Cabp1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCabp1 ELISA Kit for Rat(Rattus norvegicus)

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Cabp1 (Gene name),

Calcium-binding protein 1 (Protein name ), CABP1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cabp1;

Protein name:

Calcium-binding protein 1(CaBP1);

Alternative:

Caldendrin;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts ITPR1, ITPR2 and ITPR3. The strength of this interaction inversely correlates with calcium concentration. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts with CACNA1C. Interacts with CACNA1D (By similarity). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B. Interacts (via EF-hands 1 and 2) with NELF in a calcium dependent manner after synaptic NMDA receptor stimulation. This binding prevents nuclear import of NELF. Interacts with MYO1C and TRPC5.

Function:

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (By similarity). Prevents NMDA receptor-induced cellular degeneration.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton Occurs in both the cytoplasmic and cytoskeletal compartment of cell somata and dendrites.

Protein Attributes:

Sequence length:

298

Sequence:

50:

100:

150:

200:

250:

298:

STSELREAMR | KLLGHQVGHR | DIEEIIRDVD | LNGDGRVDFE | EFVRMMSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:171051

Pfam:

PF00036

UniGene:

Rn.23560

String:

O88751

Uniprot:

O88751

FOR

ELISA Kit for Rat CaBP1

CLIA Kit for Rat CaBP1

Polyclonal Antibody for Rat CaBP1

Monoclonal Antibody for Rat CaBP1

Protein for Rat CaBP1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment."
Seidenbecher C.I. , Langnaese K. , Sanmarti-Vila L. , Boeckers T.M. , Smalla K.-H. , Sabel B.A. , Garner C.C. , Gundelfinger E.D. , Kreutz M.R.
J. Biol. Chem.273:21324-21331(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PHOSPHORYLATION
strain: Sprague-Dawley.
2.

"The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system."
Laube G. , Seidenbecher C.I. , Richter K. , Dieterich D.C. , Hoffmann B. , Landwehr M. , Smalla K.H. , Winter C. , Boeckers T.M. , Wolf G. , Gundelfinger E.D. , Kreutz M.R.
Mol. Cell. Neurosci.19:459-475(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);TISSUE SPECIFICITY
tissue: Brain.
3.

Seidenbecher C.I.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 290-291
4.

"Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
Yang J. , McBride S. , Mak D.-O.D. , Vardi N. , Palczewski K. , Haeseleer F. , Foskett J.K.
Proc. Natl. Acad. Sci. U.S.A.99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITPR1; ITPR2 AND ITPR3
5.

"Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1."
Lee A. , Westenbroek R.E. , Haeseleer F. , Palczewski K. , Scheuer T. , Catterall W.A.
Nat. Neurosci.5:210-217(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CACNA1A
6.

"Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
Seidenbecher C.I. , Landwehr M. , Smalla K.H. , Kreutz M. , Dieterich D.C. , Zuschratter W. , Reissner C. , Hammarback J.A. , Bockers T.M. , Gundelfinger E.D. , Kreutz M.R.
J. Mol. Biol.336:957-970(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP1LC3B;SUBCELLULAR LOCATION
7.

"Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus."
Dieterich D.C. , Karpova A. , Mikhaylova M. , Zdobnova I. , Konig I. , Landwehr M. , Kreutz M. , Smalla K.H. , Richter K. , Landgraf P. , Reissner C. , Boeckers T.M. , Zuschratter W. , Spilker C. , Seidenbecher C.I. , Garner C.C. , Gundelfinger E.D. , Kreutz M.R.
PLoS Biol.6:E34-E34(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NSMF

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