BRD4 ELISA Kit for Human(Homo sapiens) | EIAab.comBRD4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BRD4(Gene name) > Human

BRD4 (Gene name),

Bromodomain-containing protein 4 (Protein name ), BRD4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BRD4(HUNK1);

Protein name:

Bromodomain-containing protein 4;

Alternative:

Protein HUNK1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associated with chromosomes during mitosis (By similarity). Interacts with bovine papillomavirus type 1 regulatory protein E2.

Function:

Plays a role in a process governing chromosomal dynamics during mitosis.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1362

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1362:

SDLLSIFEEN | LF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00439

KEGG:

hsa:23476

String:

O60885

MIM:

608749

SMR:

O60885

UniGene:

Hs.187763

STRING:

9606.ENSP00000263377

Uniprot:

O60885

FOR

ELISA Kit for Human Bromodomain-containing protein 4

CLIA Kit for Human Bromodomain-containing protein 4

Polyclonal Antibody for Human Bromodomain-containing protein 4

Monoclonal Antibody for Human Bromodomain-containing protein 4

Protein for Human Bromodomain-containing protein 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)."
French C.A. , Miyoshi I. , Aster J.C. , Kubonishi I. , Kroll T.G. , Dal Cin P. , Vargas S.O. , Perez-Atayde A.R. , Fletcher J.A.
Am. J. Pathol.159:1987-1992(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);DISEASE;CHROMOSOMAL TRANSLOCATION WITH NUT
2.

Weber B.
Submitted (1997-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)
tissue: Placenta.
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
tissue: Testis.
6.

"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma."
French C.A. , Miyoshi I. , Kubonishi I. , Grier H.E. , Perez-Atayde A.R. , Fletcher J.A.
Cancer Res.63:304-307(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-719;DISEASE;CHROMOSOMAL TRANSLOCATION WITH NUT;TISSUE SPECIFICITY
tissue: Carcinoma.
7.

"The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription."
Jang M.K. , Mochizuki K. , Zhou M. , Jeong H.S. , Brady J.N. , Ozato K.
Mol. Cell19:523-534(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDK9 AND CCNT1;IDENTIFICATION IN THE P-TEFB COMPLEX;SUBCELLULAR LOCATION
8.

"Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4."
Yang Z. , Yik J.H. , Chen R. , He N. , Jang M.K. , Ozato K. , Zhou Q.
Mol. Cell19:535-545(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDK9 AND CCNT1;IDENTIFICATION IN THE P-TEFB COMPLEX
9.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1117;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes."
You J. , Srinivasan V. , Denis G.V. , Harrington W.J. Jr. , Ballestas M.E. , Kaye K.M. , Howley P.M.
J. Virol.80:8909-8919(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KSHV PROTEIN LANA
11.

"ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance."
Parish J.L. , Bean A.M. , Park R.B. , Androphy E.J.
Mol. Cell24:867-876(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BOVINE PAPILLOMAVIRUS TYPE 1 REGULATORY PROTEIN E2
12.

"The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4."
Lin A. , Wang S. , Nguyen T. , Shire K. , Frappier L.
J. Virol.82:12009-12019(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPSTEIN-BARR VIRUS PROTEIN EBNA1
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Control of inducible gene expression by signal-dependent transcriptional elongation."
Hargreaves D.C. , Horng T. , Medzhitov R.
Cell138:129-145(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA."
Huang B. , Yang X.D. , Zhou M.M. , Ozato K. , Chen L.F.
Mol. Cell. Biol.29:1375-1387(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RELA
17.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1111;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-1117;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."
Rahman S. , Sowa M.E. , Ottinger M. , Smith J.A. , Shi Y. , Harper J.W. , Howley P.M.
Mol. Cell. Biol.31:2641-2652(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WHSC1L1; JMJD6; CHD4; GLTSCR1 AND ATAD5
21.

"Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation."
Ai N. , Hu X. , Ding F. , Yu B. , Wang H. , Lu X. , Zhang K. , Li Y. , Han A. , Lin W. , Liu R. , Chen R.
Nucleic Acids Res.39:9592-9604(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601 AND SER-1117;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure."
Wang R. , Li Q. , Helfer C.M. , Jiao J. , You J.
J. Biol. Chem.287:10738-10752(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells."
Zhang W. , Prakash C. , Sum C. , Gong Y. , Li Y. , Kwok J.J. , Thiessen N. , Pettersson S. , Jones S.J. , Knapp S. , Yang H. , Chin K.C.
J. Biol. Chem.287:43137-43155(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
25.

"BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain."
Devaiah B.N. , Lewis B.A. , Cherman N. , Hewitt M.C. , Albrecht B.K. , Robey P.G. , Ozato K. , Sims R.J. III , Singer D.S.
Proc. Natl. Acad. Sci. U.S.A.109:6927-6932(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
26.

"Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting."
Wu S.Y. , Lee A.Y. , Lai H.T. , Zhang H. , Chiang C.M.
Mol. Cell49:843-857(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53;PHOSPHORYLATION AT SER-484; SER-488; SER-492; SER-494; SER-498; SER-499 AND SER-503;MUTAGENESIS OF 492-SER--SER-494; 498-SER--THR-500 AND SER-503
27.

"BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes."
Patel M.C. , Debrosse M. , Smith M. , Dey A. , Huynh W. , Sarai N. , Heightman T.D. , Tamura T. , Ozato K.
Mol. Cell. Biol.33:2497-2507(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"The bromodomain protein Brd4 insulates chromatin from DNA damage signalling."
Floyd S.R. , Pacold M.E. , Huang Q. , Clarke S.M. , Lam F.C. , Cannell I.G. , Bryson B.D. , Rameseder J. , Lee M.J. , Blake E.J. , Fydrych A. , Ho R. , Greenberger B.A. , Chen G.C. , Maffa A. , Del Rosario A.M. , Root D.E. , Carpenter A.E. , more...
Nature498:246-250(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM B);SUBCELLULAR LOCATION (ISOFORM B);INTERACTION WITH NCAPD3 AND SMC2;MUTAGENESIS OF ASN-140
29.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-37; GLY-371; ASN-563; SER-598 AND HIS-669
30.

"Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails."
Liu Y. , Wang X. , Zhang J. , Huang H. , Ding B. , Wu J. , Shi Y.
Biochemistry47:6403-6417(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 352-457
31.

"Selective inhibition of BET bromodomains."
Filippakopoulos P. , Qi J. , Picaud S. , Shen Y. , Smith W.B. , Fedorov O. , Morse E.M. , Keates T. , Hickman T.T. , Felletar I. , Philpott M. , Munro S. , McKeown M.R. , Wang Y. , Christie A.L. , West N. , Cameron M.J. , Schwartz B. , more...
Nature468:1067-1073(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 44-168 IN COMPLEX WITH JQ1 INHIBITOR;SUBCELLULAR LOCATION
32.

"Suppression of inflammation by a synthetic histone mimic."
Nicodeme E. , Jeffrey K.L. , Schaefer U. , Beinke S. , Dewell S. , Chung C.W. , Chandwani R. , Marazzi I. , Wilson P. , Coste H. , White J. , Kirilovsky J. , Rice C.M. , Lora J.M. , Prinjha R.K. , Lee K. , Tarakhovsky A.
Nature468:1119-1123(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 44-168 IN COMPLEX WITH I-BET INHIBITOR
33.

"Discovery and characterization of small molecule inhibitors of the BET family bromodomains."
Chung C.W. , Coste H. , White J.H. , Mirguet O. , Wilde J. , Gosmini R.L. , Delves C. , Magny S.M. , Woodward R. , Hughes S.A. , Boursier E.V. , Flynn H. , Bouillot A.M. , Bamborough P. , Brusq J.M. , Gellibert F.J. , Jones E.J. , Riou A.M. , more...
J. Med. Chem.54:3827-3838(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 44-168;X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 333-460
34.

"Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia."
Dawson M.A. , Prinjha R.K. , Dittmann A. , Giotopoulos G. , Bantscheff M. , Chan W.I. , Robson S.C. , Chung C.W. , Hopf C. , Savitski M.M. , Huthmacher C. , Gudgin E. , Lugo D. , Beinke S. , Chapman T.D. , Roberts E.J. , Soden P.E. , Auger K.R. , more...
Nature478:529-533(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 44-168 IN COMPLEX WITH JQ1 INHIBITOR
35.

"Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family."
Filippakopoulos P. , Picaud S. , Fedorov O. , Keller M. , Wrobel M. , Morgenstern O. , Bracher F. , Knapp S.
Bioorg. Med. Chem.20:1878-1886(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 44-168 IN COMPLEX WITH BENZODIAZEPINES AND BENZOTRIAZEPINES INHIBITORS
36.

"Down-regulation of NF-kappaB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition."
Zhang G. , Liu R. , Zhong Y. , Plotnikov A.N. , Zhang W. , Zeng L. , Rusinova E. , Gerona-Nevarro G. , Moshkina N. , Joshua J. , Chuang P.Y. , Ohlmeyer M. , He J.C. , Zhou M.M.
J. Biol. Chem.287:28840-28851(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 44-168;STRUCTURE BY NMR OF 333-460
37.

"Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery."
Chung C.W. , Dean A.W. , Woolven J.M. , Bamborough P.
J. Med. Chem.55:576-586(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 44-168 IN COMPLEX WITH BENZODIAZEPINES INHIBITORS
38.

"Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit."
Fish P.V. , Filippakopoulos P. , Bish G. , Brennan P.E. , Bunnage M.E. , Cook A.S. , Federov O. , Gerstenberger B.S. , Jones H. , Knapp S. , Marsden B. , Nocka K. , Owen D.R. , Philpott M. , Picaud S. , Primiano M.J. , Ralph M.J. , Sciammetta N. , more...
J. Med. Chem.55:9831-9837(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 44-168
39.

"Histone recognition and large-scale structural analysis of the human bromodomain family."
Filippakopoulos P. , Picaud S. , Mangos M. , Keates T. , Lambert J.P. , Barsyte-Lovejoy D. , Felletar I. , Volkmer R. , Muller S. , Pawson T. , Gingras A.C. , Arrowsmith C.H. , Knapp S.
Cell149:214-231(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 44-168; 333-460 AND 1343-1362 IN COMPLEX WITH ACETYLATED HISTONE;MUTAGENESIS OF ASN-140 AND ASN-433
40.

"Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands."
Hewings D.S. , Fedorov O. , Filippakopoulos P. , Martin S. , Picaud S. , Tumber A. , Wells C. , Olcina M.M. , Freeman K. , Gill A. , Ritchie A.J. , Sheppard D.W. , Russell A.J. , Hammond E.M. , Knapp S. , Brennan P.E. , Conway S.J.
J. Med. Chem.56:3217-3227(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 44-168 IN COMPLEX WITH 3,5-DIMETHYLISOXAZOLE INHIBITOR
41.

"Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain."
Zhao L. , Cao D. , Chen T. , Wang Y. , Miao Z. , Xu Y. , Chen W. , Wang X. , Li Y. , Du Z. , Xiong B. , Li J. , Xu C. , Zhang N. , He J. , Shen J.
J. Med. Chem.56:3833-3851(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 44-167 IN COMPLEX WITH 2-THIAZOLIDINONE INHIBITOR

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