C5AR2 ELISA Kit for Human(Homo sapiens) | EIAab.comC5AR2 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > C5AR2(Gene name) > Human

C5AR2 (Gene name),

C5a anaphylatoxin chemotactic receptor 2 (Protein name ), C5AR2_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

C5AR2(C5L2;GPR77);

Protein name:

C5a anaphylatoxin chemotactic receptor 2;

Alternative:

G-protein coupled receptor 77;Complement component 5a receptor 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.

Function:

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

337

Sequence:

50:

100:

150:

200:

250:

300:

337:

RSLPAACHWA | LRESQGQDES | VDSKKSTSHD | LVSEMEV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000257267

MIM:

609949

UniGene:

Hs.534412

KEGG:

hsa:27202

Pfam:

PF00001

SMR:

Q9P296

Uniprot:

Q9P296

FOR

ELISA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

E12838m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

E12838h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

E12838r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

U12838r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

U12838h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

U12838m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

P12838Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

P12838Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human C5a anaphylatoxin chemotactic receptor 2

Cat.:

P12838Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human C5a anaphylatoxin chemotactic receptor 2

Protein for Human C5a anaphylatoxin chemotactic receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells."
Ohno M. , Hirata T. , Enomoto M. , Araki T. , Ishimaru H. , Takahashi T.A.
Mol. Immunol.37:407-412(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Placenta.
2.

"Identification of four novel human G protein-coupled receptors expressed in the brain."
Lee D.K. , George S.R. , Cheng R. , Nguyen T. , Liu Y. , Brown M. , Lynch K.R. , O'Dowd B.F.
Brain Res. Mol. Brain Res.86:13-22(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
3.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Trachea.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74)."
Cain S.A. , Monk P.N.
J. Biol. Chem.277:7165-7169(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
tissue: Brain.
9.

"The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein."
Kalant D. , Cain S.A. , Maslowska M. , Sniderman A.D. , Cianflone K. , Monk P.N.
J. Biol. Chem.278:11123-11129(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C3 ADIOPOGENIC PEPTIDE ASP
10.

"C5L2 is a functional receptor for acylation-stimulating protein."
Kalant D. , MacLaren R. , Cui W. , Samanta R. , Monk P.N. , Laporte S.A. , Cianflone K.
J. Biol. Chem.280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR THE C3 ADIOPOGENIC PEPTIDE ASP
11.

"C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation."
Cui W. , Simaan M. , Laporte S. , Lodge R. , Cianflone K.
Mol. Immunol.46:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT ILE-323
12.

"Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia."
Marcil M. , Vu H. , Cui W. , Dastani Z. , Engert J.C. , Gaudet D. , Castro-Cabezas M. , Sniderman A.D. , Genest J. Jr. , Cianflone K.
Arterioscler. Thromb. Vasc. Biol.26:1619-1625(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-323
13.

"Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease."
Zheng Y.Y. , Xie X. , Ma Y.T. , Yang Y.N. , Fu Z.Y. , Li X.M. , Ma X. , Chen B.D. , Liu F.
PLoS ONE6:E20984-E20984(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-233

Product Feedback Wall

* Email:
*Comments: