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Index > Protein center > RNF40(Gene name) > Human
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  • RNF40 (Gene name),
  • E3 ubiquitin-protein ligase BRE1B (Protein name ),  BRE1B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RNF40(BRE1B;KIAA0661);
    Protein name:
    E3 ubiquitin-protein ligase BRE1B(BRE1-B);
    Alternative:
    RING finger protein 40;95 kDa retinoblastoma-associated protein(RBP95);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Component of the RNF20/40 complex at least composed of 2 copies of RNF20/BRE1A, 2 copies of RNF40/BRE1B and UBE2E1/UBCH6. Interacts with RB1 and WAC.
    Function:
    E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1001
    Sequence:
    50:
    MSGPGNKRAA | GDGGSGPPEK | KLSREEKTTT | TLIEPIRLGG | ISSTEEMDLK | 
    100:
    VLQFKNKKLA | ERLEQRQACE | DELRERIEKL | EKRQATDDAT | LLIVNRYWAQ | 
    150:
    LDETVEALLR | CHESQGELSS | APEAPGTQEG | PTCDGTPLPE | PGTSELRDPL | 
    200:
    LMQLRPPLSE | PALAFVVALG | ASSSEEVELE | LQGRMEFSKA | AVSRVVEASD | 
    250:
    RLQRRVEELC | QRVYSRGDSE | PLSEAAQAHT | RELGRENRRL | QDLATQLQEK | 
    300:
    HHRISLEYSE | LQDKVTSAET | KVLEMETTVE | DLQWDIEKLR | KREQKLNKHL | 
    350:
    AEALEQLNSG | YYVSGSSSGF | QGGQITLSMQ | KFEMLNAELE | ENQELANSRM | 
    400:
    AELEKLQAEL | QGAVRTNERL | KVALRSLPEE | VVRETGEYRM | LQAQFSLLYN | 
    450:
    ESLQVKTQLD | EARGLLLATK | NSHLRHIEHM | ESDELGLQKK | LRTEVIQLED | 
    500:
    TLAQVRKEYE | MLRIEFEQNL | AANEQAGPIN | REMRHLISSL | QNHNHQLKGD | 
    550:
    AQRYKRKLRE | VQAEIGKLRA | QASGSAHSTP | NLGHPEDSGV | SAPAPGKEEG | 
    600:
    GPGPVSTPDN | RKEMAPVPGT | TTTTTSVKKE | ELVPSEEDFQ | GITPGAQGPS | 
    650:
    SRGREPEARP | KRELQEREGP | SLGPPPVASA | LSRADREKAK | VEETKRKESE | 
    700:
    LLKGLRAELK | KAQESQKEMK | LLLDMYKSAP | KEQRDKVQLM | AAERKAKAEV | 
    750:
    DELRSRIREL | EERDRRESKK | IADEDALRRI | RQAEEQIEHL | QRKLGATKQE | 
    800:
    EEALLSEMDV | TGQAFEDMQE | QNGRLLQQLR | EKDDANFKLM | SERIKANQIH | 
    850:
    KLLREEKDEL | GEQVLGLKSQ | VDAQLLTVQK | LEEKERALQG | SLGGVEKELT | 
    900:
    LRSQALELNK | RKAVEAAQLA | EDLKVQLEHV | QTRLREIQPC | LAESRAAREK | 
    950:
    ESFNLKRAQE | DISRLRRKLE | KQRKVEVYAD | ADEILQEEIK | EYKARLTCPC | 
    1000:
    CNTRKKDAVL | TKCFHVFCFE | CVRGRYEARQ | RKCPKCNAAF | GAHDFHRIYI | 
    1001:
    S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human BRE1-B
    ELISA Kit for Human BRE1-B
    ELISA Kit for Human BRE1-B
    CLIA Kit for Human BRE1-B
    CLIA Kit for Human BRE1-B
    CLIA Kit for Human BRE1-B
    Polyclonal Antibody for Human BRE1-B
    Polyclonal Antibody for Human BRE1-B
    Polyclonal Antibody for Human BRE1-B
    Monoclonal Antibody for Human BRE1-B
    Monoclonal Antibody for Human BRE1-B
    Monoclonal Antibody for Human BRE1-B
    Protein for Human BRE1-B
    Protein for Human BRE1-B
    Protein for Human BRE1-B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein."
      Wen H. , Ao S.
      Biochem. Biophys. Res. Commun.275:141-148(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;SUBUNIT;INTERACTION WITH RB1;MUTAGENESIS OF LEU-109; CYS-111 AND GLU-113;VARIANT ARG-615
      tissue: Fetal brain.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-615
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT ARG-615
      tissue: Teratocarcinoma.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-615
      tissue: Cervix.
      tissue: Rectum tumor.
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-615
      tissue: Brain.
      tissue: Mammary gland.
      tissue: Skin.
      tissue: Uterus.
    7. 7.
      "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."
      Zhu B. , Zheng Y. , Pham A.-D. , Mandal S.S. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
      Mol. Cell20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;IDENTIFICATION IN A COMPLEX WITH RNF20 AND UBE2E1
    8. 8.
      "RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells."
      Kim J. , Guermah M. , McGinty R.K. , Lee J.S. , Tang Z. , Milne T.A. , Shilatifard A. , Muir T.W. , Roeder R.G.
      Cell137:459-471(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."
      Zhang F. , Yu X.
      Mol. Cell41:384-397(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WAC
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