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Index > Protein center > CASP8AP2(Gene name) > Human
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  • CASP8AP2 (Gene name),
  • CASP8-associated protein 2 (Protein name ),  C8AP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CASP8AP2(FLASH;KIAA1315;RIP25);
    Protein name:
    CASP8-associated protein 2;
    Alternative:
    FLICE-associated huge protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2, NCOA3, SRRT/ARS2 and TRAF2. Interacts with NPAT.
    Function:
    Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
    Subcellular Location:
    Cytoplasm Nucleus Localizes to discrete nuclear foci.
    Protein Attributes:
    Sequence length:
    1982
    Sequence:
    50:
    MAADDDNGDG | TSLFDVFSAS | PLKNNDEGSL | DIYAGLDSAV | SDSASKSCVP | 
    100:
    SRNCLDLYEE | ILTEEGTAKE | ATYNDLQVEY | GKCQLQMKEL | MKKFKEIQTQ | 
    150:
    NFSLINENQS | LKKNISALIK | TARVEINRKD | EEISNLHQRL | SEFPHFRNNH | 
    200:
    KTARTFDTVK | TKDLKSRSPH | LDDCSKTDHR | AKSDVSKDVH | HSTSLPNLEK | 
    250:
    EGKPHSDKRS | TSHLPTSVEK | HCTNGVWSRS | HYQVGEGSSN | EDSRRGRKDI | 
    300:
    RHSQFNRGTE | RVRKDLSTGC | GDGEPRILEA | SQRLQGHPEK | YGKGEPKTES | 
    350:
    KSSKFKSNSD | SDYKGERINS | SWEKETPGER | SHSRVDSQSD | KKLERQSERS | 
    400:
    QNINRKEVKS | QDKEERKVDQ | KPKSVVKDQD | HWRRSERASL | PHSKNEITFS | 
    450:
    HNSSKYHLEE | RRGWEDCKRD | KSVNSHSFQD | GRCPSSLSNS | RTHKNIDSKE | 
    500:
    VDAMHQWENT | PLKAERHRTE | DKRKREQESK | EENRHIRNEK | RVPTEHLQKT | 
    550:
    NKETKKTTTD | LKKQNEPKTD | KGEVLDNGVS | EGADNKELAM | KAESGPNETK | 
    600:
    NKDLKLSFMK | KLNLTLSPAK | KQPVSQDNQH | KITDIPKSSG | VCDSESSMQV | 
    650:
    KTVAYVPSIS | EHILGEAAVS | EHTMGETKST | LLEPKVALLA | VTEPRIGISE | 
    700:
    TNKEDENSLL | VRSVDNTMHC | EEPICGTETS | FPSPMEIQQT | ESLFPSTGMK | 
    750:
    QTINNGRAAA | PVVMDVLQTD | VSQNFGLELD | TKRNDNSDYC | GISEGMEMKV | 
    800:
    ALSTTVSETT | ESILQPSIEE | ADILPIMLSE | DNNPKFEPSV | IVTPLVESKS | 
    850:
    CHLEPCLPKE | TLDSSLQQTE | LMDHRMATGE | TNSVYHDDDN | SVLSIDLNHL | 
    900:
    RPIPEAISPL | NSPVRPVAKV | LRNESPPQVP | VYNNSHKDVF | LPNSAHSTSK | 
    950:
    SQSDLNKENQ | KPIYKSDKCT | EADTCKNSPL | DELEEGEIRS | DSETSKPQES | 
    1000:
    FEKNSKRRVS | ADVRKSKTIP | RRGKSTVCLD | KDSRKTHVRI | HQTNNKWNKR | 
    1050:
    PDKSSRSSKT | EKKDKVMSTS | SLEKIVPIIA | VPSSEQEIMH | MLRMIRKHVR | 
    1100:
    KNYMKFKAKF | SLIQFHRIIE | SAILSFTSLI | KHLNLHKISK | SVTTLQKNLC | 
    1150:
    DIIESKLKQV | KKNGIVDRLF | EQQLPDMKKK | LWKFVDDQLD | YLFAKLKKIL | 
    1200:
    VCDSKSFGRD | SDEGKLEKTS | KQNAQYSNSQ | KRSVDNSNRE | LLKEKLSKSE | 
    1250:
    DPVHYKSLVG | CKKSEENYQD | QNNSSINTVK | HDIKKNFNIC | FDNIKNSQSE | 
    1300:
    ERSLEVHCPS | TPKSEKNEGS | SIEDAQTSQH | ATLKPERSFE | ILTEQQASSL | 
    1350:
    TFNLVSDAQM | GEIFKSLLQG | SDLLDSSVNC | TEKSEWELKT | PEKQLLETLK | 
    1400:
    CESIPACTTE | ELVSGVASPC | PKMISDDNWS | LLSSEKGPSL | SSGLSLPVHP | 
    1450:
    DVLDESCMFE | VSTNLPLSKD | NVCSVEKSKP | CVSSILLEDL | AVSLTVPSPL | 
    1500:
    KSDGHLSFLK | PDMSSSSTPE | EVISAHFSED | ALLEEEDASE | QDIHLALESD | 
    1550:
    NSSSKSSCSS | SWTSRSVAPG | FQYHPNLPMH | AVIMEKSNDH | FIVKIRRATP | 
    1600:
    STSSGLKQSM | MPDELLTSLP | RHGKEADEGP | EKEYISCQNT | VFKSVEELEN | 
    1650:
    SNKNVDGSKS | THEEQSSMIQ | TQVPDIYEFL | KDASDKMGHS | DEVADECFKL | 
    1700:
    HQVWETKVPE | SIEELPSMEE | ISHSVGEHLP | NTYVDLTKDP | VTETKNLGEF | 
    1750:
    IEVTVLHIDQ | LGCSGGNLNQ | SAQILDNSLQ | ADTVGAFIDL | TQDASSEAKS | 
    1800:
    EGNHPALAVE | DLGCGVIQVD | EDNCKEEKAQ | VANRPLKCIV | EETYIDLTTE | 
