Cacna1e ELISA Kit for Mouse(Mus musculus) | EIAab.comCacna1e ELISA Kit for Mouse(Mus musculus)

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Cacna1e (Gene name),

Voltage-dependent R-type calcium channel subunit alpha-1E (Protein name ), CAC1E_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1e(Cach6;Cacnl1a6;Cchra1);

Protein name:

Voltage-dependent R-type calcium channel subunit alpha-1E;

Alternative:

Calcium channel, L type, alpha-1 polypeptide, isoform 6;Brain calcium channel II(BII);Voltage-gated calcium channel subunit alpha Cav2.3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2272

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2272:

WAGMMCGAVS | DLLSDTEEDD | KC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

String:

Q61290

UniGene:

Mm.267517

SMR:

Q61290

Uniprot:

Q61290

FOR

ELISA Kit for Mouse Voltage-dependent R-type calcium channel subunit alpha-1E

CLIA Kit for Mouse Voltage-dependent R-type calcium channel subunit alpha-1E

Polyclonal Antibody for Mouse Voltage-dependent R-type calcium channel subunit alpha-1E

Monoclonal Antibody for Mouse Voltage-dependent R-type calcium channel subunit alpha-1E

Protein for Mouse Voltage-dependent R-type calcium channel subunit alpha-1E

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure and functional characterization of neuronal alpha 1E calcium channel subtypes."
Williams M.E. , Marubio L.M. , Deal C.R. , Hans M. , Brust P.F. , Philipson L.H. , Miller R.J. , Johnson E.C. , Harpold M.M. , Ellis S.B.
J. Biol. Chem.269:22347-22357(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Brain.
2.

"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain cortex.

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