Gene name:
BLOC1S6 (PA;PLDN) ;
Protein name:
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) ;
Alternative:
Pallidin ;Pallid protein homolog ;Syntaxin 13-interacting protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BLOC1S4 and DTNBP1/BLOC1S7 (By similarity). Homodimer. Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S5, F-actin, SNAP25 isoform 1 and isoform 2, SNAP47 and STX12.
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
Subcellular Location:
Cytoplasm
Endomembrane system
Peripheral membrane protein
It can exist as a soluble protein as well as a peripheral membrane protein.
Protein Attributes:
50:
MSVPGPSSPD | GALTRPPYCL | EAGEPTPGLS | DTSPDEGLIE | DLTIEDKAVE |
100:
QLAEGLLSHY | LPDLQRSKQA | LQELTQNQVV | LLDTLEQEIS | KFKECHSMLD |
150:
INALFAEAKH | YHAKLVNIRK | EMLMLHEKTS | KLKKRALKLQ | QKRQKEELER |
172:
EQQREKEFER | EKQLTARPAK | RM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Human BLOC-1 subunit 6
ELISA Kit for Human BLOC-1 subunit 6
ELISA Kit for Human BLOC-1 subunit 6
ELISA Kit for Human BLOC-1 subunit 6
CLIA Kit for Human BLOC-1 subunit 6
CLIA Kit for Human BLOC-1 subunit 6
CLIA Kit for Human BLOC-1 subunit 6
CLIA Kit for Human BLOC-1 subunit 6
Polyclonal Antibody for Human BLOC-1 subunit 6
Polyclonal Antibody for Human BLOC-1 subunit 6
Polyclonal Antibody for Human BLOC-1 subunit 6
Polyclonal Antibody for Human BLOC-1 subunit 6
Monoclonal Antibody for Human BLOC-1 subunit 6
Monoclonal Antibody for Human BLOC-1 subunit 6
Monoclonal Antibody for Human BLOC-1 subunit 6
Monoclonal Antibody for Human BLOC-1 subunit 6
Protein for Human BLOC-1 subunit 6
Protein for Human BLOC-1 subunit 6
Protein for Human BLOC-1 subunit 6
Protein for Human BLOC-1 subunit 6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
2.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW;ALTERNATIVE SPLICING
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH STX12 AND BLOC1S5;HOMODIMERIZATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH BLOC1S5 AND F-ACTIN;HOMODIMERIZATION
7.
"BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."
Setty S.R.
,
Tenza D.
,
Truschel S.T.
,
Chou E.
,
Sviderskaya E.V.
,
Theos A.C.
,
Lamoreux M.L.
,
Di Pietro S.M.
,
Starcevic M.
,
Bennett D.C.
,
Dell'Angelica E.C.
,
Raposo G.
,
Marks M.S.
Mol. Biol. Cell18:768-780(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE BLOC-1 COMPLEX;FUNCTION
8.
"The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."
Ghiani C.A.
,
Starcevic M.
,
Rodriguez-Fernandez I.A.
,
Nazarian R.
,
Cheli V.T.
,
Chan L.N.
,
Malvar J.S.
,
de Vellis J.
,
Sabatti C.
,
Dell'Angelica E.C.
Mol. Psychiatry15:204-215(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE BLOC-1 COMPLEX;INTERACTION WITH SNAP25; SNAP47 AND STX12
9.
"A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9."
Cullinane A.R.
,
Curry J.A.
,
Carmona-Rivera C.
,
Summers C.G.
,
Ciccone C.
,
Cardillo N.D.
,
Dorward H.
,
Hess R.A.
,
White J.G.
,
Adams D.
,
Huizing M.
,
Gahl W.A.
Am. J. Hum. Genet.88:778-787(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HPS9
10.
"The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
Larimore J.
,
Tornieri K.
,
Ryder P.V.
,
Gokhale A.
,
Zlatic S.A.
,
Craige B.
,
Lee J.D.
,
Talbot K.
,
Pare J.F.
,
Smith Y.
,
Faundez V.
Mol. Biol. Cell22:4854-4867(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ASSOCIATION WITH THE AP-3 COMPLEX;INTERACTION WITH BLOC1S5
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE BLOC-1 COMPLEX;COMPOSITION OF THE BLOC-1 COMPLEX