Protein name:
Voltage-dependent T-type calcium channel subunit alpha-1G ;
Alternative:
Voltage-gated calcium channel subunit alpha Cav3.1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDEEEDGAGA | EESGQPRSFT | QLNDLSGAGG | RQGPGSTEKD | PGSADSEAEG |
100:
LPYPALAPVV | FFYLSQDSRP | RSWCLRTVCN | PWFERVSMLV | ILLNCVTLGM |
150:
FRPCEDIACD | SQRCRILQAF | DDFIFAFFAV | EMVVKMVALG | IFGKKCYLGD |
200:
TWNRLDFFIV | IAGMLEYSLD | LQNVSFSAVR | TVRVLRPLRA | INRVPSMRIL |
250:
VTLLLDTLPM | LGNVLLLCFF | VFFIFGIVGV | QLWAGLLRNR | CFLPENFSLP |
300:
LSVDLEPYYQ | TENEDESPFI | CSQPRENGMR | SCRSVPTLRG | EGGGGPPCSL |
350:
DYETYNSSSN | TTCVNWNQYY | TNCSAGEHNP | FKGAINFDNI | GYAWIAIFQV |
400:
ITLEGWVDIM | YFVMDAHSFY | NFIYFILLII | VGSFFMINLC | LVVIATQFSE |
450:
TKQRESQLMR | EQRVRFLSNA | STLASFSEPG | SCYEELLKYL | VYILRKAARR |
500:
LAQVSRAIGV | RAGLLSSPVA | RSGQEPQPSG | SCTRSHRRLS | VHHLVHHHHH |
550:
HHHHYHLGNG | TLRVPRASPE | IQDRDANGSR | RLMLPPPSTP | TPSGGPPRGA |
600:
ESVHSFYHAD | CHLEPVRCQA | PPPRCPSEAS | GRTVGSGKVY | PTVHTSPPPE |
650:
ILKDKALVEV | APSPGPPTLT | SFNIPPGPFS | SMHKLLETQS | TGACHSSCKI |
700:
SSPCSKADSG | ACGPDSCPYC | ARTGAGEPES | ADHVMPDSDS | EAVYEFTQDA |
750:
QHSDLRDPHS | RRRQRSLGPD | AEPSSVLAFW | RLICDTFRKI | VDSKYFGRGI |
800:
MIAILVNTLS | MGIEYHEQPE | ELTNALEISN | IVFTSLFALE | MLLKLLVYGP |
850:
FGYIKNPYNI | FDGVIVVISV | WEIVGQQGGG | LSVLRTFRLM | RVLKLVRFLP |
900:
ALQRQLVVLM | KTMDNVATFC | MLLMLFIFIF | SILGMHLFGC | KFASERDGDT |
950:
LPDRKNFDSL | LWAIVTVFQI | LTQEDWNKVL | YNGMASTSSW | AALYFIALMT |
1000:
FGNYVLFNLL | VAILVEGFQA | EGDATKSESE | PDFFSPSVDG | DGDRKKRLAL |
1050:
VALGEHAELR | KSLLPPLIIH | TAATPMSHPK | SSSTGVGEAL | GSGSRRTSSS |
1100:
GSAEPGAAHH | EMKCPPSARS | SPHSPWSAAS | SWTSRRSSRN | SLGRAPSLKR |
1150:
RSPSGERRSL | LSGEGQESQD | EEESSEEDRA | SPAGSDHRHR | GSLEREAKSS |
1200:
FDLPDTLQVP | GLHRTASGRS | SASEHQDCNG | KSASGRLART | LRTDDPQLDG |
1250:
DDDNDEGNLS | KGERIQAWVR | SRLPACCRER | DSWSAYIFPP | QSRFRLLCHR |
1300:
IITHKMFDHV | VLVIIFLNCI | TIAMERPKID | PHSAERIFLT | LSNYIFTAVF |
1350:
LAEMTVKVVA | LGWCFGEQAY | LRSSWNVLDG | LLVLISVIDI | LVSMVSDSGT |
1400:
KILGMLRVLR | LLRTLRPLRV | ISRAQGLKLV | VETLMSSLKP | IGNIVVICCA |
1450:
FFIIFGILGV | QLFKGKFFVC | QGEDTRNITN | KSDCAEASYR | WVRHKYNFDN |
1500:
LGQALMSLFV | LASKDGWVDI | MYDGLDAVGV | DQQPIMNHNP | WMLLYFISFL |
1550:
LIVAFFVLNM | FVGVVVENFH | KCRQHQEEEE | ARRREEKRLR | RLEKKRRSKE |
1600:
KQMAEAQCKP | YYSDYSRFRL | LVHHLCTSHY | LDLFITGVIG | LNVVTMAMEH |
1650:
YQQPQILDEA | LKICNYIFTV | IFVFESVFKL | VAFGFRRFFQ | DRWNQLDLAI |
1700:
VLLSIMGITL | EEIEVNLSLP | INPTIIRIMR | VLRIARVLKL | LKMAVGMRAL |
1750:
LHTVMQALPQ | VGNLGLLFML | LFFIFAALGV | ELFGDLECDE | THPCEGLGRH |
1800:
ATFRNFGMAF | LTLFRVSTGD | NWNGIMKDTL | RDCDQESTCY | NTVISPIYFV |
1850:
SFVLTAQFVL | VNVVIAVLMK | HLEESNKEAK | EEAELEAELE | LEMKTLSPQP |
1900:
HSPLGSPFLW | PGVEGVNSTD | SPKPGAPHTT | AHIGAASGFS | LEHPTMVPHP |
1950:
EEVPVPLGPD | LLTVRKSGVS | RTHSLPNDSY | MCRNGSTAER | SLGHRGWGLP |
2000:
KAQSGSILSV | HSQPADTSCI | LQLPKDVHYL | LQPHGAPTWG | AIPKLPPPGR |
2050:
SPLAQRPLRR | QAAIRTDSLD | VQGLGSREDL | LSEVSGPSCP | LTRSSSFWGG |
2100:
SSIQVQQRSG | IQSKVSKHIR | LPAPCPGLEP | SWAKDPPETR | SSLELDTELS |
2150:
WISGDLLPSS | QEEPLFPRDL | KKCYSVETQS | CRRRPGFWLD | EQRRHSIAVS |
2200:
CLDSGSQPRL | CPSPSSLGGQ | PLGGPGSRPK | KKLSPPSISI | DPPESQGSRP |
2250:
PCSPGVCLRR | RAPASDSKDP | SVSSPLDSTA | ASPSPKKDTL | SLSGLSSDPT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
ELISA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
ELISA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
CLIA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
CLIA Kit for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Polyclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Polyclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Monoclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Monoclonal Antibody for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Protein for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
Protein for Rat Voltage-dependent T-type calcium channel subunit alpha-1G
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .