEVL | SDVLLDDIFA | QLYWCVQQDN | EQLARSGTNC | 
    1550:
    LENVVILNGE | KFTLEIWDKT | CNCTLDIFKT | TIPHALLTWR | PTSGEAEPPS | 
    1600:
    PSAVSEKPLD | AISQKSVDIH | DSIQPRSSDN | RQQAPLVSVS | TVSEEVSKVK | 
    1650:
    STAKFPEQKL | FAALLIKCVV | QLELIQTIDN | IVFFPATSKK | EDAENLAAAQ | 
    1700:
    RDAVDFDVRV | DTQDQGMYRF | LTSQQLFKLL | DCLLESHRFA | KAFNSNNEQR | 
    1750:
    TALWKAGFKG | KSKPNLLKQE | TSSLACGLRI | LFRMYMDESR | VSAWEEVQQR | 
    1800:
    LLNVCREALS | YFLTLTSESH | REAWTNLLLL | FLTKVLKISD | SRFKAHASFY | 
    1846:
    YPLLCEIMQF | DLIPELRAVL | RRFFLRIGIV | FQISQPPEQE | LGINRQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse BIG1
    ELISA Kit for Mouse BIG1
    ELISA Kit for Mouse BIG1
    ELISA Kit for Mouse BIG1
    CLIA Kit for Mouse BIG1
    CLIA Kit for Mouse BIG1
    CLIA Kit for Mouse BIG1
    CLIA Kit for Mouse BIG1
    Polyclonal Antibody for Mouse BIG1
    Polyclonal Antibody for Mouse BIG1
    Polyclonal Antibody for Mouse BIG1
    Polyclonal Antibody for Mouse BIG1
    Monoclonal Antibody for Mouse BIG1
    Monoclonal Antibody for Mouse BIG1
    Monoclonal Antibody for Mouse BIG1
    Monoclonal Antibody for Mouse BIG1
    Protein for Mouse BIG1
    Protein for Mouse BIG1
    Protein for Mouse BIG1
    Protein for Mouse BIG1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1441-1846
      strain: C57BL/6J.
      tissue: Spinal ganglion.
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