Bloc1s4 ELISA Kit for Mouse(Mus musculus) | EIAab.comBloc1s4 ELISA Kit for Mouse(Mus musculus)

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Bloc1s4 (Gene name),

Biogenesis of lysosome-related organelles complex 1 subunit 4 (Protein name ), BL1S4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Bloc1s4(Cno);

Protein name:

Biogenesis of lysosome-related organelles complex 1 subunit 4(BLOC-1 subunit 4);

Alternative:

Protein cappuccino homolog;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (By similarity). Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S5 and BLOC1S6.

Function:

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

215

Sequence:

50:

100:

150:

200:

215:

RTEDHFPGCG | DRPQL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000071840

UniGene:

Mm.46744

KEGG:

mmu:117197

Uniprot:

Q8VED2

FOR

ELISA Kit for Mouse BLOC-1 subunit 4

CLIA Kit for Mouse BLOC-1 subunit 4

Polyclonal Antibody for Mouse BLOC-1 subunit 4

Monoclonal Antibody for Mouse BLOC-1 subunit 4

Protein for Mouse BLOC-1 subunit 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)."
Ciciotte S.L. , Gwynn B. , Moriyama K. , Huizing M. , Gahl W.A. , Bonifacino J.S. , Peters L.L.
Blood101:4402-4407(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];IDENTIFICATION IN THE BLOC-1 COMPLEX;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH BLOC1S5 AND BLOC1S6
strain: C3H/HeJ.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism."
Gwynn B. , Ciciotte S.L. , Hunter S.J. , Washburn L.L. , Smith R.S. , Andersen S.G. , Swank R.T. , Dell'Angelica E.C. , Bonifacino J.S. , Eicher E.M. , Peters L.L.
Blood96:4227-4235(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
4.

"BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes."
Salazar G. , Craige B. , Styers M.L. , Newell-Litwa K.A. , Doucette M.M. , Wainer B.H. , Falcon-Perez J.M. , Dell'Angelica E.C. , Peden A.A. , Werner E. , Faundez V.
Mol. Biol. Cell17:4014-4026(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."
Ghiani C.A. , Starcevic M. , Rodriguez-Fernandez I.A. , Nazarian R. , Cheli V.T. , Chan L.N. , Malvar J.S. , de Vellis J. , Sabatti C. , Dell'Angelica E.C.
Mol. Psychiatry15:204-215(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
Larimore J. , Tornieri K. , Ryder P.V. , Gokhale A. , Zlatic S.A. , Craige B. , Lee J.D. , Talbot K. , Pare J.F. , Smith Y. , Faundez V.
Mol. Biol. Cell22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH THE AP-3 COMPLEX

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