Protein name:
Bone morphogenetic protein 10 (BMP-10) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGSLVLPLSA | VFCLVARLAS | GSPIMGLEQS | PLEEDMPFFD | DIFTEQDGID |
100:
FNTLLQSMKD | EFLKTLNLSD | IPPQDTGRVD | PPEYMLELYN | KFATDRTSMP |
150:
SANIIRSFKN | EDLFSQPVSF | NGIRKYPLLF | NVSIPHHEEV | VMAELRLYTL |
200:
VQRDRLMYDG | VDRKIIIFEV | LESADGSEDE | RSMLVLVSTE | IYGTNSEWET |
250:
FDITDATRRW | QKSGPSTHQL | EIHIESRQNQ | AEDTGRGQLE | IDMSAQNKHD |
300:
PLLVVFSDDQ | SGDKEQKEEL | NELISHEQDL | DLGTDGFFGG | PDEEALLQMR |
350:
SNMIDDSTAR | IRRNAKGNYC | KKTPLYIDFK | EIGWDSWIIA | PPGYEAYECR |
400:
GVCNYPLAEH | LTPTKHAIIQ | ALVHLKNSQK | ASKACCVPTK | LDPISILYLD |
421:
KGVVTYKFKY | EGMAVSECGC | R
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Rat BMP-10
Polyclonal Antibody for Rat BMP-10
Polyclonal Antibody for Rat BMP-10
Monoclonal Antibody for Rat BMP-10
Monoclonal Antibody for Rat BMP-10
Monoclonal Antibody for Rat BMP-10
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines."
Tsuji A.B.
,
Sugyo A.
,
Ogiu T.
,
Sagara M.
,
Kimura T.
,
Ishikawa A.
,
Sudo H.
,
Ohtsuki M.
,
Aburatani H.
,
Imai T.
,
Harada Y.N.
Genomics86:271-279(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Fischer 344/DuCrj .
strain :
LEC/Crj .