Cacna1d ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCacna1d ELISA Kit for Rat(Rattus norvegicus)

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Cacna1d (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1D (Protein name ), CAC1D_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1d(Cach3;Cacn4;Cacnl1a2;Cchl1a2);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1D;

Alternative:

Rat brain class D(RBD);Calcium channel, L type, alpha-1 polypeptide, isoform 2;Voltage-gated calcium channel subunit alpha Cav1.3;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2203

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TTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

KEGG:

rno:29716

UniGene:

Rn.89671

SMR:

P27732

String:

P27732

Uniprot:

P27732

FOR

ELISA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1D

CLIA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1D

Polyclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1D

Monoclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1D

Protein for Rat Voltage-dependent L-type calcium channel subunit alpha-1D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells."
Ihara Y. , Yamada Y. , Fujii Y. , Gonoi T. , Yano H. , Yasuda K. , Inagaki N. , Seino Y. , Seino S.
Mol. Endocrinol.9:121-130(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Insulinoma.
2.

"Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel."
Hui A. , Ellinor P.T. , Krizanova O. , Wang J.-J. , Diebold R.J. , Schwartz A.
Neuron7:35-44(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 13)
tissue: Brain.
3.

"Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene."
Kamp T.J. , Mitas M. , Fields K.L. , Asoh S. , Chin H. , Marban E. , Nirenberg M.
Cell. Mol. Neurobiol.15:307-326(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125
4.

"Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney."
Yu A.S.L. , Hebert S.C. , Brenner B.M. , Lytton J.
Proc. Natl. Acad. Sci. U.S.A.89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1100-1410 (ISOFORMS 4 AND 11)
tissue: Kidney.
5.

"Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
Barry E.L.R. , Gesek F.A. , Froehner S.C. , Friedman P.A.
Proc. Natl. Acad. Sci. U.S.A.92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1218-1498 (ISOFORM 12)
tissue: Osteosarcoma.
6.

"Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region."
Brereton H.M. , Harland M.L. , Froscio M. , Petronijevic T. , Barritt G.J.
Cell Calcium22:39-52(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1200-1493 (ISOFORMS 3; 4; 5; 9 AND 10)
tissue: Hepatoma.
7.

"Rat brain expresses a heterogeneous family of calcium channels."
Snutch T.P. , Leonard J.P. , Gilbert M.M. , Lester H.A. , Davidson N.
Proc. Natl. Acad. Sci. U.S.A.87:3391-3395(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1307-1479 (ISOFORM 3)
8.

"Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells."
Yang P.S. , Alseikhan B.A. , Hiel H. , Grant L. , Mori M.X. , Yang W. , Fuchs P.A. , Yue D.T.
J. Neurosci.26:10677-10689(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 1656-ILE-GLN-1657;INTERACTION WITH CABP1 AND CABP4;TISSUE SPECIFICITY

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