BRE ELISA Kit for Chicken(Gallus gallus) | EIAab.comBRE ELISA Kit for Chicken(Gallus gallus)

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BRE (Gene name),

BRCA1-A complex subunit BRE (Protein name ), BRE_CHICK from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

BRE(RCJMB04_1l17);

Protein name:

BRCA1-A complex subunit BRE;

Alternative:

Brain and reproductive organ-expressed protein;BRCA1/BRCA2-containing complex subunit 45;

Organism:

Chicken (Gallus gallus).

General Annotation

Sub Unit:

Component of the BRCA1-A complex. Component of the BRISC complex.

Function:

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin.

Subcellular Location:

Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).

Protein Attributes:

Sequence length:

383

Sequence:

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