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Index > Protein center > BRE(Gene name) > Human
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  • BRE (Gene name),
  • BRCA1-A complex subunit BRE (Protein name ),  BRE_HUMAN from NCBI database.
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  • Gene name:
    BRE(BRCC45);
    Protein name:
    BRCA1-A complex subunit BRE;
    Alternative:
    Brain and reproductive organ-expressed protein;BRCA1/BRCA2-containing complex subunit 45;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.
    Function:
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
    Subcellular Location:
    Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks.
    Protein Attributes:
    Sequence length:
    383
    Sequence:
    50:
    MSPEVALNRI | SPMLSPFISS | VVRNGKVGLD | ATNCLRITDL | KSGCTSLTPG | 
    100:
    PNCDRFKLHI | PYAGETLKWD | IIFNAQYPEL | PPDFIFGEDA | EFLPDPSALQ | 
    150:
    NLASWNPSNP | ECLLLVVKEL | VQQYHQFQCS | RLRESSRLMF | EYQTLLEEPQ | 
    200:
    YGENMEIYAG | KKNNWTGEFS | ARFLLKLPVD | FSNIPTYLLK | DVNEDPGEDV | 
    250:
    ALLSVSFEDT | EATQVYPKLY | LSPRIEHALG | GSSALHIPAF | PGGGCLIDYV | 
    300:
    PQVCHLLTNK | VQYVIQGYHK | RREYIAAFLS | HFGTGVVEYD | AEGFTKLTLL | 
    350:
    LMWKDFCFLV | HIDLPLFFPR | DQPTLTFQSV | YHFTNSGQLY | SQAQKNYPYS | 
    383:
    PRWDGNEMAK | RAKAYFKTFV | PQFQEAAFAN | GKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human BRCA1-A complex subunit BRE
    ELISA Kit for Human BRCA1-A complex subunit BRE
    ELISA Kit for Human BRCA1-A complex subunit BRE
    ELISA Kit for Human BRCA1-A complex subunit BRE
    ELISA Kit for Human BRCA1-A complex subunit BRE
    CLIA Kit for Human BRCA1-A complex subunit BRE
    CLIA Kit for Human BRCA1-A complex subunit BRE
    CLIA Kit for Human BRCA1-A complex subunit BRE
    CLIA Kit for Human BRCA1-A complex subunit BRE
    CLIA Kit for Human BRCA1-A complex subunit BRE
    Polyclonal Antibody for Human BRCA1-A complex subunit BRE
    Polyclonal Antibody for Human BRCA1-A complex subunit BRE
    Polyclonal Antibody for Human BRCA1-A complex subunit BRE
    Polyclonal Antibody for Human BRCA1-A complex subunit BRE
    Polyclonal Antibody for Human BRCA1-A complex subunit BRE
    Monoclonal Antibody for Human BRCA1-A complex subunit BRE
    Monoclonal Antibody for Human BRCA1-A complex subunit BRE
    Monoclonal Antibody for Human BRCA1-A complex subunit BRE
    Monoclonal Antibody for Human BRCA1-A complex subunit BRE
    Monoclonal Antibody for Human BRCA1-A complex subunit BRE
    Protein for Human BRCA1-A complex subunit BRE
    Protein for Human BRCA1-A complex subunit BRE
    Protein for Human BRCA1-A complex subunit BRE
    Protein for Human BRCA1-A complex subunit BRE
    Protein for Human BRCA1-A complex subunit BRE

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    References
    1. 1.
      "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid."
      Li L. , Yoo H. , Becker F.F. , Ali-Osman F. , Chan J.Y.-H.
      Biochem. Biophys. Res. Commun.206:764-774(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);TISSUE SPECIFICITY;INDUCTION
      tissue: Monocyte.
    3. 3.
      "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair."
      Dong Y. , Hakimi M.-A. , Chen X. , Kumaraswamy E. , Cooch N.S. , Godwin A.K. , Shiekhattar R.
      Mol. Cell12:1087-1099(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;IDENTIFICATION IN BRCC COMPLEX
    4. 4.
      Keeton K.R. , Miles W.M.
      Submitted (1997-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Teratocarcinoma.
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Cervix.
    9. 9.
      "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."
      Li Q. , Ching A.K.-K. , Chan B.C.-L. , Chow S.K.-Y. , Lim P.-L. , Ho T.C.-Y. , Ip W.-K. , Wong C.-K. , Lam C.W.-K. , Lee K.K.-H. , Chan J.Y.-H. , Chui Y.-L.
      J. Biol. Chem.279:52106-52116(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FAS AND TNFRSF1A;SUBCELLULAR LOCATION
    10. 10.
      "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites."
      Sobhian B. , Shao G. , Lilli D.R. , Culhane A.C. , Moreau L.A. , Xia B. , Livingston D.M. , Greenberg R.A.
      Science316:1198-1202(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."
      Cooper E.M. , Cutcliffe C. , Kristiansen T.Z. , Pandey A. , Pickart C.M. , Cohen R.E.
      EMBO J.28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRISC COMPLEX
    13. 13.
      "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."
      Shao G. , Patterson-Fortin J. , Messick T.E. , Feng D. , Shanbhag N. , Wang Y. , Greenberg R.A.
      Genes Dev.23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX
    14. 14.
      "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."
      Wang B. , Hurov K. , Hofmann K. , Elledge S.J.
      Genes Dev.23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE BRCA1-A COMPLEX;DOMAIN UEV-LIKE;UBIQUITIN-BINDING;INTERACTION WITH FAM175A
    15. 15.
      "MERIT40 facilitates BRCA1 localization and DNA damage repair."
      Feng L. , Huang J. , Chen J.
      Genes Dev.23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE BRCA1-A COMPLEX;SUBCELLULAR LOCATION;INTERACTION WITH FAM175A; BABAM1 AND BRCC3
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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