Protein name:
Mitotic checkpoint protein BUB3 ;
Alternative:
WD repeat type I transmembrane protein A72.5 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1.
Function:
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis.
Subcellular Location:
Nucleus
Chromosome
centromere
kinetochore
Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
Protein Attributes:
50:
MTGSNEFKLN | QPPEDGISSV | KFSPNTSQFL | LVSSWDTSVR | LYDVPANSMR |
100:
LKYQHTGAVL | DCAFYDPTHA | WSGGLDHQLK | MHDLNTDQEN | LVGTHDAPIR |
150:
CVEYCPEVNV | MVTGSWDQTV | KLWDPRTPCN | AGTFSQPEKV | YTLSVSGDRL |
200:
IVGTAGRRVL | VWDLRNMGYV | QQRRESSLKY | QTRCIRAFPN | KQGYVLSSIE |
250:
GRVAVEYLDP | SPEVQKKKYA | FKCHRLKENN | IEQIYPVNAI | SFHNIHNTFA |
300:
TGGSDGFVNI | WDPFNKKRLC | QFHRYPTSIA | SLAFSNDGTT | LAIASSYMYE |
326:
MDDTEHPEDG | IFIRQVTDAE | TKPKST
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Mouse Mitotic checkpoint protein BUB3
ELISA Kit for Mouse Mitotic checkpoint protein BUB3
ELISA Kit for Mouse Mitotic checkpoint protein BUB3
CLIA Kit for Mouse Mitotic checkpoint protein BUB3
CLIA Kit for Mouse Mitotic checkpoint protein BUB3
CLIA Kit for Mouse Mitotic checkpoint protein BUB3
Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Polyclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Monoclonal Antibody for Mouse Mitotic checkpoint protein BUB3
Protein for Mouse Mitotic checkpoint protein BUB3
Protein for Mouse Mitotic checkpoint protein BUB3
Protein for Mouse Mitotic checkpoint protein BUB3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Embryo .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 X 129/Sv .
tissue :
Bone marrow .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
tissue :
Thymus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Czech II .
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POLY-ADP-RIBOSYLATION BY PARP1
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION