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Index > Protein center > C1D(Gene name) > Human
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  • C1D (Gene name),
  • Nuclear nucleic acid-binding protein C1D (Protein name ),  C1D_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C1D;
    Protein name:
    Nuclear nucleic acid-binding protein C1D(hC1D);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3.
    Function:
    Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.
    Subcellular Location:
    Cytoplasm Nucleus nucleolus EXOSC10 is required for nucleolar localization.
    Protein Attributes:
    Sequence length:
    141
    Sequence:
    50:
    MAGEEINEDY | PVEIHEYLSA | FENSIGAVDE | MLKTMMSVSR | NELLQKLDPL | 
    100:
    EQAKVDLVSA | YTLNSMFWVY | LATQGVNPKE | HPVKQELERI | RVYMNRVKEI | 
    141:
    TDKKKAGKLD | RGAASRFVKN | ALWEPKSKNA | SKVANKGKSK | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human hC1D
    ELISA Kit for Human hC1D
    ELISA Kit for Human hC1D
    ELISA Kit for Human hC1D
    CLIA Kit for Human hC1D
    CLIA Kit for Human hC1D
    CLIA Kit for Human hC1D
    CLIA Kit for Human hC1D
    Polyclonal Antibody for Human hC1D
    Polyclonal Antibody for Human hC1D
    Polyclonal Antibody for Human hC1D
    Polyclonal Antibody for Human hC1D
    Monoclonal Antibody for Human hC1D
    Monoclonal Antibody for Human hC1D
    Monoclonal Antibody for Human hC1D
    Monoclonal Antibody for Human hC1D
    Protein for Human hC1D
    Protein for Human hC1D
    Protein for Human hC1D
    Protein for Human hC1D

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning, recombinant expression and characterization of polypeptides with exceptional DNA affinity."
      Nehls P. , Keck T. , Greferath R. , Spiess E. , Glaser T. , Rothbarth K. , Stammer H. , Werner D.
      Nucleic Acids Res.26:1160-1166(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT
      tissue: Term placenta.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
      tissue: Lung.
      tissue: Uterus.
    6. 6.
      "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D."
      Yavuzer U. , Smith G.C.M. , Bliss T. , Werner D. , Jackson S.P.
      Genes Dev.12:2188-2199(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;PHOSPHORYLATION;INTERACTION WITH PRKDC
    7. 7.
      "Identification of a novel Rac3-interacting protein C1D."
      Haataja L. , Groffen J. , Heisterkamp N.
      Int. J. Mol. Med.1:665-670(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAC3
    8. 8.
      "Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D."
      Rothbarth K. , Spiess E. , Juodka B. , Yavuzer U. , Nehls P. , Stammer H. , Werner D.
      J. Cell Sci.112:2223-2232(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    9. 9.
      "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)."
      Erdemir T. , Bilican B. , Oncel D. , Goding C.R. , Yavuzer U.
      J. Cell Sci.115:207-216(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TSNAX
    10. 10.
      "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing."
      Schilders G. , van Dijk E. , Pruijn G.J.M.
      Nucleic Acids Res.35:2564-2572(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH EXOSC10
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