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Index > Protein center > BIRC7(Gene name) > Human
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  • BIRC7 (Gene name),
  • Baculoviral IAP repeat-containing protein 7 (Protein name ),  BIRC7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    BIRC7(UNQ5800/PRO19607/PRO21344;KIAP;LIVIN;MLIAP;RNF50);
    Protein name:
    Baculoviral IAP repeat-containing protein 7;
    Alternative:
    Livin;Kidney inhibitor of apoptosis protein(KIAP);RING finger protein 50;Melanoma inhibitor of apoptosis protein(ML-IAP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to caspase-9. Interaction with SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain.
    Function:
    Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
    Subcellular Location:
    Nucleus Cytoplasm Nuclear, and in a filamentous pattern throughout the cytoplasm.
    Protein Attributes:
    Sequence length:
    298
    Sequence:
    50:
    MGPKDSAKCL | HRGPQPSHWA | AGDGPTQERC | GPRSLGSPVL | GLDTCRAWDH | 
    100:
    VDGQILGQLR | PLTEEEEEEG | AGATLSRGPA | FPGMGSEELR | LASFYDWPLT | 
    150:
    AEVPPELLAA | AGFFHTGHQD | KVRCFFCYGG | LQSWKRGDDP | WTEHAKWFPS | 
    200:
    CQFLLRSKGR | DFVHSVQETH | SQLLGSWDPW | EEPEDAAPVA | PSVPASGYPE | 
    250:
    LPTPRREVQS | ESAQEPGGVS | PAEAQRAWWV | LEPPGARDVE | AQLRRLQEER | 
    298:
    TCKVCLDRAV | SIVFVPCGHL | VCAECAPGLQ | LCPICRAPVR | SRVRTFLS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Baculoviral IAP repeat-containing protein 7
    ELISA Kit for Human Baculoviral IAP repeat-containing protein 7
    CLIA Kit for Human Baculoviral IAP repeat-containing protein 7
    CLIA Kit for Human Baculoviral IAP repeat-containing protein 7
    Polyclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
    Polyclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
    Monoclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
    Monoclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
    Protein for Human Baculoviral IAP repeat-containing protein 7
    Protein for Human Baculoviral IAP repeat-containing protein 7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "KIAP, a novel member of the inhibitor of apoptosis protein family."
      Lin J.-H. , Deng G. , Huang Q. , Morser J.
      Biochem. Biophys. Res. Commun.279:820-831(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Fetal kidney.
    2. 2.
      "Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern."
      Ashhab Y. , Alian A. , Polliack A. , Panet A. , Yehuda D.B.
      FEBS Lett.495:56-60(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);TISSUE SPECIFICITY (ISOFORMS 1 AND 2)
      tissue: Melanoma.
    3. 3.
      "Livin, a novel inhibitor of apoptosis protein family member."
      Kasof G.M. , Gomes B.C.
      J. Biol. Chem.276:3238-3246(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Kidney.
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLN-223
      tissue: Skin.
    7. 7.
      "ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas."
      Vucic D. , Stennicke H.R. , Pisabarro M.T. , Salvesen G.S. , Dixit V.M.
      Curr. Biol.10:1359-1366(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 87-GLU--GLU-88; ASP-120; CYS-124 AND ASP-138
    8. 8.
      "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)."
      Vucic D. , Deshayes K. , Ackerly H. , Pisabarro M.T. , Kadkhodayan S. , Fairbrother W.J. , Dixit V.M.
      J. Biol. Chem.277:12275-12279(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAC
    9. 9.
      "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition."
      Sanna M.G. , da Silva Correia J. , Ducrey O. , Lee J. , Nomoto K. , Schrantz N. , Deveraux Q.L. , Ulevitch R.J.
      Mol. Cell. Biol.22:1754-1766(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION OF MAP KINASES
    10. 10.
      "Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway."
      Ma L. , Huang Y. , Song Z. , Feng S. , Tian X. , Du W. , Qiu X. , Heese K. , Wu M.
      Cell Death Differ.13:2079-2088(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE UBIQUITINATION OF DIABLO/SMAC;INTERACTION WITH DIABLO/SMAC
    11. 11.
      "Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin."
      Nachmias B. , Lazar I. , Elmalech M. , Abed-El-Rahaman I. , Asshab Y. , Mandelboim O. , Perlman R. , Ben-Yehuda D.
      Apoptosis12:1129-1142(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC CLEAVAGE
    13. 13.
      "Challenge and promise: roles for Livin in progression and therapy of cancer."
      Wang L. , Zhang Q. , Liu B. , Han M. , Shan B.
      Mol. Cancer Ther.7:3661-3669(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    14. 14.
      "Research progress on Livin protein: an inhibitor of apoptosis."
      Yan B.
      Mol. Cell. Biochem.357:39-45(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    15. 15.
      "Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)."
      Franklin M.C. , Kadkhodayan S. , Ackerly H. , Alexandru D. , Distefano M.D. , Elliott L.O. , Flygare J.A. , Mausisa G. , Okawa D.C. , Ong D. , Vucic D. , Deshayes K. , Fairbrother W.J.
      Biochemistry42:8223-8231(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 63-179 IN COMPLEX WITH PHAGE-AND SMAC-DERIVED PEPTIDES;ZINC-BINDING SITES
    16. 16.
      "Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP."
      Vucic D. , Franklin M.C. , Wallweber H.J. , Das K. , Eckelman B.P. , Shin H. , Elliott L.O. , Kadkhodayan S. , Deshayes K. , Salvesen G.S. , Fairbrother W.J.
      Biochem. J.385:11-20(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) OF 63-159;ZINC-BINDING SITES
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