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Index > Protein center > Bub3(Gene name) > Mouse
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  • Bub3 (Gene name),
  • Mitotic checkpoint protein BUB3 (Protein name ),  BUB3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Bub3;
    Protein name:
    Mitotic checkpoint protein BUB3;
    Alternative:
    WD repeat type I transmembrane protein A72.5;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1.
    Function:
    Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis.
    Subcellular Location:
    Nucleus Chromosome centromere kinetochore Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
    Protein Attributes:
    Sequence length:
    326
    Sequence:
    50:
    MTGSNEFKLN | QPPEDGISSV | KFSPNTSQFL | LVSSWDTSVR | LYDVPANSMR | 
    100:
    LKYQHTGAVL | DCAFYDPTHA | WSGGLDHQLK | MHDLNTDQEN | LVGTHDAPIR | 
    150:
    CVEYCPEVNV | MVTGSWDQTV | KLWDPRTPCN | AGTFSQPEKV | YTLSVSGDRL | 
    200:
    IVGTAGRRVL | VWDLRNMGYV | QQRRESSLKY | QTRCIRAFPN | KQGYVLSSIE | 
    250:
    GRVAVEYLDP | SPEVQKKKYA | FKCHRLKENN | IEQIYPVNAI | SFHNIHNTFA | 
    300:
    TGGSDGFVNI | WDPFNKKRLC | QFHRYPTSIA | SLAFSNDGTT | LAIASSYMYE | 
    326:
    MDDTEHPEDG | IFIRQVTDAE | TKPKST
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Mitotic checkpoint protein BUB3
    ELISA Kit for Mouse Mitotic checkpoint protein BUB3
    ELISA Kit for Mouse Mitotic checkpoint protein BUB3
    CLIA Kit for Mouse Mitotic checkpoint protein BUB3
    CLIA Kit for Mouse Mitotic checkpoint protein BUB3
    CLIA Kit for Mouse Mitotic checkpoint protein BUB3
    Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
    Protein for Mouse Mitotic checkpoint protein BUB3
    Protein for Mouse Mitotic checkpoint protein BUB3
    Protein for Mouse Mitotic checkpoint protein BUB3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Retention of the BUB3 checkpoint protein on lagging chromosomes."
      Martinez-Exposito M.J. , Kaplan K.B. , Copeland J. , Sorger P.K.
      Proc. Natl. Acad. Sci. U.S.A.96:8493-8498(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Embryo.
    2. 2.
      Downs A. , Xie X. , Yan W. , Li J. , Palacios R.
      Submitted (1996-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X 129/Sv.
      tissue: Bone marrow.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      tissue: Mammary tumor.
    5. 5.
      "Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated."
      Saxena A. , Saffery R. , Wong L.H. , Kalitsis P. , Choo K.H.
      J. Biol. Chem.277:26921-26926(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLY-ADP-RIBOSYLATION BY PARP1
    6. 6.
      "Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis."
      Li M. , Li S. , Yuan J. , Wang Z.B. , Sun S.C. , Schatten H. , Sun Q.Y.
      PLoS ONE4:E7701-E7701(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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