    1850:
    SPSSCEVKKD | ELKSEPGSNC | DNSELPGTLH | NSHKKRRNIS | DLNHPHKKQR | 
    1900:
    KETDLTNKEK | TKKPTQDSCE | NTEAHQKKAS | KKKAPPVTKD | PSSLKATPGI | 
    1950:
    KDSSAALATS | TSLSAKNVIK | KKGEIIILWT | RNDDREILLE | CQKRGPSFKT | 
    1982:
    FAYLAAKLDK | NPNQVSERFQ | QLMKLFEKSK | CR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human CASP8-associated protein 2
    ELISA Kit for Human CASP8-associated protein 2
    CLIA Kit for Human CASP8-associated protein 2
    CLIA Kit for Human CASP8-associated protein 2
    Polyclonal Antibody for Human CASP8-associated protein 2
    Polyclonal Antibody for Human CASP8-associated protein 2
    Monoclonal Antibody for Human CASP8-associated protein 2
    Monoclonal Antibody for Human CASP8-associated protein 2
    Protein for Human CASP8-associated protein 2
    Protein for Human CASP8-associated protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Reply: searching for FLASH domains."
      Kimura T. , Imai Y. , Yonehara S.
      Nature401:662-663(1999)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: T-cell.
    2. 2.
      "RIP25, a human homolog of Mus musculus FLASH, is involved in IL-2 signaling."
      Yan M.D. , Sun L.Y. , Liu X.Y. , Zheng Z.C.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Peripheral blood leukocyte.
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
      tissue: Testis.
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1478-1982
      tissue: Placenta.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 714-1982
    10. 10.
      "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators."
      Kino T. , Chrousos G.P.
      J. Biol. Chem.278:3023-3029(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCOA2;SUBCELLULAR LOCATION;INDUCTION
    11. 11.
      "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors."
      Kino T. , Ichijo T. , Chrousos G.P.
      J. Steroid Biochem. Mol. Biol.92:357-363(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCOA3
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NPAT;SUBCELLULAR LOCATION
    13. 13.
      "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."
      Milovic-Holm K. , Krieghoff E. , Jensen K. , Will H. , Hofmann T.G.
      EMBO J.26:391-401(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN FAS-MEDIATED APOPTOSIS;INTERACTION WITH CASP8 AND SP100;SUBCELLULAR LOCATION
    14. 14.
      "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J. , Vasilescu J. , Lambert J.-P. , Smith J.C. , Figeys D.
      Proteomics7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-92 AND LYS-93
      tissue: Mammary cancer.
    15. 15.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    16. 16.
      "Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase."
      Kiriyama M. , Kobayashi Y. , Saito M. , Ishikawa F. , Yonehara S.
      Mol. Cell. Biol.29:4729-4741(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRRT
    17. 17.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      "PolySUMO-binding proteins identified through a string search."
      Sun H. , Hunter T.
      J. Biol. Chem.287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF REPEAT SUMO-INTERACTING MOTIF;INTERACTION WITH SUMO1 AND SUMO2
    20. 20.
      "Solution NMR structure of CASP8-associated protein 2 from Homo sapiens, Northeast structural genomics consortium (NESG) target HR8150A."
      Northeast structural genomics consortium (NESG)
      Submitted (2012-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1916-1982
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