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Index > Protein center > BLOC1S3(Gene name) > Human
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  • BLOC1S3 (Gene name),
  • Biogenesis of lysosome-related organelles complex 1 subunit 3 (Protein name ),  BL1S3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BLOC1S3(BLOS3);
    Protein name:
    Biogenesis of lysosome-related organelles complex 1 subunit 3(BLOC-1 subunit 3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Interacts directly with BLOC1S2.
    Function:
    The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    202
    Sequence:
    50:
    MASQGRRRRP | LRRPETVVPG | EATETDSERS | ASSSEEEELY | LGPSGPTRGR | 
    100:
    PTGLRVAGEA | AETDSEPEPE | PEPTAAPRDL | PPLVVQRESA | EEAWGTEEAP | 
    150:
    APAPARSLLQ | LRLAESQARL | DHDVAAAVSG | VYRRAGRDVA | ALASRLAAAQ | 
    200:
    AAGLAAAHSV | RLARGDLCAL | AERLDIVAGC | RLLPDIRGVP | GTEPEKDPGP | 
    202:
    RA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human BLOC-1 subunit 3
    ELISA Kit for Human BLOC-1 subunit 3
    ELISA Kit for Human BLOC-1 subunit 3
    ELISA Kit for Human BLOC-1 subunit 3
    CLIA Kit for Human BLOC-1 subunit 3
    CLIA Kit for Human BLOC-1 subunit 3
    CLIA Kit for Human BLOC-1 subunit 3
    CLIA Kit for Human BLOC-1 subunit 3
    Polyclonal Antibody for Human BLOC-1 subunit 3
    Polyclonal Antibody for Human BLOC-1 subunit 3
    Polyclonal Antibody for Human BLOC-1 subunit 3
    Polyclonal Antibody for Human BLOC-1 subunit 3
    Monoclonal Antibody for Human BLOC-1 subunit 3
    Monoclonal Antibody for Human BLOC-1 subunit 3
    Monoclonal Antibody for Human BLOC-1 subunit 3
    Monoclonal Antibody for Human BLOC-1 subunit 3
    Protein for Human BLOC-1 subunit 3
    Protein for Human BLOC-1 subunit 3
    Protein for Human BLOC-1 subunit 3
    Protein for Human BLOC-1 subunit 3

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."
      Starcevic M. , Dell'Angelica E.C.
      J. Biol. Chem.279:28393-28401(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE BLOC-1 COMPLEX;INTERACTION WITH BLOC1S2
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Tongue.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Testis.
    4. 4.
      "A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)."
      Morgan N.V. , Pasha S. , Johnson C.A. , Ainsworth J.R. , Eady R.A.J. , Dawood B. , McKeown C. , Trembath R.C. , Wilde J. , Watson S.P. , Maher E.R.
      Am. J. Hum. Genet.78:160-166(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN HPS8
    5. 5.
      "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."
      Setty S.R. , Tenza D. , Truschel S.T. , Chou E. , Sviderskaya E.V. , Theos A.C. , Lamoreux M.L. , Di Pietro S.M. , Starcevic M. , Bennett D.C. , Dell'Angelica E.C. , Raposo G. , Marks M.S.
      Mol. Biol. Cell18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63 AND SER-65;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63 AND SER-65;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    9. 9.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63 AND SER-65;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."
      Lee H.H. , Nemecek D. , Schindler C. , Smith W.J. , Ghirlando R. , Steven A.C. , Bonifacino J.S. , Hurley J.H.
      J. Biol. Chem.287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;COMPOSITION OF THE BLOC-1 COMPLEX
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