CACNA1C ELISA Kit for Rabbit(Oryctolagus cuniculus) | EIAab.comCACNA1C ELISA Kit for Rabbit(Oryctolagus cuniculus)

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Index > Protein center > CACNA1C(Gene name) > Rabbit

CACNA1C (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1C (Protein name ), CAC1C_RABIT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CACNA1C(CACH2;CACN2;CACNL1A1;CCHL1A1);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1C;

Alternative:

Smooth muscle calcium channel blocker receptor(CACB-receptor);Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;Voltage-gated calcium channel subunit alpha Cav1.2;

Organism:

Rabbit (Oryctolagus cuniculus).

General Annotation

Sub Unit:

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CACNA2D4 (By similarity). Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Protein Attributes:

Sequence length:

2171

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2171:

APGCGQSEEA | LADRRAGVSS | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Ocu.1835

Pfam:

PF08763

SMR:

P15381

Uniprot:

P15381

FOR

ELISA Kit for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C

CLIA Kit for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C

Polyclonal Antibody for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C

Monoclonal Antibody for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C

Protein for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel."
Mikami A. , Imoto K. , Tanabe T. , Ni Idomme T. , Mori Y. , Takeshima H. , Narumiya S. , Numa S.
Nature340:230-233(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Heart.
2.

"Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung."
Biel M. , Ruth P. , Bosse E. , Hullin R. , Stuehmer W. , Flockerzi V. , Hoffmann F.
FEBS Lett.269:409-412(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Heart.
tissue: Lung.
3.

"Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels."
Biel M. , Hullin R. , Freundner S. , Singer D. , Dascal N. , Flockerzi V. , Hofmann F.
Eur. J. Biochem.200:81-88(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-98 (ISOFORM 5)
tissue: Heart muscle.
4.

"Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
Perez-Reyes E. , Wei X. , Castellano A. , Birnbaumer L.
J. Biol. Chem.265:20430-20436(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1192-1485 (ISOFORM 2)
tissue: Heart.
5.

"Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels."
Yang J. , Ellinor P.T. , Sather W.A. , Zhang J.-F. , Tsien R.W.
Nature366:158-161(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;CALCIUM-BINDING
6.

"A mutation affecting dihydropyridine-sensitive current levels and activation kinetics in Drosophila muscle and mammalian heart calcium channels."
Ren D. , Xu H. , Eberl D.F. , Chopra M. , Hall L.M.
J. Neurosci.18:2335-2341(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-168
7.

"Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel."
Yoshida A. , Takahashi M. , Nishimura S. , Takeshima H. , Kokubun S.
FEBS Lett.309:343-349(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKA
8.

"Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit."
Pragnell M. , de Waard M. , Mori Y. , Tanabe T. , Snutch T.P. , Campbell K.P.
Nature368:67-70(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BETA-SUBUNIT BINDING DOMAIN
9.

"Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels."
de Leon M. , Wang Y. , Jones L. , Perez-Reyes E. , Wei X. , Soong T.W. , Snutch T.P. , Yue D.T.
Science270:1502-1505(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EF-HAND MOTIF AND CALCIUM INACTIVATION
10.

"Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart."
Yada H. , Murata M. , Shimoda K. , Yuasa S. , Kawaguchi H. , Ieda M. , Adachi T. , Murata M. , Ogawa S. , Fukuda K.
Circ. Res.101:69-77(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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