Cacna1c ELISA Kit for Mouse(Mus musculus) | EIAab.comCacna1c ELISA Kit for Mouse(Mus musculus)

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Cacna1c (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1C (Protein name ), CAC1C_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1c(Cach2;Cacn2;Cacnl1a1;Cchl1a1);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1C;

Alternative:

MELC-CC;Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;Voltage-gated calcium channel subunit alpha Cav1.2;Mouse brain class C(MBC);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner. Interacts with CABP1 and CACNA2D4.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Protein Attributes:

Sequence length:

2139

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2139:

RDPGQDRAVA | PEDESCAYAL | GRGRSEEALA | DSRSYVSNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

UniGene:

Mm.436656

SMR:

Q01815

String:

Q01815

KEGG:

mmu:12288

Uniprot:

Q01815

FOR

ELISA Kit for Mouse Voltage-dependent L-type calcium channel subunit alpha-1C

CLIA Kit for Mouse Voltage-dependent L-type calcium channel subunit alpha-1C

Polyclonal Antibody for Mouse Voltage-dependent L-type calcium channel subunit alpha-1C

Monoclonal Antibody for Mouse Voltage-dependent L-type calcium channel subunit alpha-1C

Protein for Mouse Voltage-dependent L-type calcium channel subunit alpha-1C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of a cDNA for a neuronal calcium channel alpha1 subunit enhances secretion from adrenal chromaffin cells."
Ma W.-J. , Holz R.W. , Uhler M.D.
J. Biol. Chem.267:22728-22732(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Brain.
2.

"Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
Perez-Reyes E. , Wei X. , Castellano A. , Birnbaumer L.
J. Biol. Chem.265:20430-20436(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1162-1455 (ISOFORMS 1 AND 2)
strain: ICR.
tissue: Ovary.
3.

Chaudhari N.
Submitted (1993-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 762-1070
4.

"Cloning and expression of a novel truncated calcium channel from non-excitable cells."
Ma Y. , Kobrinsky E. , Marks A.R.
J. Biol. Chem.270:483-493(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-2139 (ISOFORM 3)
strain: DBA/2J.
tissue: Erythroleukemia.
5.

"Characterization of Ca2+-binding protein 5 knockout mouse retina."
Rieke F. , Lee A. , Haeseleer F.
Invest. Ophthalmol. Vis. Sci.49:5126-5135(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CABP5;TISSUE SPECIFICITY
6.

"CIB1 is a regulator of pathological cardiac hypertrophy."
Heineke J. , Auger-Messier M. , Correll R.N. , Xu J. , Benard M.J. , Yuan W. , Drexler H. , Parise L.V. , Molkentin J.D.
Nat. Med.16:872-879(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CIB1

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