BRMS1 ELISA Kit for Human(Homo sapiens) | EIAab.comBRMS1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BRMS1(Gene name) > Human

BRMS1 (Gene name),

Breast cancer metastasis-suppressor 1 (Protein name ), BRMS1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BRMS1;

Protein name:

Breast cancer metastasis-suppressor 1;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2.

Function:

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Subcellular Location:

Nucleus Cytoplasm Predominantly nuclear.

Protein Attributes:

Sequence length:

246

Sequence:

50:

100:

150:

200:

246:

KRKKAPLVSG | PYIVYMLQEI | DILEDWTAIK | KARAAVSPQK | RKSDGP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08598

STRING:

9606.ENSP00000396052

KEGG:

hsa:25855

String:

Q9HCU9

MIM:

606259

SMR:

Q9HCU9

UniGene:

Hs.100426

Uniprot:

Q9HCU9

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ELISA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

E9631h

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MSDS:

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Packing:

96T

ELISA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

E9631m

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MSDS:

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Packing:

96T

ELISA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

E9631r

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MSDS:

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96T

ELISA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

E9631b

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MSDS:

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Packing:

96T

CLIA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

U9631r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

U9631h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

U9631b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Breast cancer metastasis-suppressor 1

Cat.:

U9631m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Breast cancer metastasis-suppressor 1

Cat.:

P9631Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Breast cancer metastasis-suppressor 1

Cat.:

P9631Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Breast cancer metastasis-suppressor 1

Cat.:

P9631Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Breast cancer metastasis-suppressor 1

Protein for Human Breast cancer metastasis-suppressor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13."
Seraj M.J. , Samant R.S. , Verderame M.F. , Welch D.R.
Cancer Res.60:2764-2769(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
2.

"Genomic structure and chromosomal localization of the breast metastasis suppressor gene, BRMS1."
Welch D.R. , Samant R.S. , Debies M.T. , Seraj M.J. , Verderame M.F.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
6.

"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
Janneau J.-L. , Maldonado-Estrada J. , Tachdjian G. , Miran I. , Motte N. , Saulnier P. , Sabourin J.-C. , Cote J.-F. , Simon B. , Frydman R. , Chaouat G. , Bellet D.
J. Clin. Endocrinol. Metab.87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS
7.

"Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription."
Meehan W.J. , Samant R.S. , Hopper J.E. , Carrozza M.J. , Shevde L.A. , Workman J.L. , Eckert K.A. , Verderame M.F. , Welch D.R.
J. Biol. Chem.279:1562-1569(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARID4A;IDENTIFICATION IN A COMPLEX WITH SIN3A; SIN3B; HDAC1; HDAC2; SAP30; SUDS3; RBBP4 AND RBBP7
8.

"Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis."
Liu Y. , Smith P.W. , Jones D.R.
Mol. Cell. Biol.26:8683-8696(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HDAC1 AND RELA
9.

"Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression."
Rivera J. , Megias D. , Bravo J.
J. Cell. Biochem.111:1464-1472(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SNX6
10.

"Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex."
Kim B. , Nam H.J. , Pyo K.E. , Jang M.J. , Kim I.S. , Kim D. , Boo K. , Lee S.H. , Yoon J.B. , Baek S.H. , Kim J.H.
Biochem. Biophys. Res. Commun.415:720-726(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;SUBCELLULAR LOCATION;INTERACTION WITH SPOP;IDENTIFICATION IN A COMPLEX WITH CUL3 AND SPOP
11.

"The structure of BRMS1 nuclear export signal and SNX6 interacting region reveals a hexamer formed by antiparallel coiled coils."
Spinola-Amilibia M. , Rivera J. , Ortiz-Lombardia M. , Romero A. , Neira J.L. , Bravo J.
J. Mol. Biol.411:1114-1127(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 51-98;COILED-COIL DOMAIN;SUBUNIT

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