Gene name:
BIRC7 (UNQ5800/PRO19607/PRO21344;KIAP;LIVIN;MLIAP;RNF50) ;
Protein name:
Baculoviral IAP repeat-containing protein 7 ;
Alternative:
Livin ;Kidney inhibitor of apoptosis protein (KIAP) ;RING finger protein 50 ;Melanoma inhibitor of apoptosis protein (ML-IAP) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to caspase-9. Interaction with SMAC via the BIR domain disrupts binding to caspase-9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with caspase-3 and caspase-7 via its BIR domain.
Function:
Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
Subcellular Location:
Nucleus
Cytoplasm
Nuclear, and in a filamentous pattern throughout the cytoplasm.
Protein Attributes:
50:
MGPKDSAKCL | HRGPQPSHWA | AGDGPTQERC | GPRSLGSPVL | GLDTCRAWDH |
100:
VDGQILGQLR | PLTEEEEEEG | AGATLSRGPA | FPGMGSEELR | LASFYDWPLT |
150:
AEVPPELLAA | AGFFHTGHQD | KVRCFFCYGG | LQSWKRGDDP | WTEHAKWFPS |
200:
CQFLLRSKGR | DFVHSVQETH | SQLLGSWDPW | EEPEDAAPVA | PSVPASGYPE |
250:
LPTPRREVQS | ESAQEPGGVS | PAEAQRAWWV | LEPPGARDVE | AQLRRLQEER |
298:
TCKVCLDRAV | SIVFVPCGHL | VCAECAPGLQ | LCPICRAPVR | SRVRTFLS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Baculoviral IAP repeat-containing protein 7
ELISA Kit for Human Baculoviral IAP repeat-containing protein 7
CLIA Kit for Human Baculoviral IAP repeat-containing protein 7
CLIA Kit for Human Baculoviral IAP repeat-containing protein 7
Polyclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
Polyclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
Monoclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
Monoclonal Antibody for Human Baculoviral IAP repeat-containing protein 7
Protein for Human Baculoviral IAP repeat-containing protein 7
Protein for Human Baculoviral IAP repeat-containing protein 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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