Cacna1c ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCacna1c ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Cacna1c(Gene name) > Rat

Cacna1c (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1C (Protein name ), CAC1C_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1c(Cach2;Cacn2;Cacnl1a1;Cchl1a1);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1C;

Alternative:

Rat brain class C(RBC);Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;Voltage-gated calcium channel subunit alpha Cav1.2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via C-terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with CACNA2D4 (By similarity). Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Protein Attributes:

Sequence length:

2169

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2169:

GRGRSEEALP | DSRSYVSNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

KEGG:

rno:24239

SMR:

P22002

String:

P22002

UniGene:

Rn.9827

Uniprot:

P22002

FOR

ELISA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1C

CLIA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1C

Polyclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1C

Monoclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1C

Protein for Rat Voltage-dependent L-type calcium channel subunit alpha-1C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms."
Koch W.J. , Ellinor P.T. , Schwartz A.
J. Biol. Chem.265:17786-17791(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Aorta.
2.

"Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS."
Snutch T.P. , Tomlinson W.J. , Leonard J.P. , Gilbert M.M.
Neuron7:45-57(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5)
tissue: Brain.
3.

"Rat brain expresses a heterogeneous family of calcium channels."
Snutch T.P. , Leonard J.P. , Gilbert M.M. , Lester H.A. , Davidson N.
Proc. Natl. Acad. Sci. U.S.A.87:3391-3395(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1168-1413 (ISOFORM 1)
4.

"Mutually exclusive exon splicing of the cardiac calcium channel a1 subunit generates developmentally regulated isoforms in the rat heart."
Diebold R.J. , Koch W.J. , Ellinor P.T. , Wang J.-J. , Muthuchamy M. , Wieczorek D.F. , Schwartz A.
Proc. Natl. Acad. Sci. U.S.A.89:1497-1501(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1269-1415 (ISOFORMS 1; 2 AND 3)
5.

"Changes in transcripts encoding calcium channel subunits of rat myometrium during pregnancy."
Tezuka N. , Ali M. , Chwalisz K. , Garfield R.E.
Am. J. Physiol.269:C1008-C1017(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1269-1387
tissue: Myometrium.
6.

"Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
Barry E.L.R. , Gesek F.A. , Froehner S.C. , Friedman P.A.
Proc. Natl. Acad. Sci. U.S.A.92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1202-1495 (ISOFORM 3)
tissue: Osteosarcoma.
7.

"Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit."
Hell J.W. , Yokoyama C.T. , Wong S.T. , Warner C. , Snutch T.P. , Catterall W.A.
J. Biol. Chem.268:19451-19457(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
8.

"Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels."
Zhou H. , Kim S.-A. , Kirk E.A. , Tippens A.L. , Sun H. , Haeseleer F. , Lee A.
J. Neurosci.24:4698-4708(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CABP1
9.

"Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels."
Chen Y.H. , Li M.H. , Zhang Y. , He L.L. , Yamada Y. , Fitzmaurice A. , Shen Y. , Zhang H. , Tong L. , Yang J.
Nature429:675-680(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 452-476

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