BRE ELISA Kit for Bovine(Bos taurus) | EIAab.comBRE ELISA Kit for Bovine(Bos taurus)

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BRE (Gene name),

BRCA1-A complex subunit BRE (Protein name ), BRE_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BRE;

Protein name:

BRCA1-A complex subunit BRE;

Alternative:

Brain and reproductive organ-expressed protein;BRCA1/BRCA2-containing complex subunit 45;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.

Function:

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin.

Subcellular Location:

Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).

Protein Attributes:

Sequence length:

383

Sequence:

50:

100:

150:

200:

250:

300:

350:

383:

PRWDGNEMAK | RAKAYFKTFV | PQFQEAAFAN | GKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF06113

STRING:

9913.ENSBTAP00000041902

KEGG:

bta:614152

UniGene:

Bt.4351

String:

A6QQW8

Uniprot:

A6QQW8

FOR

ELISA Kit for Bovine BRCA1-A complex subunit BRE

CLIA Kit for Bovine BRCA1-A complex subunit BRE

Polyclonal Antibody for Bovine BRCA1-A complex subunit BRE

Monoclonal Antibody for Bovine BRCA1-A complex subunit BRE

Protein for Bovine BRCA1-A complex subunit BRE

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Thymus.

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