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Index > Protein center > BLOC1S6(Gene name) > Human
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  • BLOC1S6 (Gene name),
  • Biogenesis of lysosome-related organelles complex 1 subunit 6 (Protein name ),  BL1S6_HUMAN from NCBI database.
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  • Gene name:
    BLOC1S6(PA;PLDN);
    Protein name:
    Biogenesis of lysosome-related organelles complex 1 subunit 6(BLOC-1 subunit 6);
    Alternative:
    Pallidin;Pallid protein homolog;Syntaxin 13-interacting protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BLOC1S4 and DTNBP1/BLOC1S7 (By similarity). Homodimer. Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S5, F-actin, SNAP25 isoform 1 and isoform 2, SNAP47 and STX12.
    Function:
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
    Subcellular Location:
    Cytoplasm Endomembrane system Peripheral membrane protein It can exist as a soluble protein as well as a peripheral membrane protein.
    Protein Attributes:
    Sequence length:
    172
    Sequence:
    50:
    MSVPGPSSPD | GALTRPPYCL | EAGEPTPGLS | DTSPDEGLIE | DLTIEDKAVE | 
    100:
    QLAEGLLSHY | LPDLQRSKQA | LQELTQNQVV | LLDTLEQEIS | KFKECHSMLD | 
    150:
    INALFAEAKH | YHAKLVNIRK | EMLMLHEKTS | KLKKRALKLQ | QKRQKEELER | 
    172:
    EQQREKEFER | EKQLTARPAK | RM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human BLOC-1 subunit 6
    ELISA Kit for Human BLOC-1 subunit 6
    ELISA Kit for Human BLOC-1 subunit 6
    ELISA Kit for Human BLOC-1 subunit 6
    CLIA Kit for Human BLOC-1 subunit 6
    CLIA Kit for Human BLOC-1 subunit 6
    CLIA Kit for Human BLOC-1 subunit 6
    CLIA Kit for Human BLOC-1 subunit 6
    Polyclonal Antibody for Human BLOC-1 subunit 6
    Polyclonal Antibody for Human BLOC-1 subunit 6
    Polyclonal Antibody for Human BLOC-1 subunit 6
    Polyclonal Antibody for Human BLOC-1 subunit 6
    Monoclonal Antibody for Human BLOC-1 subunit 6
    Monoclonal Antibody for Human BLOC-1 subunit 6
    Monoclonal Antibody for Human BLOC-1 subunit 6
    Monoclonal Antibody for Human BLOC-1 subunit 6
    Protein for Human BLOC-1 subunit 6
    Protein for Human BLOC-1 subunit 6
    Protein for Human BLOC-1 subunit 6
    Protein for Human BLOC-1 subunit 6

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    References
    1. 1.
      "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency."
      Huang L. , Kuo Y.-M. , Gitschier J.
      Nat. Genet.23:329-332(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    4. 4.
      "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis."
      Falcon-Perez J.M. , Dell'Angelica E.C.
      Pigment Cell Res.15:82-86(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;ALTERNATIVE SPLICING
    5. 5.
      "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles."
      Moriyama K. , Bonifacino J.S.
      Traffic3:666-677(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH STX12 AND BLOC1S5;HOMODIMERIZATION
    6. 6.
      "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules."
      Falcon-Perez J.M. , Starcevic M. , Gautam R. , Dell'Angelica E.C.
      J. Biol. Chem.277:28191-28199(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH BLOC1S5 AND F-ACTIN;HOMODIMERIZATION
    7. 7.
      "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."
      Setty S.R. , Tenza D. , Truschel S.T. , Chou E. , Sviderskaya E.V. , Theos A.C. , Lamoreux M.L. , Di Pietro S.M. , Starcevic M. , Bennett D.C. , Dell'Angelica E.C. , Raposo G. , Marks M.S.
      Mol. Biol. Cell18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;FUNCTION
    8. 8.
      "The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."
      Ghiani C.A. , Starcevic M. , Rodriguez-Fernandez I.A. , Nazarian R. , Cheli V.T. , Chan L.N. , Malvar J.S. , de Vellis J. , Sabatti C. , Dell'Angelica E.C.
      Mol. Psychiatry15:204-215(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;INTERACTION WITH SNAP25; SNAP47 AND STX12
    9. 9.
      "A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9."
      Cullinane A.R. , Curry J.A. , Carmona-Rivera C. , Summers C.G. , Ciccone C. , Cardillo N.D. , Dorward H. , Hess R.A. , White J.G. , Adams D. , Huizing M. , Gahl W.A.
      Am. J. Hum. Genet.88:778-787(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HPS9
    10. 10.
      "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
      Larimore J. , Tornieri K. , Ryder P.V. , Gokhale A. , Zlatic S.A. , Craige B. , Lee J.D. , Talbot K. , Pare J.F. , Smith Y. , Faundez V.
      Mol. Biol. Cell22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH THE AP-3 COMPLEX;INTERACTION WITH BLOC1S5
    11. 11.
      "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."
      Lee H.H. , Nemecek D. , Schindler C. , Smith W.J. , Ghirlando R. , Steven A.C. , Bonifacino J.S. , Hurley J.H.
      J. Biol. Chem.287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX;COMPOSITION OF THE BLOC-1 COMPLEX
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