Gene name:
CASP8AP2(FLASH;KIAA1315;RIP25);
Protein name:
CASP8-associated protein 2;
Alternative:
FLICE-associated huge protein;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2, NCOA3, SRRT/ARS2 and TRAF2. Interacts with NPAT.
Function:
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Subcellular Location:
Cytoplasm
Nucleus
Localizes to discrete nuclear foci.
Protein Attributes:
50:
MAADDDNGDG | TSLFDVFSAS | PLKNNDEGSL | DIYAGLDSAV | SDSASKSCVP |
100:
SRNCLDLYEE | ILTEEGTAKE | ATYNDLQVEY | GKCQLQMKEL | MKKFKEIQTQ |
150:
NFSLINENQS | LKKNISALIK | TARVEINRKD | EEISNLHQRL | SEFPHFRNNH |
200:
KTARTFDTVK | TKDLKSRSPH | LDDCSKTDHR | AKSDVSKDVH | HSTSLPNLEK |
250:
EGKPHSDKRS | TSHLPTSVEK | HCTNGVWSRS | HYQVGEGSSN | EDSRRGRKDI |
300:
RHSQFNRGTE | RVRKDLSTGC | GDGEPRILEA | SQRLQGHPEK | YGKGEPKTES |
350:
KSSKFKSNSD | SDYKGERINS | SWEKETPGER | SHSRVDSQSD | KKLERQSERS |
400:
QNINRKEVKS | QDKEERKVDQ | KPKSVVKDQD | HWRRSERASL | PHSKNEITFS |
450:
HNSSKYHLEE | RRGWEDCKRD | KSVNSHSFQD | GRCPSSLSNS | RTHKNIDSKE |
500:
VDAMHQWENT | PLKAERHRTE | DKRKREQESK | EENRHIRNEK | RVPTEHLQKT |
550:
NKETKKTTTD | LKKQNEPKTD | KGEVLDNGVS | EGADNKELAM | KAESGPNETK |
600:
NKDLKLSFMK | KLNLTLSPAK | KQPVSQDNQH | KITDIPKSSG | VCDSESSMQV |
650:
KTVAYVPSIS | EHILGEAAVS | EHTMGETKST | LLEPKVALLA | VTEPRIGISE |
700:
TNKEDENSLL | VRSVDNTMHC | EEPICGTETS | FPSPMEIQQT | ESLFPSTGMK |
750:
QTINNGRAAA | PVVMDVLQTD | VSQNFGLELD | TKRNDNSDYC | GISEGMEMKV |
800:
ALSTTVSETT | ESILQPSIEE | ADILPIMLSE | DNNPKFEPSV | IVTPLVESKS |
850:
CHLEPCLPKE | TLDSSLQQTE | LMDHRMATGE | TNSVYHDDDN | SVLSIDLNHL |
900:
RPIPEAISPL | NSPVRPVAKV | LRNESPPQVP | VYNNSHKDVF | LPNSAHSTSK |
950:
SQSDLNKENQ | KPIYKSDKCT | EADTCKNSPL | DELEEGEIRS | DSETSKPQES |
1000:
FEKNSKRRVS | ADVRKSKTIP | RRGKSTVCLD | KDSRKTHVRI | HQTNNKWNKR |
1050:
PDKSSRSSKT | EKKDKVMSTS | SLEKIVPIIA | VPSSEQEIMH | MLRMIRKHVR |
1100:
KNYMKFKAKF | SLIQFHRIIE | SAILSFTSLI | KHLNLHKISK | SVTTLQKNLC |
1150:
DIIESKLKQV | KKNGIVDRLF | EQQLPDMKKK | LWKFVDDQLD | YLFAKLKKIL |
1200:
VCDSKSFGRD | SDEGKLEKTS | KQNAQYSNSQ | KRSVDNSNRE | LLKEKLSKSE |
1250:
DPVHYKSLVG | CKKSEENYQD | QNNSSINTVK | HDIKKNFNIC | FDNIKNSQSE |
1300:
ERSLEVHCPS | TPKSEKNEGS | SIEDAQTSQH | ATLKPERSFE | ILTEQQASSL |
1350:
TFNLVSDAQM | GEIFKSLLQG | SDLLDSSVNC | TEKSEWELKT | PEKQLLETLK |
1400:
CESIPACTTE | ELVSGVASPC | PKMISDDNWS | LLSSEKGPSL | SSGLSLPVHP |
1450:
DVLDESCMFE | VSTNLPLSKD | NVCSVEKSKP | CVSSILLEDL | AVSLTVPSPL |
1500:
KSDGHLSFLK | PDMSSSSTPE | EVISAHFSED | ALLEEEDASE | QDIHLALESD |
1550:
NSSSKSSCSS | SWTSRSVAPG | FQYHPNLPMH | AVIMEKSNDH | FIVKIRRATP |
1600:
STSSGLKQSM | MPDELLTSLP | RHGKEADEGP | EKEYISCQNT | VFKSVEELEN |
1650:
SNKNVDGSKS | THEEQSSMIQ | TQVPDIYEFL | KDASDKMGHS | DEVADECFKL |
1700:
HQVWETKVPE | SIEELPSMEE | ISHSVGEHLP | NTYVDLTKDP | VTETKNLGEF |
1750:
IEVTVLHIDQ | LGCSGGNLNQ | SAQILDNSLQ | ADTVGAFIDL | TQDASSEAKS |
1800:
EGNHPALAVE | DLGCGVIQVD | EDNCKEEKAQ | VANRPLKCIV | EETYIDLTTE |
1850:
SPSSCEVKKD | ELKSEPGSNC | DNSELPGTLH | NSHKKRRNIS | DLNHPHKKQR |
1900:
KETDLTNKEK | TKKPTQDSCE | NTEAHQKKAS | KKKAPPVTKD | PSSLKATPGI |
1950:
KDSSAALATS | TSLSAKNVIK | KKGEIIILWT | RNDDREILLE | CQKRGPSFKT |
1982:
FAYLAAKLDK | NPNQVSERFQ | QLMKLFEKSK | CR

Vaild Sequence:
Related Databases
Uniprot: