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Index > Protein center > CDC42SE1(Gene name) > Human
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  • CDC42SE1 (Gene name),
  • CDC42 small effector protein 1 (Protein name ),  C42S1_HUMAN from NCBI database.
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  • Gene name:
    CDC42SE1(SPEC1);
    Protein name:
    CDC42 small effector protein 1;
    Alternative:
    Small effector of CDC42 protein 1;CDC42-binding protein SCIP1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
    Function:
    Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell membrane Lipid-anchor Recruited to the activated TCR prior actin polymerization.
    Protein Attributes:
    Sequence length:
    79
    Sequence:
    50:
    MSEFWHKLGC | CVVEKPQPKK | KRRRIDRTMI | GEPMNFVHLT | HIGSGEMGAG | 
    79:
    DGLAMTGAVQ | EQMRSKGNRD | RPWSNSRGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CDC42 small effector protein 1
    ELISA Kit for Human CDC42 small effector protein 1
    ELISA Kit for Human CDC42 small effector protein 1
    ELISA Kit for Human CDC42 small effector protein 1
    ELISA Kit for Human CDC42 small effector protein 1
    CLIA Kit for Human CDC42 small effector protein 1
    CLIA Kit for Human CDC42 small effector protein 1
    CLIA Kit for Human CDC42 small effector protein 1
    CLIA Kit for Human CDC42 small effector protein 1
    CLIA Kit for Human CDC42 small effector protein 1
    Polyclonal Antibody for Human CDC42 small effector protein 1
    Polyclonal Antibody for Human CDC42 small effector protein 1
    Polyclonal Antibody for Human CDC42 small effector protein 1
    Polyclonal Antibody for Human CDC42 small effector protein 1
    Polyclonal Antibody for Human CDC42 small effector protein 1
    Monoclonal Antibody for Human CDC42 small effector protein 1
    Monoclonal Antibody for Human CDC42 small effector protein 1
    Monoclonal Antibody for Human CDC42 small effector protein 1
    Monoclonal Antibody for Human CDC42 small effector protein 1
    Monoclonal Antibody for Human CDC42 small effector protein 1
    Protein for Human CDC42 small effector protein 1
    Protein for Human CDC42 small effector protein 1
    Protein for Human CDC42 small effector protein 1
    Protein for Human CDC42 small effector protein 1
    Protein for Human CDC42 small effector protein 1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CDC42;MUTAGENESIS OF PRO-33; HIS-38; HIS-41; GLN-62 AND LYS-66
    2. 2.
      "The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene."
      Pirone D.M. , Oberst M.D. , Stylianou D. , Burbelo P.D.
      Gene273:295-303(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    6. 6.
      "Cloning and characterization of a small, CRIB-containing, Cdc42-binding protein."
      Mitina O.V. , Serebriiskii I.G. , Chernoff J.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-79 (ISOFORM 1)
    7. 7.
      "The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse."
      Ching K.H. , Kisailus A.E. , Burbelo P.D.
      J. Biol. Chem.280:23660-23667(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PROBABLE PALMITOYLATION;MUTAGENESIS OF 10-CYS-CYS-11; PRO-33; HIS-38 AND HIS-41
    8. 8.
      "Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis."
      Ching K.H. , Kisailus A.E. , Burbelo P.D.
      Exp. Cell Res.313:10-21(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHOINOSITIDE-BINDING
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