Protein name:
Bone marrow stromal antigen 2 (BST-2) ;
Alternative:
Tetherin ;HM1.24 antigen ;
CD:
CD317 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Parralel homodimer; disulfide-linked. May form homotetramers under reducing conditions.
Function:
May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.
Subcellular Location:
Golgi apparatus
trans-Golgi network
Cell membrane
Single-pass type II membrane protein
Cell membrane
Lipid-anchor
GPI-anchor
Late endosome
Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein.
Protein Attributes:
50:
MASTSYDYCR | VPMEDGDKRC | KLLLGIGILV | LLIIVILGVP | LIIFTIKANS |
100:
EACRDGLRAV | MECRNVTHLL | QQELTEAQKG | FQDVEAQAAT | CNHTVMALMA |
150:
SLDAEKAQGQ | KKVEELEGEI | TTLNHKLQDA | SAEVERLRRE | NQVLSVRIAD |
180:
KKYYPSSQDS | SSAAAPQLLI | VLLGLSALLQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human BST-2
ELISA Kit for Human BST-2
ELISA Kit for Human BST-2
Polyclonal Antibody for Human BST-2
Polyclonal Antibody for Human BST-2
Polyclonal Antibody for Human BST-2
Monoclonal Antibody for Human BST-2
Monoclonal Antibody for Human BST-2
Monoclonal Antibody for Human BST-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Blood .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION BY B-CELL ACTIVATION;NOMENCLATURE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GPI-ANCHOR [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HIV-1 INFECTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HIV-1 INFECTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HIV-1 INFECTION;GLYCOSYLATION AT ASN-65 AND ASN-92;SUBCELLULAR LOCATION;DISULFIDE BONDS;SUBUNIT;TOPOLOGY;GPI-ANCHOR;MUTAGENESIS OF ASN-65 AND ASN-92
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 VPU;INDUCTION BY HIV-1 VPU
15.
"Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction."
Cao W.
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Cho M.
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Bao M.
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Rosen D.B.
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Liu Y.J.
J. Exp. Med.206:1603-1614(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH LILRA4/ILT7
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65
tissue :
Liver .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-2 ENV;SUBCELLULAR LOCATION;INDUCTION BY HIV-2 ENV
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65
tissue :
Leukemic T-cell .
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH EBOLA GP PROTEIN;INDUCTION BY EBOLA GP PROTEIN
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-65 AND ASN-92;SUBUNIT;DISULFIDE BONDS
22.
"Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin."
Radoshitzky S.R.
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J. Virol.84:10569-10580(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;SUBCELLULAR LOCATION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
24.
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Cited for : FUNCTION IN KSHV AND HIV-1 INFECTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-18 AND LYS-21;UBIQUITINATION AT LYS-18 BY KSH VIRUS E3 UBIQUITIN-PROTEIN LIGASE K5
25.
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Cited for : REVIEW
26.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
28.
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Cited for : REVIEW
29.
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Cited for : REVIEW
30.
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Cited for : FUNCTION
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
34.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MMP14
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
36.
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Cited for : FUNCTION;SUBUNIT;ALTERNATIVE INITIATION (ISOFORMS 1 AND 2);INDUCTION;MUTAGENESIS OF 3-SER--SER-5; TYR-6 AND TYR-8
37.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
38.
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Cited for : FUNCTION
39.
"Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain."
Hinz A.
,
Miguet N.
,
Natrajan G.
,
Usami Y.
,
Yamanaka H.
,
Renesto P.
,
Hartlieb B.
,
McCarthy A.A.
,
Simorre J.P.
,
Gottlinger H.
,
Weissenhorn W.
Cell Host Microbe7:314-323(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.77 ANGSTROMS) OF 87-147;FUNCTION;DOMAIN;DISULFIDE BONDS;SUBUNIT;SUBCELLULAR LOCATION;CIRCULAR DICHROISM
40.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 47-152;SUBUNIT;DISULFIDE BONDS
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 47-161;SUBUNIT;FUNCTION;DISULFIDE BONDS